Results 241 to 250 of about 1,964,734 (294)

Engineering mRNA‐LNP Medicines for the Ageing Brain: Opportunities and Challenges for Neurodegenerative Diseases

Exploration, EarlyView.
This review highlights recent advances in engineering messenger RNA (mRNA)‐lipid nanoparticles (LNPs) to cross the ageing blood–brain barrier and target neurodegenerative diseases. It outlines design principles, delivery routes, and translational challenges, charting a roadmap towards clinical application of mRNA‐LNP therapeutics for neurodegenerative ...
Abdel Ali Belaidi, Denzil L. Furtado, Francesca Alves, Rebecca M. Nisbet, Scott Ayton, Ashley I. Bush   +5 more
wiley   +1 more source

DNA vaccine targeting betacoronavirus spike protein blocks neuroinvasion and neuroinflammation in swine via dual antiviral-immunomodulatory action. [PDF]

NPJ Vaccines
Yu H, Shi J, Fu G, Cao Z, Qiu R, Zhao T, Zhang J, Lan Y, Guan J, Zhao K, Gao F, He W, Li Z.   +12 more
europepmc   +1 more source

Illuminating point‐of‐care diagnostics with aggregation‐induced emission biosensors

FlexMat, EarlyView.
This review highlights the application of aggregation‐induced emission luminogens (AIEgens) in point‐of‐care (POC) diagnostics for disease biomarker detection. It systematically examines a range of biosensing platforms, including lateral flow immunoassays, microfluidic chips, and electrochemiluminescence sensors, alongside their utility in detecting ...
Danni Hu, Yubing Hu, Dong Wang, Ben Zhong Tang   +3 more
wiley   +1 more source

Safety and Immunogenicity of a Canine Distemper DNA Vaccine Formulated with Lipid Nanoparticles in Dogs, Foxes, and Raccoon Dogs. [PDF]

Vaccines (Basel)
Huo H, Wang H, Liang S, Wang Z, Wang J, Wang Q, Li C, Tao Y, Ge J, Wen Z, Wang J, Chen W, Wang X, Shuai L, Bu Z.   +14 more
europepmc   +1 more source

Ferritin-Based HA DNA Vaccine Outperforms Conventional Designs in Inducing Protective Immunity Against Seasonal Influenza. [PDF]

Vaccines (Basel)
Lin H, Jiang Y, Li Y, Zhong Y, Chen M, Jiang W, Xiang R, Cao N, Sun L, Wang X, Lu L, Wang Q, Han G, Ma D, Wang B.   +14 more
europepmc   +1 more source

Intramuscular DNA vaccine provides protection in non-human primate and mouse models of SARS-CoV-2. [PDF]

Front Immunol
Sood S, Gary EN, Matar M, Kim J, Hojecki CE, Warner B, Vendramelli R, Truong T, Smith A, Rice J, Sparks J, DeSalvo M, Henderson J, Rogers JA, Sharma A, Pessaint L, Iavarone CA, Kobasa D, Boyer JD, Lindborg S, Anwer K.   +20 more
europepmc   +1 more source

Enhanced HIV immune responses elicited by an apoptotic single-cycle SHIV lentivector DNA vaccine. [PDF]

Front Cell Infect Microbiol
Bose D, Rogers KA, Shirreff LM, Chebloune Y, Villinger FJ.   +4 more
europepmc   +1 more source

Assessment of Immunogenicity of Multi-Epitope DNA Vaccine Encoding CDPK3, ROP22 & MIC8 of <i>Toxoplasma gondii</i> Adjuvanted with IL-12 against Acute and Chronic Toxoplasmosis in BALB/c Mice. [PDF]

Iran J Parasitol
Abasi E, Khademvatan S, Shojaee S, Mohebali M, Foroutan M, Zeraati H, Keshavarz Valian H.   +6 more
europepmc   +1 more source

Development and evaluation of protective immunity of a ROP27 DNA vaccine against Eimeria tenella in chickens. [PDF]

Poult Sci
Zhao W, Niu Z, Liu K, Zhang X, Kang S, Dou K, Zhao J, Bai R, Zheng M, Lv X.   +9 more
europepmc   +1 more source

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DNA vaccines

Current Opinion in Immunology, 1996
Preclinical DNA vaccine development has continued apace during the past year, with the investigation of several new infectious and non-infectious disease targets as well as advances in our understanding of some of the basic immunologic mechanisms, such as effector cells, responsible for conferring protection.
J B, Ulmer, J C, Sadoff, M A, Liu
  +11 more sources