Results 231 to 240 of about 2,477,957 (291)

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Effect of Self-Sampling HPV DNA Testing on Cervical Cancer Screening in Singapore's Primary Care: Pragmatic Randomized Controlled Trial. [PDF]

Ann Fam Med
Ng XR, Quek IP, Pereira MJ, Molina JA, Tan KE, Ngeow J, Wong SKW.   +6 more
europepmc   +1 more source

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

Tunable Lipid Coatings Enable Cytoplasmic siRNA Delivery by DNA Origami. [PDF]

ACS Appl Mater Interfaces
Hendrickx PBM, des Rieux A, Bastings MMC.   +2 more
europepmc   +1 more source

A nucleic acid labeling chemistry reveals surface DNA on exosomes. [PDF]

Proc Natl Acad Sci U S A
Bošković F, Dutta Gupta P, Zhang J, Krishnan Y, Szostak JW.   +4 more
europepmc   +1 more source

Metal-Phenolic Coatings Enable Universal Design of Spherical Nucleic Acids. [PDF]

Angew Chem Int Ed Engl
Chen C, Luo T, Zhang Y, Liu X, Zhang H, Mirkin CA.   +5 more
europepmc   +1 more source

Actuation of CRP activating region 3 by formylation modulates the <i>Vibrio cholerae</i> response to oxidative DNA damage. [PDF]

Proc Natl Acad Sci U S A
Santos RERS, Basu P, O'Hara BJ, Gibson JA, Gebhardt MJ, Akut C, Robins WP, Mekalanos JJ, Dove SL, Watnick PI.   +9 more
europepmc   +1 more source

Correction for Zhang et al., Programmable DNA hydrogels for dual-mode PD-L1 suppression via polyvalent LYTAC mimics and transcriptional silencing. [PDF]

Proc Natl Acad Sci U S A
europepmc   +1 more source

Department of Health and Human Services Recombinant DNA Advisory Committee National Institutes of Health - Minutes of Meeting - September 12, 1997

, 1998
Recombinant DNA Advisory Committee
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