Results 81 to 90 of about 93,119 (340)

Sabotaged Integral HSC Heterogeneity Underlies Essential Thrombocythemia Development

Advanced Science, EarlyView.
Single‐cell RNA sequencing (scRNA‐seq) maps how distinct driver mutations remodel hematopoietic stem cell (HSC) programs across essential thrombocythemia (ET). Comparative analysis uncovers both shared and subtype‐specific molecular signatures, identifies a triple‐negative (TN)‐associated HSC population enriched with malignant traits, and reveals the ...
Jingyuan Tong, Di Wang, Haoze Song, Ting Sun, Yanhong Zhao, Wenjing Gu, Lexuan Lin, Yitong Zhao, Yipeng Liang, Xu Jin, Rongfeng Fu, Mankai Ju, Jie Gao, Jinfa Ma, Chengjie Gao, Anqi Zhang, Zhijian Xiao, Erlie Jiang, Renchi Yang, Shihui Ma, Lei Zhang, Lihong Shi   +21 more
wiley   +1 more source

Mangrove Forests: Natural Laboratories for Studying Epigenetic and Climate Changes

Frontiers in Plant Science, 2022
In the adaptation market, plants cash in the changes of their DNA (either genetic or epigenetic) to purchase fitness. Fitness is negatively affected by stressful conditions caused by climate change and well-designed studies are required to investigate ...
Matin Miryeganeh
doaj   +1 more source

Latent regulatory potential of human-specific repetitive elements [PDF]

, 2013
At least half of the human genome is derived from repetitive elements, which are often lineage specific and silenced by a variety of genetic and epigenetic mechanisms. Using a transchromosomic mouse strain that transmits an almost complete single copy of
Barbosa-Morais, Nuno L., Blencowe, Benjamin J., Flicek, Paul, Kirschner, Kristina, Kutter, Claudia, Lukk, Margus, Menon, Suraj, Odom, Duncan T., Pan, Qun, Schmidt, Dominic, Schwalie, Petra C., Stark, Rory, Thybert, David, Ward, Michelle C., Watt, Stephen, Wilson, Michael D.   +15 more
core   +1 more source

Vitamin D Regulates Olfactory Function via Dual Transcriptional and mTOR‐Dependent Translational Control of Synaptic Proteins

Advanced Science, EarlyView.
Vitamin D (VitD) modulates olfactory function by remodeling dendrodendritic synapses in tufted cells through vitamin D receptor‐dependent transcriptional and translational mechanisms. VitD regulates synaptic protein translation partially via mTOR signaling.
Pengcheng Ren, Renhe Cao, Xiaoshan Ye, Wenbin Pang, Qingshang Bi, Meihui Huang, Qionglin Zhou, Dan Ye, Wei Xiang, Le Xiao   +9 more
wiley   +1 more source

Insights into the genome of the ‘Loco’ Concholepas concholepas (Gastropoda: Muricidae) from low-coverage short-read sequencing: genome size, ploidy, transposable elements, nuclear RNA gene operon, mitochondrial genome, and phylogenetic placement in the family Muricidae

BMC Genomics
Background The Peruvian ‘chanque’ or Chilean ‘loco’ Concholepas concholepas is an economically, ecologically, and culturally important muricid gastropod heavily exploited by artisanal fisheries in the temperate southeastern Pacific Ocean.
J. Antonio Baeza, M. Teresa González, Julia D. Sigwart, Carola Greve, Stacy Pirro   +4 more
doaj   +1 more source

Shuffling the yeast genome using CRISPR/Cas9-generated DSBs that target the transposable Ty1 elements

PLoS Genetics, 2023
Although homologous recombination between transposable elements can drive genomic evolution in yeast by facilitating chromosomal rearrangements, the details of the underlying mechanisms are not fully clarified.
Lei Qi, Yang Sui, Xing-Xing Tang, Ryan J. McGinty, Xiao-Zhuan Liang, Margaret Dominska, Ke Zhang, Sergei M. Mirkin, Dao-Qiong Zheng, Thomas D. Petes   +9 more
doaj  

Scattered organization of the histone multigene family and transposable elements in Synbranchus

Genetics and Molecular Biology, 2014
The fish species Synbranchus marmoratus is widely distributed throughout the Neotropical region and exhibits a significant karyotype differentiation. However, data concerning the organization and location of the repetitive DNA sequences in the genomes of
Ricardo Utsunomia, José Carlos Pansonato-Alves, Priscilla Cardim Scacchetti, Claudio Oliveira, Fausto Foresti   +4 more
doaj   +1 more source

Epstein‐Barr Virus Expressed Long Non‐Coding RNA (lncBARTs) Regulate EBV Latent Genome Replication

Advanced Science, EarlyView.
EBV produces abundant level of lncBARTs, which are essential for maintaining viral genome replication in EBV‐associated cancers. LncBARTs interact with a complex comprising BRD4, CTCF and viral protein EBNA1 at EBV oriP region. This interaction tethers oriP to host chromosomes, facilitating EBV episome replication.
Jiayan Liu, Dittman Lai‐Shun Chung, Larry Ka‐Yue Chow, Shuo Han, Wenkai Yi, Conor J. Cremin, Yingyin Liao, Pui Wang, Bobo Wing‐Yee Mok, Mingfang Ji, Jian Yan, Wei Dai, Honglin Chen   +12 more
wiley   +1 more source

A MODEL FOR DNA SEQUENCE EVOLUTION WITHIN TRANSPOSABLE ELEMENT FAMILIES [PDF]

Genetics, 1986
ABSTRACT A quantitative model is proposed for the expected degree of relationship between copies of a family of transposable elements in a finite population of hosts. Special cases of the model (in which the process of homogenization of element copies either is or is not limited by transposition rate) are presented and illustrated, using
openaire   +2 more sources

Zisupton--A Novel Superfamily of DNA Transposable Elements Recently Active in Fish [PDF]

Molecular Biology and Evolution, 2011
Transposable elements are widespread mobile DNA sequences able to integrate into new locations within genomes. Through transposition and recombination, they significantly contribute to genome plasticity and evolution. They can also regulate gene expression and provide regulatory and coding sequences (CDSs) for the evolution of novel gene functions.
Boehne, Astrid, Zhou, Qingchun, Darras, Amandine, Schmidt, Cornelia, Schartl, Manfred, Galiana-Arnoux, Delphine, Volff, Jean-Nicolas   +6 more
openaire   +4 more sources