Results 121 to 130 of about 12,293 (210)

Selenium‐Containing 1,4‐Naphthoquinone Derivatives Trigger Reactive Oxygen Species and Apoptosis in Triple‐Negative Breast Cancer Cells

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT Cancer ranks as a leading cause of death worldwide, demanding new affordable therapies. Nature offers a diverse array of bioactive scaffolds, including 1,4‐naphthoquinone, which serves as a precursor for numerous natural and synthetic compounds with potent antitumor properties.
Eduardo Angulo‐Elizari, Asif Raza, Hannah Johnson, Nuria Martínez‐Sáez, Ignacio Encío, Arun K. Sharma, Carmen Sanmartín, Daniel Plano   +7 more
wiley   +1 more source

The Therapeutic Potential of Stem Cell Therapy for Doxorubicin‐Induced Cardiotoxicity: A Narrative Review

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Aims Doxorubicin (DOX) is a potent anthracycline chemotherapeutic agent whose clinical utility is significantly constrained by severe side effects, most notably DOX‐induced cardiotoxicity (DIC). Pathophysiological mechanisms of DIC include oxidative stress, mitochondrial dysfunction, programmed cell death, and inflammation ...
Ali Mirzaei, Pouria Rezaei, Reza Golchin Vafa, Saleheh Jahani, Reza Arefnezhad, Hossein Fatemian, Mohammad Hossein Nikoo, Amirhossein Sahebkar, Fatemeh Rezaei‐Tazangi   +8 more
wiley   +1 more source

Type II DNA Topoisomerases Cause Spontaneous Double-Strand Breaks in Genomic DNA. [PDF]

Genes (Basel), 2019
Morimoto S, Tsuda M, Bunch H, Sasanuma H, Austin C, Takeda S.   +5 more
europepmc   +1 more source

Goniothalamin as a Styryl‐Lactone Toxicophore in Cancer Models: Electrophile‐Driven DNA Damage, Reactive Oxygen Species–Endoplasmic Reticulum Stress Signaling and Detoxification‐Relevant Safety Considerations

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Goniothalamin (GTN) exerts anticancer effects by promoting reactive oxygen species (ROS) generation, glutathione (GSH) depletion, DNA damage, endoplasmic reticulum (ER) stress, and mitochondrial dysfunction. These interconnected events trigger apoptosis, necroptosis, anoikis, and autophagy, while modulating mitogen‐activated protein kinase (MAPK ...
Nataša Joković, Strahinja Pešić, Marija Novaković, Anđela Dubroja Krstić, William N. Setzer, Javad Sharifi‐Rad, Daniela Calina   +6 more
wiley   +1 more source

Water Soluble‐Nitrogenous Secondary Metabolites From Talaromyces annesophieae MD2 Exhibit Anti‐Bacterial, Anti‐Cancer, Anti‐Oxidant, and Cytoprotective Activities

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
The dichloromethane extract (DCM‐E) was prepared from the culture supernatant of the fungus Talaromyces annesophieae MD2 was fractionated using chromatographic techniques. The subfraction 3 was determined to contain four major nitrogenous compounds and exhibit antibacterial, anticancer, antioxidant, and cytoprotective activities.
Meryem Doymus‐Yilmaz, Huseyin Aksit, Mesut Taskin   +2 more
wiley   +1 more source

Cellular DNA Topoisomerases Are Required for the Synthesis of Hepatitis B Virus Covalently Closed Circular DNA. [PDF]

J Virol, 2019
Sheraz M, Cheng J, Tang L, Chang J, Guo JT.   +4 more
europepmc   +1 more source

Antibody–Drug Conjugates and Peptide–Drug Conjugates: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 8, August 2026.
The graphic summarizes the design principles, intracellular trafficking, clinical progress, challenges, and future directions of antibody–drug conjugates (ADCs) and peptide–drug conjugates (PDCs). ADCs consist of a tumor‐targeting antibody, a chemical linker, and a potent payload, whereas PDCs use peptide ligands to deliver cytotoxic, radionuclide, or ...
Ruxi Zheng, Shuiquan Li, Zhigang Zhang, Mengke Niu, Jing Fei, Jiaojiao Zhang, Jianwei Zhou, Kongming Wu, Ming Yi, Tianye Li   +9 more
wiley   +1 more source

Chemical Profiling and In Vitro Assessment of Antioxidant and Antimicrobial Properties of Algerian Erica arborea L. Extracts, Strengthened by Molecular Modeling Analysis

ChemistryOpen, Volume 15, Issue 8, August 2026.
Erica arborea L. from Algeria was valorized via chemical profiling and bioactivity assessment. The EtOAc extract showed the highest levels of polyphenols, flavonoids, and flavonols. It exhibited strong antioxidant (ABTS•+, DPPH•, FRAP) and antibacterial activity (S. aureus, B. subtilis).
Amina Bramki, Ouided Benslama, Fatima Zohra Makhlouf, Anna Andolfi, Zineb Mokhbi, Selsabile Nedjaoum, Chawki Bensouici, Maria Michela Salvatore, Marco Masi   +8 more
wiley   +1 more source

An interbacterial cysteine protease toxin inhibits cell growth by targeting type II DNA topoisomerases GyrB and ParE. [PDF]

PLoS Biol
Song PY, Tsai CE, Chen YC, Huang YW, Chen PP, Wang TH, Hu CY, Chen PY, Ku C, Hsia KC, Ting SY.   +10 more
europepmc   +1 more source

Natural Compounds as Anticancer Agents Targeting DNA Topoisomerases. [PDF]

Curr Genomics, 2017
Jain CK, Majumder HK, Roychoudhury S.
europepmc   +1 more source