Results 11 to 20 of about 26,277 (245)
Methylome evolution in plants [PDF]
Genome Biology, 2016 Despite major progress in dissecting the molecular pathways that control DNA methylation patterns in plants, little is known about the mechanisms that shape plant methylomes over evolutionary time. Drawing on recent intra- and interspecific epigenomic studies, we show that methylome evolution over long timescales is largely a byproduct of genomic ...
Vidalis, Amaryllis +5 more
openaire +6 more sources
Single-cell DNA methylation profiling: Technologies, computation, and applications in precision oncology. [PDF]
Mol OncolSingle‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Kim IS.
europepmc +2 more sources
A Pan-Methylome Framework for Population-Scale Bacterial Epigenomics. [PDF]
Adv Sci (Weinh)A scalable quantitative framework unlocks population‐level comparative epigenomics in bacteria. By transforming site‐level data into standardized traits, this approach reconstructs methylation‐informed phylogenies and defines the core epigenome.
Ma B +22 more
europepmc +2 more sources
Decoding the sorghum methylome: understanding epigenetic contributions to agronomic traits [PDF]
, 2022 DNA methylation is a chromatin modification that plays an essential role in regulating gene expression and genome stability and it is typically associated with gene silencing and heterochromatin.
Mace, Emma S. +4 more
core +2 more sources
FEBS Letters, 2010 Complete DNA methylomes for several organisms are now available, helping clarify the evolutionary story of this epigenetic mark and its distribution in key genomic elements. Nonetheless, a complete understanding of its role, the mechanisms responsible for its establishment and maintenance, and its cross talk with other components of cellular machinery ...
Pelizzola, M, Ecker, JR
openaire +2 more sources
Resistance training rejuvenates the mitochondrial methylome in aged human skeletal muscle [PDF]
, 2021 Resistance training (RT) dynamically alters the skeletal muscle nuclear DNA methylome. However, no study has examined if RT affects the mitochondrial DNA (mtDNA) methylome. Herein, ten older, Caucasian untrained males (65 ± 7 y.o.) performed six weeks of
Candow, Darren G +14 more
core +2 more sources
, 2023 Processed DNA methylation data from published paper:Milutin Gašperov, N., Sabol, I., Božinović, K., Dediol, E., Mravak-Stipetić, M., Licastro, D., Dal Monego, S., & Grce, M. (2020).
Katarina Mandić (17546298) +1 more
core +1 more source
Frontiers in Genetics, 2023 Uniparental disomy (UPD) is the inheritance of both alleles of a chromosome from only one parent. So far, the detection of UPDs in sequencing data is not well established and a known gap in next-generation sequencing (NGS) diagnostics.
Johanna Moch +8 more
doaj +1 more source
Epigenomics: Mapping the Methylome [PDF]
Cell Cycle, 2005 DNA methylation is integral to normal development and disease processes. However, the genomic distribution of methylated sequences--the methylome--is poorly understood. We have recently developed a platform technology for rapid assessment of methylation status throughout the human genome in a high-resolution, high-throughput manner. This is achieved by
Wilson, Ian M. +7 more
openaire +2 more sources
The Human Placental Methylome [PDF]
Cold Spring Harbor Perspectives in Medicine, 2015 This review provides an overview of the unique features of DNA methylation in the human placenta. We discuss the importance of understanding placental development, structure, and function in the interpretation of DNA methylation data. Examples are given of how DNA methylation is important in regulating placental-specific gene expression, including ...
Wendy P, Robinson, E Magda, Price
openaire +2 more sources