Results 21 to 30 of about 37,526 (188)

Plant-RRBS, a bisulfite and next-generation sequencing-based methylome profiling method enriching for coverage of cytosine positions [PDF]

, 2017
Background: Cytosine methylation in plant genomes is important for the regulation of gene transcription and transposon activity. Genome-wide methylomes are studied upon mutation of the DNA methyltransferases, adaptation to environmental stresses or ...
A Akalin, A Meissner, A Verkest, AJ Bewick, AR Elhamamsy, AR Quinlan, B Langmead, Bram Slabbinck, C Becker, CA Ibarra, Cindy Martens, D Meng, D Pignatta, EJ Finnegan, F Johannes, Frederik Coppens, G Gremme, H Parkinson, H Saze, H Schöb, H Stroud, H Zhang, H-Q Wang, HJ Xie, International Rice Genome Sequencing Project, J Du, J Yu, JI Gent, K Manning, K Okonechnikov, M Block De, M Block De, M Choi, M Hauben, M Schmidt, Magdalena Woloszynska, Marc De Block, Martin Schmidt, MD Schultz, MG Murray, Michiel Van Bel, Mieke Van Lijsebettens, P Cubas, PF Gugger, PS Schnable, R Lister, RJ Schmitz, SE Jacobsen, SJ Cokus, T-F Hsieh, The Arabidopsis Genome Initiative, TJ Treangen, TP Gurp van, W Guo, X Cao, X Chen, X Li, X Wang, X Zhang, ZD Smith, ZL Liu   +60 more
core   +3 more sources

Cell-free DNA methylome profiling by MBD-seq with ultra-low input

Epigenetics, 2022
Methylation signatures in cell-free DNA (cfDNA) have shown great sensitivity and specificity in the characterization of tumour status and classification of tumour types, as well as the response to therapy and recurrence. Currently, most cfDNA methylation
Jinyong Huang, Alex C. Soupir, Liang Wang   +2 more
doaj   +1 more source

DNA methylation-associated colonic mucosal immune and defense responses in treatment-naïve pediatric ulcerative colitis [PDF]

, 2014
Inflammatory bowel diseases (IBD) are emerging globally, indicating that environmental factors may be important in their pathogenesis. Colonic mucosal epigenetic changes, such as DNA methylation, can occur in response to the environment and have been ...
Bronsky, Jiri, Ferry, George D., Frank, Eibe, Harris, R. Alan, Kaplan, Jess L., Kellermayer, Richard, Mir, Sabina A.V., Nagy-Szakal, Dorottya, Opekun, Antone, Szigeti, Reka, Winter, Harland   +10 more
core   +2 more sources

Comparison of EM-seq and PBAT methylome library methods for low-input DNA

Epigenetics, 2022
DNA methylation is the most studied epigenetic mark involved in regulation of gene expression. For low input samples, a limited number of methods for quantifying DNA methylation genome-wide has been evaluated.
Yanan Han, Galina Yurevna Zheleznyakova, Yanara Marincevic-Zuniga, Majid Pahlevan Kakhki, Amanda Raine, Maria Needhamsen, Maja Jagodic   +6 more
doaj   +1 more source

Multiomics Analysis Reveals Molecular Abnormalities in Granulosa Cells of Women With Polycystic Ovary Syndrome

Frontiers in Genetics, 2021
Polycystic ovary syndrome (PCOS) is the most common complex endocrine and metabolic disease in women of reproductive age. It is characterized by anovulatory infertility, hormone disorders, and polycystic ovarian morphology.
Rusong Zhao, Rusong Zhao, Rusong Zhao, Rusong Zhao, Yonghui Jiang, Yonghui Jiang, Yonghui Jiang, Yonghui Jiang, Shigang Zhao, Shigang Zhao, Shigang Zhao, Shigang Zhao, Han Zhao, Han Zhao, Han Zhao, Han Zhao   +15 more
doaj   +1 more source

Transcriptome and methylome dynamics in the gills of large yellow croaker (Larimichthys crocea) during low-salinity adaption

Frontiers in Marine Science, 2023
DNA methylation is a critical epigenetic modification that dynamically regulates gene expression in organisms facing abiotic stress. However, few studies have comprehensively examined the role of DNA methylation in marine fish during environmental ...
Jian Yang, Jian Yang, Minhai Liu, Tingting Zhou, Qi Li, Zhihua Lin   +5 more
doaj   +1 more source

Genome-wide methylome analysis using MethylCap-seq uncovers 4 hypermethylated markers with high sensitivity for both adeno- and squamous-cell cervical carcinoma [PDF]

, 2016
Background: Cytology-based screening methods for cervical adenocarcinoma (ADC) and to a lesser extent squamous-cell carcinoma (SCC) suffer from low sensitivity.
Boers, Aniek, De Meyer, Tim, Klip, Harry G, Schuuring, Ed, Steenbergen, Renske DM, Van Criekinge, Wim, van der Zee, Ate GJ, van Leeuwen, Robert W, Wang, Rong, Wisman, G Bea A   +9 more
core   +2 more sources

The catalytic core of DEMETER guides active DNA demethylation in Arabidopsis. [PDF]

, 2019
The Arabidopsis DEMETER (DME) DNA glycosylase demethylates the maternal genome in the central cell prior to fertilization and is essential for seed viability.
Aravind, L., Fischer, Robert L., Frost, Jennifer M., Hsieh, Tzung-Fu, Huh, Jin Hoe, Hung, Yu-Hung, Iyer, Lakshminarayan M., Jang, Hosung, Liu, Fang, Rim, Hyun Jung, Shin, Hosub, Xiao, Wenyan, Zhang, Changqing, Zhang, Dapeng, Zhang, Xiang-Qian, 허진회   +15 more
core   +2 more sources

Characterization of the Staphylococcus xylosus methylome reveals a new variant of type I restriction modification system in staphylococci

Frontiers in Microbiology, 2023
Restriction modification (RM) systems are known to provide a strong barrier to the exchange of DNA between and within bacterial species. Likewise, DNA methylation is known to have an important function in bacterial epigenetics regulating essential ...
Carolin J. Schiffer, Christian Grätz, Michael W. Pfaffl, Rudi F. Vogel, Matthias A. Ehrmann   +4 more
doaj   +1 more source

The Personal Genome Project-UK, an open access resource of human multi-omics data [PDF]

, 2019
Integrative analysis of multi-omics data is a powerful approach for gaining functional insights into biological and medical processes. Conducting these multifaceted analyses on human samples is often complicated by the fact that the raw sequencing output
Beck, Stephan, Berner, Alison, Chervova, Olga, Conde, Lucia, Guerra-Assunção, José Afonso, Hamoudi, Rifat, Herrero, Javier, Jesus, Tiago F., Larose Cadieux, Elizabeth, Moghul, Ismail, Tian, Yuan, Voloshin, Vitaly, Webster, Amy P.   +12 more
core   +2 more sources