Results 81 to 90 of about 4,232,910 (194)

Ancient and novel small RNA pathways compensate for the loss of piRNAs in multiple independent nematode lineages.

PLoS Biology, 2015
Small RNA pathways act at the front line of defence against transposable elements across the Eukaryota. In animals, Piwi interacting small RNAs (piRNAs) are a crucial arm of this defence.
Peter Sarkies, Murray E Selkirk, John T Jones, Vivian Blok, Thomas Boothby, Bob Goldstein, Ben Hanelt, Alex Ardila-Garcia, Naomi M Fast, Phillip M Schiffer, Christopher Kraus, Mark J Taylor, Georgios Koutsovoulos, Mark L Blaxter, Eric A Miska   +14 more
doaj   +1 more source

In silico reversal of repeat-induced point mutation (RIP) identifies the origins of repeat families and uncovers obscured duplicated genes [PDF]

, 2010
Background: Repeat-induced point mutation (RIP) is a fungal genome defence mechanism guarding against transposon invasion. RIP mutates the sequence of repeated DNA and over time renders the affected regions unrecognisable by similarity search tools such ...
Hane, J., Oliver, Richard, James K Hane, Richard P Oliver, Oliver, R.P., Hane James K, Hane, J.K., Oliver Richard P   +7 more
core   +1 more source

Functional Investigation of a Novel PIWIL4 Mutation in Nonobstructive Azoospermia During the First Wave of Spermatogenesis

Biomolecules
PIWI-interacting RNAs (piRNAs) are small noncoding RNAs that are almost exclusively expressed in germ cells to silence harmful transposons to maintain genome stability. PIWIL4 is guided by its associated piRNAs to transposable elements, where it recruits
Xiayu Wang, Qian Du, Wanqian Li, Zhongyu Zou, Chikun Wang, Yan Zhou, Zhibin Hu, Yayun Gu, Feng Li   +8 more
doaj   +1 more source

Population scale mapping of transposable element diversity reveals links to gene regulation and epigenomic variation

eLife, 2016
Variation in the presence or absence of transposable elements (TEs) is a major source of genetic variation between individuals. Here, we identified 23,095 TE presence/absence variants between 216 Arabidopsis accessions. Most TE variants were rare, and we
Tim Stuart, Steven R Eichten, Jonathan Cahn, Yuliya V Karpievitch, Justin O Borevitz, Ryan Lister   +5 more
doaj   +1 more source

The latent cis-regulatory potential of mobile DNA in Escherichia coli

Nature Communications
Transposable elements can alter gene regulation in their host genome, either when they integrate into a genome, or when they accrue mutations after integration.
Timothy Fuqua, Andreas Wagner
doaj   +1 more source

Evolution of sequence-specific anti-silencing systems in Arabidopsis

Nature Communications, 2017
Eukaryotes often silence transposable elements (TEs) via DNA methylation. Here, the authors show that evolution of VANC, an Arabidopsis anti-silencing factor, and its target motifs allows sequence-specific demethylation, suggesting a way TEs can ...
Aoi Hosaka, Raku Saito, Kazuya Takashima, Taku Sasaki, Yu Fu, Akira Kawabe, Tasuku Ito, Atsushi Toyoda, Asao Fujiyama, Yoshiaki Tarutani, Tetsuji Kakutani   +10 more
doaj   +1 more source

Celebrating DNA Day with transposable elements.

https://communities.springernature.com/posts/celebrating-dna-day-with-transposable ...
Rebollo, Rita, Goubert, Clément
core   +4 more sources

Role of Retroelements in Frontotemporal Dementia Development

Frontiers in Bioscience-Scholar
Frontotemporal dementia (FTD) develops in proteinopathies involving TDP-43 (transactive response DNA-binding protein 43 kDa), tau, and FUS (fused in sarcoma) proteins, which possess antiviral properties and exert inhibitory effects on human transposable ...
Rustam Nailevich Mustafin
doaj   +1 more source

Extrachromosomal Circular DNA and Transposable Elements in Type 2 Diabetes

International Journal of Molecular Sciences
Type 2 Diabetes (T2D) is a complex disease that arises from interaction between genetic and environmental factors. The activation of transposable elements (TEs) and the production of circular extrachromosomal DNA (eccDNA) may represent genetic mechanisms involved in cellular aging, metabolic alterations, and T2D development through distinct pathways ...
Celeste Moya-Valera, Alex Fernando Arita, Francisco Lara-Hernández, Ana-Bárbara García-García, Felipe Javier Chaves   +4 more
openaire   +2 more sources

Transposable elements expressed in root transcriptome.

, 2018
The pie chart presents the different classes of the transposable elements expressed in the root tissues. The numbers after the transposon class are the number of transcripts in each class expressed in the root transcriptome.
Wanlong Li (102234), Ghana Shyam Challa (5931602)   +1 more
core   +1 more source