Results 61 to 70 of about 62,579 (262)

Transposon insertion profiling by sequencing (TIPseq) for mapping LINE-1 insertions in the human genome

Mobile DNA, 2019
Background Transposable elements make up a significant portion of the human genome. Accurately locating these mobile DNAs is vital to understand their role as a source of structural variation and somatic mutation. To this end, laboratories have developed
Jared P. Steranka, Zuojian Tang, Mark Grivainis, Cheng Ran Lisa Huang, Lindsay M. Payer, Fernanda O. R. Rego, Thiago Luiz Araujo Miller, Pedro A. F. Galante, Sitharam Ramaswami, Adriana Heguy, David Fenyö, Jef D. Boeke, Kathleen H. Burns   +12 more
doaj   +1 more source

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

Comprehensive analysis of the Xya riparia genome uncovers the dominance of DNA transposons, LTR/Gypsy elements, and their evolutionary dynamics

BMC Genomics
Transposable elements (TEs) are DNA sequences that can move or replicate within a genome, and their study has become increasingly important in understanding genome evolution and function.
Hashim Khan, Huang Yuan, Xuanzeng Liu, Yimeng Nie, Muhammad Majid   +4 more
doaj   +1 more source

Genome‐Wide In Vivo RNAi Screening Identifies HOXD4 as a Tumor Metastasis Suppressor in Colorectal Cancer

Advanced Science, EarlyView.
Metastasis remains a major challenge in colorectal cancer. Using an in vivo shRNA screening system, this study identifies Homeobox D4 as a key metastasis suppressor. Reduced Homeobox D4 expression is associated with aggressive tumor features. Functional and mechanistic analyses show that it inhibits epithelial‐mesenchymal transition by repressing ...
Zhi‐hua Ye, Wen‐jing Luo, Lu Li, Wen‐di Shuai, Ling Zhou, You‐fa Duan, Xue Chen, Jun‐kai Zhang, Wenlin Huang, Ran‐yi Liu   +9 more
wiley   +1 more source

Unraveling the role of satellite DNAs in the evolution of the giant XY sex chromosomes of the flea beetle Omophoita octoguttata (Coleoptera, Chrysomelidae)

BMC Biology
Background The flea beetle Omophoita octoguttata (Coleoptera, Chrysomelidae) is a member of a group in which the males completely lack meiotic recombination (male-specific achiasmy) and that have extraordinarily large X and Y chromosomes.
Jhon Alex Dziechciarz Vidal, Deborah Charlesworth, Ricardo Utsunomia, Manuel A. Garrido-Ramos, Rodrigo Zeni dos Santos, Fábio Porto-Foresti, Roberto Ferreira Artoni, Thomas Liehr, Mara Cristina de Almeida, Marcelo de Bello Cioffi   +9 more
doaj   +1 more source

Enhancer activation from transposable elements in extrachromosomal DNA

Nature Cell Biology
Abstract Extrachromosomal DNA (ecDNA) drives oncogene amplification and intratumoral heterogeneity in aggressive cancers. While transposable element (TE) reactivation is common in cancer, its role on ecDNA remains unexplored.
Katerina Kraft, Sedona E. Murphy, Matthew G. Jones, Quanming Shi, Aarohi Bhargava-Shah, Christy Luong, King L. Hung, Britney J. He, Rui Li, Seung Kuk Park, Michael T. Montgomery, Natasha E. Weiser, Yanbo Wang, Jens Luebeck, Vineet Bafna, Jef D. Boeke, Paul S. Mischel, Alistair N. Boettiger, Howard Y. Chang   +18 more
openaire   +4 more sources

Unveiling Lactylation: A Novel Frontier in Cancer Stemness and Therapy

Advanced Science, EarlyView.
Tumor metabolism and epigenetic regulation are intrinsically linked. This review highlights lactylation as a pivotal bridge connecting these processes, acting as an active epigenetic effector in cancer stemness. We delineate how lactylation orchestrates the cancer stem cell landscape and evaluate its regulatory networks.
Ting Li, Hongyu Gu, Chang Liu, Yuesheng Lv, Feifei Li, Liang Liang, Jia Yi, Xuanyi Wang, Yi Zhun Zhu, Chuan Xu   +9 more
wiley   +1 more source

Sequences Related to Transposable Elements and Bacteriophages Flank Avirulence Genes of Pseudomonas syringae

Molecular Plant-Microbe Interactions, 1998
Examination of the reported nucleotide sequences containing avirulence genes of Pseudomonas syringae pathovars suggested that avrA, avrB, avrC, avrPphC, avrRpm1, and avrPpiA1 are bordered by sequences similar to those of transposable elements of gram ...
Jihyun F. Kim, Amy O. Charkowski, James R. Alfano, Alan Collmer, Steven V. Beer   +4 more
doaj   +1 more source

Two Routes to Land: Genomic Underpinnings of Parallel Aerial Egg Deposition in Aquatic Old‐World Pila and New‐World Pomacea (Ampullariidae)

Advanced Science, EarlyView.
Comparative genomics of Gondwana‐diverged Pila and Pomacea reveals parallel evolution of aerial oviposition. Convergent chromosomal rearrangements reshape regulatory landscapes within topologically associating domains. Lineage‐specific gene family expansions and viral‐derived perivitelline proteins (PV1) underpin desiccation resistance.
Yufei Zhou, Huawei Mu, Xueying Nie, Yue Gao, Hui Wang, Ling Fang, Tiangang Luan, Monthon Ganmanee, Jian‐Wen Qiu, Jin Sun, Jack Chi‐Ho Ip   +10 more
wiley   +1 more source

Bifidobacterium Pseudolongum‐Derived Inosine Mitigates Polystyrene Nanoplastics‐Induced Hepatic Injury by Inhibiting the Polarization of M1 Macrophages

Advanced Science, EarlyView.
Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang, Yuchuan Chen, Jiayuan Wan, Jianzheng Yang, Lijian Chen, Qingyuan Li, Anding Zhou, Nian Zhou, Jiuyang Ding, Qi Wang, Jian Sun   +10 more
wiley   +1 more source