Results 231 to 240 of about 256,848 (381)
Organocatalytic switches of DNA glycosylase OGG1 catalyze a highly efficient AP‐lyase function
Chemistry – A European Journal, Accepted Article.8‐oxoGuanine DNA glycosylase 1 (OGG1) is the first known target of organocatalytic switches (ORCAs), which rewrite the biochemical function of the enzyme through redirection of its preferred substrate from 8‐oxoG to AP sites. Previously, different ORCA chemotypes were shown to enhance the operational pH window for OGG1, possibly through direct ...
Mario Kehler +28 more
wiley +1 more source
PLANTS, PEOPLE, PLANET, Volume 5, Issue 1, Page 58-69, January 2023., 2023 There are many understudied fruits of great economic and productive importance for regional agricultural hubs. Guava is an American fruit species with attractive nutritional and adaptability characteristics. However, in many countries like Mexico, its cultivation is still limited to small‐to‐medium size plantings and home gardens and depends on poorly ...
Luis Diaz‐Garcia +1 more
wiley +1 more source
Harnessing Viral Proteases for Cellular and Molecular Engineering
Chemistry–Methods, EarlyView.Engineered viral proteases (VIPs) provide programmable control of protein function with high specificity and low toxicity. Integrated with chemogenetic and optogenetic modules, these VIP systems enable logic gate manipulation for targeted regulation of cell signaling, gene expression, protein secretion, and degradation, thereby offering versatile ...
Mingguang Cui +2 more
wiley +1 more source
OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide [PDF]
Hugo Sepúlveda +20 more
openalex +2 more sources
Low coverage sequencing for repetitive DNA analysis in Passiflora edulis Sims: citogenomic characterization of transposable elements and satellite DNA [PDF]
, 2019 Vanessa Carvalho Cayres Pamponét +7 more
openalex +1 more source
Cytometry Part A, EarlyView.ABSTRACT Artificial intelligence (AI) surpasses human accuracy in identifying ordinary objects, but it is still challenging for AI to be competitive in pollen grain identification. One reason for this gap is the extensive trait variation in pollen grains.
Franziska Walther +9 more
wiley +1 more source
Environmental and Molecular Mutagenesis, EarlyView.Abstract As a part of the International Workshop on Genotoxicity Testing (IWGT) in 2022, a workgroup was formed to evaluate the level of validation and regulatory acceptance of transcriptomic biomarkers that identify genotoxic substances. Several such biomarkers have been developed using various molecular techniques and computational approaches. Within
Matthew J. Meier +7 more
wiley +1 more source
Environmental Toxicology and Chemistry, EarlyView.Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers +10 more
wiley +1 more source