Dnmt1 has de novo activity targeted to transposable elements
Nature Structural & Molecular Biology, 2021 DNA methylation plays a critical role during development, particularly in repressing retrotransposons. The mammalian methylation landscape is dependent on the combined activities of the canonical maintenance enzyme Dnmt1 and the de novo Dnmts, 3a and 3b.
Chuck Haggerty +23 more
semanticscholar +1 more source
Transposable elements and circular DNAs [PDF]
Mobile Genetic Elements, 2016 Circular DNAs are extra-chromosomal fragments that become circularized by genomic recombination events. We have recently shown that yeast LTR elements generate circular DNAs through recombination events between their flanking long terminal repeats (LTRs).
openaire +4 more sources
Pathogenic Tau Accelerates Aging-Associated Activation of Transposable Elements in the Mouse Central Nervous System [PDF]
, 2022 Transposable elements comprise almost half of the mammalian genome. A growing body of evidence suggests that transposable element dysregulation accompanies brain aging and neurodegenerative disorders, and that transposable element activation is ...
Beckmann, Adrian +13 more
core +2 more sources
Sensing of transposable elements by the antiviral innate immune system
RNA: A publication of the RNA Society, 2021 Around half of the genomes in mammals are composed of transposable elements (TEs) such as DNA transposons and retrotransposons. Several mechanisms have evolved to prevent their activity and the detrimental impact of their insertional mutagenesis. Despite
A. Gazquez-Gutierrez +3 more
semanticscholar +1 more source
Introduction for the Gene special issue dedicated to the meeting Genomic impact of eukaryotic transposable elements at Asilomar [PDF]
, 2007 The issues related to \u27Genomic Impact of Eukaryotic Transposable Elements\u27, which took place in Pacific Grove, California between March 31st and April 4th 2006, are discussed. The meeting celebrated the extraordinary contributions of Dr.
Batzer, Mark A. +3 more
core +2 more sources
Locus-specific expression of transposable elements in single cells with CELLO-seq
Nature Biotechnology, 2021 Transposable elements (TEs) regulate diverse biological processes, from early development to cancer. Expression of young TEs is difficult to measure with next-generation, single-cell sequencing technologies because their highly repetitive nature means ...
Rebecca V Berrens +11 more
semanticscholar +1 more source
Whole genome resequencing reveals natural target site preferences of transposable elements in Drosophila melanogaster. [PDF]
PLoS ONE, 2012 Transposable elements are mobile DNA sequences that integrate into host genomes using diverse mechanisms with varying degrees of target site specificity.
Raquel S Linheiro, Casey M Bergman
doaj +1 more source
Somatically heritable switches in the DNA modification of Mu transposable elements monitored with a suppressible mutant in maize [PDF]
, 1990 Many transposable elements in maize alternate between active and inactive phases associated with the modification of their DNA. Elements in an inactive phase lose their ability to transpose, their ability to excise from reporter alleles and, in some ...
Barkan, A. +3 more
core +1 more source
Dynamics of transposable elements generates structure and symmetries in genetic sequences [PDF]
Phys. Rev. Research 2, 033477 (2020), 2020 Genetic sequences are known to possess non-trivial composition together with symmetries in the frequencies of their components. Recently, it has been shown that symmetry and structure are hierarchically intertwined in DNA, suggesting a common origin for both features. However, the mechanism leading to this relationship is unknown. Here we investigate a
arxiv +1 more source
The epiallelic potential of transposable elements and its evolutionary significance in plants
Philosophical Transactions of the Royal Society of London. Biological Sciences, 2021 DNA provides the fundamental framework for heritability, yet heritable trait variation need not be completely ‘hard-wired’ into the DNA sequence. In plants, the epigenetic machinery that controls transposable element (TE) activity, and which includes DNA
P. Baduel, V. Colot
semanticscholar +1 more source