Results 101 to 110 of about 210,905 (300)

COMPREHENSIVE REVIEW ON THE PROSPECTS AND CONUNDRUMS OF ANCIENT TO CONTEMPORARY MODERN IMMUNO-MODULATION TECHNIQUES PRACTICED IN HUMAN AND ANIMAL HEALTHCARE [PDF]

Exploratory Animal and Medical Research
Prevention of diseases by modifying the body’s immune system is considered the most important aspect of healthcare from a very early stage of human civilization.
Shibabrata Pattanayak
doaj   +1 more source

Immunogenicity and Potective Efficacy of DNA Vaccination against Actinobacillus pleuropneumoniae Serotype 1 in Mice

, 2012
[[abstract]]Actinobacillus pleuropneumoniae can induce haemorrhagic, fibrinous and necrotic pleuropneumonia in pigs that causes critical economic losses in swine industry. A number of virulence factors have been identified in A.
Chiang, Chung-Hao; Huang, Li-Pu; Yeh, Chien-Ju; Yang, Wen-Jen
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The chemotherapeutic agent DMXAA as a unique IRF3-dependent type-2 vaccine adjuvant [PDF]

, 2013
5,6-Dimethylxanthenone-4-acetic acid (DMXAA), a potent type I interferon (IFN) inducer, was evaluated as a chemotherapeutic agent in mouse cancer models and proved to be well tolerated in human cancer clinical trials.
Cevayir Coban, Kenji Mizuguchi, Junichi Ito, Etsushi Kuroda, Coban, C, Ishii, KJ, Choon Kit Tang, Shizuo Akira, Jounai, N, Benoit H Dessailly, Ito, J, Keiichi Ohata, Tang, CK, Akira, S, Mizuguchi, K, Ken J Ishii, Kouji Kobiyama, Ohata, K, Nao Jounai, Kuroda, E, Kobiyama, K, Dessailly, BH, Aoshi, T, Taiki Aoshi   +23 more
core   +1 more source

ProSiteHunter: A Unified Framework for Sequence‐Based Prediction of Protein‐Nucleic Acid and Protein‐Protein Binding Sites

Advanced Science, EarlyView.
This study proposed a unified sequence‐based framework for protein binding site prediction, which adopted a tri‐track semantic multi‐source feature fusion strategy to effectively capture diverse macromolecular interaction sites and further improved the accuracy of antibody‐antigen interaction prediction.
Dongliang Hou, Qihang Zhen, Zexin Lv, Xinyue Cui, Suhui Wang, Minghua Hou, Zhan Zhou, Xiaogen Zhou, Guijun Zhang   +8 more
wiley   +1 more source

Intradermal immunization with botulinum neurotoxin serotype E DNA vaccine induces humoral and cellular immunity and protects against lethal toxin challenge

Human Vaccines & Immunotherapeutics, 2019
Botulinum neurotoxins (BoNTs) produced by the spore-forming, gram-positive, anaerobic bacterium Clostridium botulinum are the most toxic substances known and cause botulism, flaccid paralysis, or death. Owing to their high lethality, BoNTs are classified
Na Young Kim, Hye Bin Ahn, Chi Ho Yu, Dong Hyun Song, Gyeung Haeng Hur, Young Kee Shin, Sungho Shin   +6 more
doaj   +1 more source

Intra-epithelial vaccination with COPV L1 DNA by particle-mediated DNA delivery protects against mucosal challenge with infectious COPV in beagle dogs.

, 2001
Protection against viral challenge with canine oral papillomavirus (COPV) was achieved by immunisation via particle-mediated DNA delivery (PMDD) of a plasmid encoding the COPV L1 gene to cutaneous and oral mucosal sites in beagle dogs.
Walcott, S., Nicholls, P.K., Thomsen, L., Stanley, M.A., Santos, E.B., Moore, R.A., Parry, N., Gough, G.   +7 more
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Immunogenicity of an HPV-16 L2 DNA vaccine

, 2009
The ability to elicit cross-neutralizing antibodies makes human papillomavirus (HPV) L2 capsid protein a possible HPV vaccine. We examined and compared the humoral response of mice immunized with a HPV-16 L2 DNA vaccine or with HPV-16 L2 protein.
Hitzeroth, I. I., Shephard, E., Kast, W. M., Müller, M., Stewart, D., Passmore, J. A. S., Rybicki, E. P., Williamson, A. L.   +7 more
core   +1 more source

Multiple Colonization with S. pneumoniae before and after Introduction of the Seven-Valent Conjugated Pneumococcal Polysaccharide Vaccine [PDF]

, 2010
Background: Simultaneous carriage of more than one strain of Streptococcus pneumoniae promotes horizontal gene transfer events and may lead to capsule switch and acquisition of antibiotic resistance. We studied the epidemiology of cocolonization with S.
Hinds Jason, Brugger, Silvio D., Frey, Pascal, Hinds, Jason, Brugger Silvio D., Frey Pascal, Silvio D Brugger, Silvio D. Brugger, Hinds, J, Brugger, SD, Aebi, S, Jason Hinds, Kathrin Mühlemann, Mühlemann, K, Suzanne Aebi, Mühlemann Kathrin, Aebi Suzanne, Aebi, Suzanne, Mühlemann, Kathrin, Pascal Frey, Frey, P   +20 more
core   +1 more source

Conformational Snapshots of CydDC in a Native Lipid Bilayer Coupling Heme Transport to Antibiotic Resistance

Advanced Science, EarlyView.
Phylogenetic and biochemical analyses of the heme transporter CydDC reveal its functional conservation throughout bacterial evolution and demonstrate its unique asymmetric allosteric mechanism. Furthermore, impairment of CydDC function directly affects bacterial antibiotic resistance and likely compromises antibiotic efficacy through drug efflux.
Lili Yang, Changbin Zhang, Mengyuan Lyu, Yongbo Luo, Jierou Zhang, Yujiao Chen, Lintao Luo, Wen Qiao, Xiangyangpeng Li, Yu Zhou, Zhongling Wei, Yuling Xiao, Qian Niu, Juan Zhou, Guanglin He, Binwu Ying, Zhaoming Su, Hao Chen, Xiaodi Tang, Haohao Dong   +19 more
wiley   +1 more source

Development and evaluation of DNA vaccines in chickens against a wild bird H6N2 avian influenza virus from Western Australia

, 2010
Genetic immunization, also known as DNA or polynucleotide immunisation, is well documented to induce broad-based immunity in various animal models of infectious and non-infectious diseases.
Shan, Songhua
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