Results 91 to 100 of about 210,905 (300)
An interferon gamma-gp120 fusion delivered as a DNA vaccine induces enhanced priming
, 2005 Nucleic acid vaccination has many potential advantages over traditional methods, but suffers from the fact that DNA vaccines tend to be relatively poorly immunogenic.
Heath, A.W. +3 more
core +1 more source
Advanced Science, EarlyView.A senolytic sonovaccine platform (SenoVac) is developed, in which senescent cell‐derived vesicles serve as broad senescent cell antigen reservior. The “2‐step” click chemistry strategy for effective lymph node delivery, and ultrasound‐triggered endosomal escape to boost cross‐presentation, ensures efficient senescent cell clearance and disease ...
Liang Zhang +10 more
wiley +1 more source
Production of EV71 vaccine candidates
, 2012 [[abstract]]Enterovirus 71 (EV71) is now recognized as an emerging neurotropic virus in Asia and with Coxsackie virus (CV) it is the other major causative agent of hand-foot-mouth diseases (HFMD).
Chong, P;Hsieh, SY;Liu, CC;Chou, AH;Yuan, CJ;Wu, SC;Liu, SJ;Chow, YH;Su, IJ;Klein, M
core +1 more source
Advanced Science, EarlyView.Pseudorabies virus (PRV), an emerging zoonotic α‐herpesvirus, causes life‐threatening human encephalitis. We identified a broad‐spectrum neutralizing antibody 6F7 targeting PRV gD. It blocks gD‐Nectin‐1 binding and membrane fusion, inhibiting replication across all PRV variants, representing a promising candidate for anti‐PRV therapy.
Yue Sun +11 more
wiley +1 more source
Novel approaches to improve DNA vaccine efficacy through protein inhibitors and electroporation
, 2012 [[abstract]]DNA vaccine represents a novel means to stimulate immune response and has provided effective protective immunity in various animals. However, the magnitude of the immune responses induced by DNA immunization varies to a great extent.
Huang, Li-Pu; Yang, Wen-Jen
core
Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects
Advanced Science, EarlyView.Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu +6 more
wiley +1 more source
OncoImmunology, 2018 Background. Sipuleucel T, an autologous cell-based vaccine targeting prostatic acid phosphatase (PAP), has demonstrated efficacy for the treatment of advanced prostate cancer.
Laura E. Johnson +6 more
doaj +1 more source
Immunisation of the somatostatin gene alters hypothalamic-pituitary-liver gene expressions and enhances growth in Dazu black goats [PDF]
Animal BioscienceObjective Somatostatin (SS) plays important regulatory roles in animal growth and reproduction by affecting the synthesis and secretion of growth hormone (GH). However, the mechanism by which SS regulates growth and development in goats is still unclear.
Ge Qin +6 more
doaj +1 more source
Breaking the DNA-vaccine bottleneck
, 2011 Monash University in Australia has developed a new approach towards DNA vaccine development that has the potential to cut the time it takes to produce a vaccine from up to nine months to four weeks or less.
Forde, G. +2 more
core
Advanced Science, EarlyView.Radiotherapy‐treated tumor membranes are integrated with Mn‐MOF nanoadjuvants to generate Mn@RM, a lymph node‐draining nanovaccine that delivers radiotherapy‐remodeled antigenic components. Mn@RM enhances dendritic cell activation, amplifies T cell‐mediated antitumor immunity, and synergizes with radiotherapy and PD‐1 blockade for combination cancer ...
Yiyu Wang +8 more
wiley +1 more source