Results 41 to 50 of about 92,871 (296)

Copy number-dependent DNA methylation of the Pyricularia oryzae MAGGY retrotransposon is triggered by DNA damage

Communications Biology, 2021
Ba Van Vu, Quyet Nguyen et al. investigate the mechanism by which transposable elements are targeted for DNA methylation, using the fungus Pyricularia oryzae as a model system.
Ba Van Vu, Quyet Nguyen, Yuki Kondo-Takeoka, Toshiki Murata, Naoki Kadotani, Giang Thi Nguyen, Takayuki Arazoe, Shuichi Ohsato, Hitoshi Nakayashiki   +8 more
doaj   +1 more source

Transposable Elements: From DNA Parasites to Architects of Metazoan Evolution [PDF]

Genes, 2012
One of the most unexpected insights that followed from the completion of the human genome a decade ago was that more than half of our DNA is derived from transposable elements (TEs). Due to advances in high throughput sequencing technologies it is now clear that TEs comprise the largest molecular class within most metazoan genomes.
Piskurek, Oliver, Jackson, Daniel John
openaire   +4 more sources

MBD2 couples DNA methylation to transposable element silencing during male gametogenesis

Nature Plants, 2023
Abstract DNA methylation is an essential component of transposable element (TE) silencing, yet the mechanism by which methylation causes transcriptional repression remains poorly understood 1–5 .
Shuya Wang, Ming Wang, Lucia Ichino, Brandon A. Boone, Zhenhui Zhong, Ranjith K. Papareddy, Evan K. Lin, Jaewon Yun, Suhua Feng, Steven E. Jacobsen   +9 more
openaire   +4 more sources

Widespread contribution of transposable elements to the rewiring of mammalian 3D genomes

Nature Communications, 2023
Here the authors show transposable elements, formerly considered junk DNA, are a source of CTCF binding sites that contribute to species-specific 3D-genome structure, and may impact gene regulation during the course of mammalian evolution.
Mayank N. K. Choudhary, Kara Quaid, Xiaoyun Xing, Heather Schmidt, Ting Wang   +4 more
doaj   +1 more source

Shedding light on DNA methylation and its clinical implications: the impact of long-read-based nanopore technology

Epigenetics & Chromatin
DNA methylation is an essential epigenetic mechanism for regulation of gene expression, through which many physiological (X-chromosome inactivation, genetic imprinting, chromatin structure and miRNA regulation, genome defense, silencing of transposable ...
Alexandra Chera, Mircea Stancu-Cretu, Nicolae Radu Zabet, Octavian Bucur   +3 more
doaj   +1 more source

DNA methylation dynamics during early plant life

Genome Biology, 2017
Background Cytosine methylation is crucial for gene regulation and silencing of transposable elements in mammals and plants. While this epigenetic mark is extensively reprogrammed in the germline and early embryos of mammals, the extent to which DNA ...
Daniel Bouyer, Amira Kramdi, Mohamed Kassam, Maren Heese, Arp Schnittger, François Roudier, Vincent Colot   +6 more
doaj   +1 more source

Single-molecule real-time sequencing combined with optical mapping yields completely finished fungal genome [PDF]

, 2015
Next-generation sequencing (NGS) technologies have increased the scalability, speed, and resolution of genomic sequencing and, thus, have revolutionized genomic studies.
Datema, Erwin, Faino, Luigi, Janssen, Antoine, Seidl, Michael F., Thomma, Bart P. H. J., Van Den Berg, Grardy C. M., Wittenberg, Alexander H. J.   +6 more
core   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

A new reference genome assembly for the microcrustacean Daphnia pulex [PDF]

, 2017
Comparing genomes of closely related genotypes from populations with distinct demographic histories can help reveal the impact of effective population size on genome evolution. For this purpose, we present a high quality genome assembly of Daphnia pulex (
Ackerman, Matthew S, Asselman, Jana, Harker, Brent, Jiang, Xiaoqian, Lopez, Jacqueline, Lynch, Michael, Pfrender, Michael E, Raborn, R Taylor, Ramsdell, Jordan, Spitze, Ken, Thomas, W Kelley, Xu, Sen, Ye, Zhiqiang   +12 more
core   +3 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source