Results 101 to 110 of about 256,848 (381)
Advanced Healthcare Materials, EarlyView.This study reports a novel strategy for preparing a biocompatible adhesive hydrogel crosslinked with a muscle tissue‐derived extracellular matrix (MEM) for in situ muscle regeneration. As a natural crosslinker, MEM not only mediates combinatorial polymer networks but also stimulates satellite cells to induce a cell‐free therapeutic solution.
Eun Je Jeon +6 more
wiley +1 more source
The CCCTC-binding factor (CTCF) of Drosophila contributes to the regulation of the ribosomal DNA and nucleolar stability. [PDF]
PLoS ONE, 2011 In the repeat array of ribosomal DNA (rDNA), only about half of the genes are actively transcribed while the others are silenced. In arthropods, transposable elements interrupt a subset of genes, often inactivating transcription of those genes. Little is
Paola A Guerrero, Keith A Maggert
doaj +1 more source
Chromosomal rearrangements and transposable elements in locally adapted island Drosophila [PDF]
arXiv, 2021 Chromosomal rearrangements, particularly those mediated by transposable elements (TEs), can drive adaptive evolution by creating chimeric genes, inducing de novo gene formation, or altering gene expression. Here, we investigate rearrangements evolutionary role during habitat shifts in two locally adapted populations, Drosphila santomea and Drosphila ...
arxiv
Evolutionary genomics of transposable elements in Saccharomyces cerevisiae [PDF]
Carr M, Bensasson D, Bergman CM (2012) Evolutionary Genomics of
Transposable Elements in Saccharomyces cerevisiae. PLoS ONE 7(11): e50978, 2012 Saccharomyces cerevisiae is one of the premier model systems for studying the genomics and evolution of transposable elements. The availability of the S. cerevisiae genome led to many insights into its five known transposable element families (Ty1-Ty5) in the years shortly after its completion.
arxiv +1 more source
DNA modification of a maize transposable element correlates with loss of activity. [PDF]
Proceedings of the National Academy of Sciences, 1986 An unstable allele of the bronze 2 (bz2) locus was isolated from a Robertson's Mutator Zea mays line containing a family of active transposable Mu elements. This mutation is somatically unstable, resulting in numerous revertant purple sectors on a bronze kernel. By following the variegated kernel phenotype through two generations, several lineages have
Virginia Walbot, Vicki L. Chandler
openaire +3 more sources
Advanced Science, EarlyView.A region‐wise functional connectivity dynamics (FCD) switching index (RFSI) identifies abnormal drivers in ASD across development, linked to salience/ventral attention, default mode, and frontoparietal networks. RFSI changes correlate with transcriptomic and neurotransmitter profiles, and supported by gene‐edited ASD monkeys.
Wei Li +11 more
wiley +1 more source
BMC Genomics, 2017 Background Switchgrass is a crop with many desirable traits for bioenergy production. Plant genomes have high DNA methylation levels throughout genes and transposable elements and DNA methylation is known to play a role in silencing transposable elements.
Mollee Dworkin +4 more
doaj +1 more source
Transposable elements drive widespread expression of oncogenes in human cancers
Nature Genetics, 2019 Transposable elements (TEs) are an abundant and rich genetic resource of regulatory sequences1–3. Cryptic regulatory elements within TEs can be epigenetically reactivated in cancer to influence oncogenesis in a process termed onco-exaptation4.
H. S. Jang +12 more
semanticscholar +1 more source
Cross-Regulation between Transposable Elements and Host DNA Replication [PDF]
Viruses, 2017 Transposable elements subvert host cellular functions to ensure their survival. Their interaction with the host DNA replication machinery indicates that selective pressures lead them to develop ancestral and convergent evolutionary adaptations aimed at conserved features of this fundamental process.
openaire +3 more sources
Advanced Science, EarlyView.Based on a well‐established in vitro directed differentiation model and an integrated analysis of high‐density cell lineage trees (CLTs) and single‐cell transcriptomes, it is demonstrated that many subclones are formed by sub‐CLTs resembling each other in terms of both cell type compositions and topological structures.
Xiaoyu Zhang +14 more
wiley +1 more source