Results 191 to 200 of about 1,265,065 (269)

From Nucleobases to Bioactive NHC‐Based Gold and Silver Complexes With Anticancer and Antiviral Activity

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Herein, we reported the design and synthesis of a novel series of N‐heterocyclic carbene (NHC) complexes originated from the imidazole ring of guanine and guanosine and with different counterions (iodide, acetate, and aminoacidate). The evaluation of the biological activities, that is anticancer and antiviral, indicated L2AuOAc as the best complex ...
Domenico Iacopetta, Jessica Ceramella, Paola Checconi, Flavio Frezza, Maria Marra, Annaluisa Mariconda, Assunta D’Amato, Alessia Catalano, Stefano Aquaro, Pasquale Longo, Maria Stefania Sinicropi   +10 more
wiley   +1 more source

Differential roles of type I topoisomerases in regulating HPV pathogenesis. [PDF]

Proc Natl Acad Sci U S A
Vats A, Templeton CW, Laimins L.
europepmc   +1 more source

Synthesis and dissolution of hemicatenanes by type IA DNA topoisomerases. [PDF]

Proc Natl Acad Sci U S A, 2013
Lee SH, Siaw GE, Willcox S, Griffith JD, Hsieh TS.   +4 more
europepmc   +1 more source

Actinomycin Derivatives: Structural Diversification and Biological Activities

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Actinomycins are chromopeptide antibiotics exhibiting remarkable structural diversity and broad bioactivity. This review traces their development from naturally occurring D‐, X‐, A‐, G‐, Y‐, and Z‐type analogs to precursor‐directed, synthetic, and semisynthetic derivatives.
Özge Can, Erdal Bedir
wiley   +1 more source

1‐(Acetylamino)thioxanthones and Derivatives: Synthesis From 1‐Halogenothioxanthones and Biological Properties

European Journal of Organic Chemistry, Volume 29, Issue 30, 12 August 2026.
The conversion of 1‐halogenothioxanthones into 1‐(acetylamino) derivatives and their NaH‐mediated cyclization have been optimized. This rapid method yields thiochromeno[4,3,2‐de]quinol‐2‐ones that exhibit promising in vitro anticancer activity. Institute and/or researcher Bluesky usernames: https://bsky.app/profile/iscr‐rennes.bsky.social.
Najet Ballagha, Frédéric Lassagne, William Erb, Isabelle Rouaud, Sophie Tomasi, Ziad Fajloun, Mona El Samarji, Mohamad Rima, Anamaria Mendonça Santos, Laurent Picot, Valérie Thiéry, Hédi M’Rabet, Florence Mongin   +12 more
wiley   +1 more source

TORCphysics: a physical model of DNA-topology-controlled gene expression. [PDF]

Nucleic Acids Res
Velasco-Berrelleza V, Rainford PF, Mogre A, Benham CJ, Dorman CJ, Kröger C, Stepney S, Harris SA.   +7 more
europepmc   +1 more source

Mechanistic basis for relaxation of DNA supercoils by human topoisomerase IIIα-RMI1-RMI2. [PDF]

Proc Natl Acad Sci U S A
Spakman D, Biebricher AS, Bizard AH, Hickson ID, Peterman EJG, Wuite GJL, King GA.   +6 more
europepmc   +1 more source

Topoisomerases regulate alternative transcription start site selection in yeast. [PDF]

G3 (Bethesda)
Elgood Hunt E, Vivori C, Albihlal WS, van Werven FJ.   +3 more
europepmc   +1 more source

Chromosome segregation in a minimal bacterial cell driven by SMC protein complexes. [PDF]

Protein Sci
Maytin AK, Gilbert BR, Luthey-Schulten Z.   +2 more
europepmc   +1 more source