Results 31 to 40 of about 26,277 (245)
Epigenetics, 2021 A newly-developed platform, the Illumina TruSeq Methyl Capture EPIC library prep (TruSeq EPIC), builds on the content of the Infinium MethylationEPIC Beadchip Microarray (EPIC-array) and leverages the power of next-generation sequencing for targeted ...
Nan Lin +7 more
doaj +1 more source
Comparison of Yersinia enterocolitica DNA Methylation at Ambient and Host Temperatures
Epigenomes, 2023 Pathogenic bacteria recognize environmental cues to vary gene expression for host adaptation. Moving from ambient to host temperature, Yersinia enterocolitica responds by immediately repressing flagella synthesis and inducing the virulence plasmid (pYV ...
Dustin J. Van Hofwegen +2 more
doaj +1 more source
Cell-free DNA methylome profiling by MBD-seq with ultra-low input
Epigenetics, 2022 Methylation signatures in cell-free DNA (cfDNA) have shown great sensitivity and specificity in the characterization of tumour status and classification of tumour types, as well as the response to therapy and recurrence. Currently, most cfDNA methylation
Jinyong Huang +2 more
doaj +1 more source
The human placenta methylome [PDF]
Proceedings of the National Academy of Sciences, 2013 Tissue-specific DNA methylation is found at promoters, enhancers, and CpG islands but also over larger genomic regions. In most human tissues, the vast majority of the genome is highly methylated (>70%). Recently, sequencing of bisulfite-treated DNA (MethylC-seq) has revealed large partially methylated domains (PMDs) in some human cell lines.
Diane I, Schroeder +10 more
openaire +2 more sources
Frontiers in Genetics, 2021 Polycystic ovary syndrome (PCOS) is the most common complex endocrine and metabolic disease in women of reproductive age. It is characterized by anovulatory infertility, hormone disorders, and polycystic ovarian morphology.
Rusong Zhao +15 more
doaj +1 more source
Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses. [PDF]
Adv Sci (Weinh)Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Li L +8 more
europepmc +2 more sources
Frontiers in Marine Science, 2023 DNA methylation is a critical epigenetic modification that dynamically regulates gene expression in organisms facing abiotic stress. However, few studies have comprehensively examined the role of DNA methylation in marine fish during environmental ...
Jian Yang +5 more
doaj +1 more source
Frontiers in Microbiology, 2023 Restriction modification (RM) systems are known to provide a strong barrier to the exchange of DNA between and within bacterial species. Likewise, DNA methylation is known to have an important function in bacterial epigenetics regulating essential ...
Carolin J. Schiffer +4 more
doaj +1 more source
THE METHYLOME OF YERSINIA PESTIS [PDF]
, 2015 During the normal cycle of transfer between its vector (the flea) and a mammalian host, Yersinia pestis (Y. pestis) is exposed to significantly different environmental conditions. Studies have shown gene expression patterns in Y.
Hnath, Jonathan
core +1 more source
Frontiers in Oncology, 2023 Despite distant metastases being the critical factor affecting patients’ survival, they remain poorly understood. Our study thus aimed to molecularly characterize colorectal cancer liver metastases (CRCLMs) and explore whether molecular profiles differ ...
Josef Horak +22 more
doaj +1 more source