Results 141 to 150 of about 256,848 (381)

Targeting miRNA‐1a and miRNA‐15b: A Novel Combinatorial Strategy to Drive Adult Cardiac Regeneration

Advanced Science, EarlyView.
The article explores a novel therapeutic strategy for cardiac regeneration by targeting miRNA‐1a and miRNA‐15b. Combinatorial inhibition of miR‐1a and miR‐15b enhances cardiomyocyte proliferation, improves heart function, and reduces fibrosis in myocardial infarction models.
Ting Yuan, Meiqian Wu, Chaonan Zhu, Hao Yu, Minh Duc Pham, Katharina Bottermann, Yijie Mao, Yue Wang, Mathias Langner, Mirko Peitzsch, Arka Provo Das, Silke Kauferstein, Jonathan Ward, Peter Mirtschink, Andreas Michael Zeiher, Stefanie Dimmeler, Jaya Krishnan   +16 more
wiley   +1 more source

Unraveling the role of satellite DNAs in the evolution of the giant XY sex chromosomes of the flea beetle Omophoita octoguttata (Coleoptera, Chrysomelidae)

BMC Biology
Background The flea beetle Omophoita octoguttata (Coleoptera, Chrysomelidae) is a member of a group in which the males completely lack meiotic recombination (male-specific achiasmy) and that have extraordinarily large X and Y chromosomes.
Jhon Alex Dziechciarz Vidal, Deborah Charlesworth, Ricardo Utsunomia, Manuel A. Garrido-Ramos, Rodrigo Zeni dos Santos, Fábio Porto-Foresti, Roberto Ferreira Artoni, Thomas Liehr, Mara Cristina de Almeida, Marcelo de Bello Cioffi   +9 more
doaj   +1 more source

Dynamic DNA Processing: A Microcode Model of Cell Differentiation [PDF]

arXiv, 2013
A general theoretical framework is put forth to organize and understand various observed phenomena and mathematical relationships in the field of molecular biology. By modeling each cell in eukaryotic organisms as a processor having a unique set of allowed states, represented by a specific DNA sequence, we demonstrate a method by which gene expression ...
arxiv  

The landscape of transposable elements and satellite DNAs in the genome of a dioecious plant spinach (Spinacia oleracea L.)

Mobile DNA, 2019
Repetitive sequences, including transposable elements (TEs) and satellite DNAs, occupy a considerable portion of plant genomes. Analysis of the repeat fraction benefits the understanding of genome structure and evolution.
Shu-Fen Li, Yu-Jiao Guo, Jia-Rong Li, Dong-xu Zhang, Bing-Xiao Wang, Ning Li, C. Deng, W. Gao   +7 more
semanticscholar   +1 more source

Nuclear Translocation of S100A9 Triggers Senescence of Human Amnion Fibroblasts by De‐Repressing LINE1 Via Heterochromatin Erosion at Parturition

Advanced Science, EarlyView.
This study shows that the classical secretory protein S100 calcium‐binding protein A9 (S100A9) can translocate to the nucleus upon de‐phosphorylation at Thr 113 in human amnion fibroblasts at parturition, where S100A9 induces heterochromatin erosion through segregation of the heterochromatin maintenance protein, resulting inLong Interspersed Nuclear ...
Fan Zhang, Meng‐Die Li, Fan Pan, Wen‐Jia Lei, Yang Xi, Li‐Jun Ling, Leslie Myatt, Kang Sun, Wang‐Sheng Wang   +8 more
wiley   +1 more source

A hypothesis on the role of transposons [PDF]

arXiv, 2010
"Epigenetic Tracking" is an evo-devo method to generate arbitrary 2d or 3d shapes; as such, it belongs to the field of "artificial embryology". In silico experiments have proved the effectiveness of the method in devo-evolving shapes of any kind and complexity (in terms of number of cells, number of colours, etc.), establishing its potential to ...
arxiv  

Dynamic Patterns of Transcript Abundance of Transposable Element Families in Maize. [PDF]

, 2019
Transposable Elements (TEs) are mobile elements that contribute the majority of DNA sequences in the maize genome. Due to their repetitive nature, genomic studies of TEs are complicated by the difficulty of properly attributing multi-mapped short reads ...
Anderson, Sarah N, Hirsch, Cory D, Ross-Ibarra, Jeffrey, Springer, Nathan M, Stitzer, Michelle C, Zhou, Peng   +5 more
core  

A machine learning based framework to identify and classify long terminal repeat retrotransposons [PDF]

, 2018
Transposable elements (TEs) are repetitive nucleotide sequences that make up a large portion of eukaryotic genomes. They can move and duplicate within a genome, increasing genome size and contributing to genetic diversity within and across species ...
Blockeel, Hendrik, Carareto, Claudia MA, Cerri, Ricardo, Costa, Eduardo, Fischer, Carlos N, Ramon, Jan, Schietgat, Leander, Vens, Celine   +7 more
core   +5 more sources

Evolution and diversity of transposable elements in fish genomes

Scientific Reports, 2019
Transposable elements (TEs) are genomic sequences that can move, multiply, and often form sizable fractions of vertebrate genomes. Fish belong to a unique group of vertebrates, since their karyotypes and genome sizes are more diverse and complex, with ...
Feng Shao, Minjin Han, Zuogang Peng
semanticscholar   +1 more source

Monitoring the interplay between transposable element families and DNA methylation in maize

PLOS Genetics, 2019
DNA methylation and epigenetic silencing play important roles in the regulation of transposable elements (TEs) in many eukaryotic genomes. A majority of the maize genome is derived from TEs that can be classified into different orders and families based on their mechanism of transposition and sequence similarity, respectively. TEs themselves are highly
Jaclyn M. Noshay, Sarah N. Anderson, Peng Zhou, Lexiang Ji, William Ricci, Zefu Lu, Michelle C. Stitzer, Peter A. Crisp, Candice N. Hirsch, Xiaoyu Zhang, Robert J. Schmitz, Nathan M. Springer   +11 more
openaire   +6 more sources