Results 101 to 110 of about 1,964,734 (294)

From genomes to vaccines: Leishmania as a model:Leishmania as a model [PDF]

, 2002
The 35 Mb genome of Leishmania should be sequenced by late 2002. It contains approximately 8500 genes that will probably translate into more than 10 000 proteins.
Vilo, Jaak, Freeman, Tom, Lange, Uta, Vetrie, David, Blackwell, Jenefer M., Almeida, Renata, Ivens, Alasdair, Levick, Mark, Stober, Carmel, Blackwell, Jenefer M, Norrish, Alan, McCann, Sharon   +11 more
core   +1 more source

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31

Advanced Science, EarlyView.
Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou, Fangfang Han, Anqi Liu, Yang Yu, Rui Zhao, Zhengting Shi, Yanrong Lv, Jinli Liu, Shaopo Zu, Zhanyong Wei, Jin Yuan, Hui Hu   +11 more
wiley   +1 more source

COMPREHENSIVE REVIEW ON THE PROSPECTS AND CONUNDRUMS OF ANCIENT TO CONTEMPORARY MODERN IMMUNO-MODULATION TECHNIQUES PRACTICED IN HUMAN AND ANIMAL HEALTHCARE [PDF]

Exploratory Animal and Medical Research
Prevention of diseases by modifying the body’s immune system is considered the most important aspect of healthcare from a very early stage of human civilization.
Shibabrata Pattanayak
doaj   +1 more source

Breaking the DNA-vaccine bottleneck

, 2011
Monash University in Australia has developed a new approach towards DNA vaccine development that has the potential to cut the time it takes to produce a vaccine from up to nine months to four weeks or less.
Forde, G., Danquah, Michael, Forde, Gareth   +2 more
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A Spatially Directed Microneedle Patch Enables Intratumoral Co‐Delivery of FOLFIRINOX, Surufatinib, and Anti‐PD‐1 for Chemo‐Immunotherapy of Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
A double‐layered shell‐core microneedle patch is developed to co‐deliver FOLFIRINOX, surufatinib, and anti‐PD‐1 for localized chemo‐immunotherapy of PDAC. This strategy achieves sustained tumor suppression, reduces metastasis, and reprograms the TME by enhancing CD8+ T‐cell infiltration and inhibiting Tregs and M2 macrophages infiltration, while ...
Tingting Kong, Ximo Xu, Xiao Zhang, Chuntao Wu, Zhengjun Qiu, Beiyuan Hu, Zihao Qi, Qiang Tian, Yuqin Yang, Hanguang Dong, Fei Wu, Tuo Jin, Yan Zheng, Jiang Long   +13 more
wiley   +1 more source

Intradermal immunization with botulinum neurotoxin serotype E DNA vaccine induces humoral and cellular immunity and protects against lethal toxin challenge

Human Vaccines & Immunotherapeutics, 2019
Botulinum neurotoxins (BoNTs) produced by the spore-forming, gram-positive, anaerobic bacterium Clostridium botulinum are the most toxic substances known and cause botulism, flaccid paralysis, or death. Owing to their high lethality, BoNTs are classified
Na Young Kim, Hye Bin Ahn, Chi Ho Yu, Dong Hyun Song, Gyeung Haeng Hur, Young Kee Shin, Sungho Shin   +6 more
doaj   +1 more source

Immune-enhancing effects of Taishan Pinus massoniana pollen polysaccharides on DNA vaccine expressing Bordetella avium ompA

Frontiers in Microbiology, 2016
Bordetella avium is the causative agent of bordetellosis, which remains to be the cause of severe losses in the turkey industry. Given the lack of vaccines that can provide good protection, developing a novel vaccine against B. avium infection is crucial.
Fujie eZhu, Xiao eLiu, Zhenhong eSun, Cuilian eYu, Liping eLiu, Shifa eYang, Bing eLi, Kai eWei, Ruiliang eZhu   +8 more
doaj   +1 more source

Somatic Evolution of a Germline Antibody Expands its Breadth to Neutralize Early SARS‐CoV‐2 Omicron Variants

Advanced Science, EarlyView.
Engineering of the 148‐germline (148‐GL) antibody reveals a roadmap for overcoming SARS‐CoV‐2 viral escape. By introducing four specific somatic hypermutations, the resulting 148‐M4 variant restores potent neutralization against Omicron BA.1 and BA.4/5.
Huibin Lv, Ziqi Feng, Qi Wen Teo, Chunke Chen, Akshita B. Gopal, Danbi Choi, Timothy J. C. Tan, Yun Sang Tang, Lewis Siu, Armita Nourmohammad, Roberto Bruzzone, Ian A. Wilson, Meng Yuan, Nicholas C. Wu, Chris K. P. Mok   +14 more
wiley   +1 more source

Malaria immunology and vaccine development

, 2008
This thesis describes work undertaken by the author at the University of Oxford. Itbegins by providing an introduction to malaria infection and pathophysiology, anda review of the latest attempts to produce an effective malaria vaccine.
Thompson, Fiona Mary
core   +1 more source

Immunogenicity and Potective Efficacy of DNA Vaccination against Actinobacillus pleuropneumoniae Serotype 1 in Mice

, 2012
[[abstract]]Actinobacillus pleuropneumoniae can induce haemorrhagic, fibrinous and necrotic pleuropneumonia in pigs that causes critical economic losses in swine industry. A number of virulence factors have been identified in A.
Chiang, Chung-Hao; Huang, Li-Pu; Yeh, Chien-Ju; Yang, Wen-Jen
core