Bacterial type II topoisomerases cleave DNA in a species-specific manner. [PDF]
Nucleic Acids ResMorgan IL +4 more
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Topoisomerase inhibitors in cervical cancer: mechanistic insights and therapeutic strategies. [PDF]
Mol MedReddy Y +6 more
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Direct trapping of the transport-segment DNA by the central domain of type IIA topoisomerases. [PDF]
Sci AdvXin Y +6 more
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Identification of a <i>TOP3A</i> genetic variant as a novel biomarker for sensitivity to doxorubicin. [PDF]
Front PharmacolTakacova T, Schirmer MA.
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Gyrase and Topoisomerase IV as Antibacterial Targets for Gepotidacin and Zoliflodacin: Teaching Old Enzymes New Tricks. [PDF]
Int J Mol SciOsheroff N.
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Processing of DNA Topoisomerase II-DNA-Protein Crosslinks Associated With Anticancer Drugs. [PDF]
Genes CellsSakasai R, Iwabuchi K.
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Molecular Determinants of Response and Rational Drug Combinations for Antibody-Drug Conjugates (ADCs) with Topoisomerase I (TOP1) Inhibitor Payloads. [PDF]
J Mol BiolPommier Y.
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DNA topological regulation in RNA polymerase II transcription. [PDF]
Cell Mol Biol LettBunch H.
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DNA topoisomerases are enzymes that control the topological state of DNA in all cells; they have central roles in DNA replication and transcription. They are classified into two types, I and II, depending on whether they catalyze reactions involving the breakage of one or both strands of DNA.
Katherine, Evans-Roberts +1 more
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In the past year, the atomic structures of three fragments of type I DNA topoisomerases were elucidated. Together with the atomic structure of a fragment of bacterial gyrase, this wealth of structural information is helping to further our understanding of the mechanism of action of topoisomerases.
A, Sharma, A, Mondragón
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