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From Methylomes to CRISPR Epigenetic Editing: New Paths in Antibiotic Resistance [PDF]

open access: yesPathogens
Antibiotic resistance (AR) has long been interpreted through the lens of genetic mutations and horizontal gene transfer. Yet, mounting evidence suggests that epigenetic regulation, including DNA and RNA methylation, histone-like proteins, and small non ...
Nada M. Nass, Kawther A. Zaher
doaj   +2 more sources

Grass Meal Acts as a Probiotic in Chicken

open access: yesMicrobiology Research, 2023
Probiotics can act as an alternative to antibiotics in animal feeding, but their use is minimal due to their expensive production. Dry grass is rich with bacteria beneficial for animal feeding and can be used as a probiotic.
Elena S. Bogdanova   +7 more
doaj   +1 more source

Complete genome assembly and methylome dissection of Methanococcus aeolicus PL15/Hp

open access: yesFrontiers in Microbiology, 2023
Although restriction-modification systems are found in both Eubacterial and Archaeal kingdoms, comparatively less is known about patterns of DNA methylation and genome defense systems in archaea.
Alexey Fomenkov   +4 more
doaj   +1 more source

Non-Association of Driver Alterations in PTEN with Differential Gene Expression and Gene Methylation in IDH1 Wildtype Glioblastomas

open access: yesBrain Sciences, 2023
During oncogenesis, alterations in driver genes called driver alterations (DAs) modulate the transcriptome, methylome and proteome through oncogenic signaling pathways.
Mrinmay Kumar Mallik   +2 more
doaj   +1 more source

Integration of Transcriptome and Methylome Highlights the Roles of Cell Cycle and Hippo Signaling Pathway in Flatfish Sexual Size Dimorphism

open access: yesFrontiers in Cell and Developmental Biology, 2021
Sexual size dimorphism (SSD) is the difference in segments or body size between sexes prevalent in various species. Understanding the genetic architecture of SSD has remained a significant challenge owing to the complexity of growth mechanisms and the ...
Na Wang   +23 more
doaj   +1 more source

Genome wide exploration of the methylome in aggressive B-cell lymphoma in Golden Retrievers reveals a conserved hypermethylome

open access: yesEpigenetics, 2022
Few recurrent DNA mutations are seen in aggressive canine B cell lymphomas (cBCL), suggesting other frequent drivers. The methylated island recovery assay (MIRA-seq) or methylated CpG-binding domain sequencing (MBD-seq) was used to define the genome-wide
Shirley Chu   +3 more
doaj   +1 more source

Whole‐genome DNA methylation patterns of Oryza sativa (L.) and Oryza glumaepatula (Steud) genotypes associated with aluminum response

open access: yesPlant Direct, 2022
Epigenetic mechanisms in crops have emerged as a fundamental factor in plant adaptation and acclimation to biotic and abiotic stresses. Among described epigenetic mechanisms, DNA methylation has been defined as the most studied epigenetic modification ...
Jenny Johana Gallo‐Franco   +5 more
doaj   +1 more source

Differences in the Accessory Genomes and Methylomes of Strains of Streptococcus equi subsp. equi and of Streptococcus equi subsp. zooepidemicus Obtained from the Respiratory Tract of Horses from Texas

open access: yesMicrobiology Spectrum, 2022
Streptococcus equi subsp. equi (SEE) is a host-restricted equine pathogen considered to have evolved from Streptococcus equi subsp. zooepidemicus (SEZ). SEZ is promiscuous in host range and is commonly recovered from horses as a commensal.
Ellen Ruth A. Morris   +4 more
doaj   +1 more source

Case report: Complete paternal isodisomy on chromosome 18 induces methylation changes in PARD6G-AS1 promotor in a case with arthrogryposis

open access: yesFrontiers in Genetics, 2023
Uniparental disomy (UPD) is the inheritance of both alleles of a chromosome from only one parent. So far, the detection of UPDs in sequencing data is not well established and a known gap in next-generation sequencing (NGS) diagnostics.
Johanna Moch   +8 more
doaj   +1 more source

Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications. [PDF]

open access: yes, 2010
Analysis of DNA methylation patterns relies increasingly on sequencing-based profiling methods. The four most frequently used sequencing-based technologies are the bisulfite-based methods MethylC-seq and reduced representation bisulfite sequencing (RRBS),
A Bird   +79 more
core   +5 more sources

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