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DNA Vaccines and Intradermal Vaccination by DNA Tattooing
2010Over the past two decades, DNA vaccination has been developed as a method for the induction of immune responses. However, in spite of high expectations based on their efficacy in preclinical models, immunogenicity of first generation DNA vaccines in clinical trials was shown to be poor, and no DNA vaccines have yet been licensed for human use.
K, Oosterhuis +3 more
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1999
Therapeutic and prophylactic DNA vaccine clinical trials for a variety of pathogens and cancers are underway (Chattergoon et al., 1997; Taubes, 1997). The speed with which initiation of these trials occurred is no less than astounding; clinical trials for a human immunodeficiency virus (HIV) gp160 DNA-based vaccine were underway within 36 months of the
P J, Lewis, L A, Babiuk
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Therapeutic and prophylactic DNA vaccine clinical trials for a variety of pathogens and cancers are underway (Chattergoon et al., 1997; Taubes, 1997). The speed with which initiation of these trials occurred is no less than astounding; clinical trials for a human immunodeficiency virus (HIV) gp160 DNA-based vaccine were underway within 36 months of the
P J, Lewis, L A, Babiuk
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Current Drug Targets - Immune, Endocrine & Metabolic Disorders, 2001
Genes that code for the production of protein antigens have been cloned and recombined with plasmids. Gene-plasmid constructs have been amplified in a bacterial host, purified and administered to a mammalian host. The gene is expressed in the host and the antigen that is produced induces an immune response.
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Genes that code for the production of protein antigens have been cloned and recombined with plasmids. Gene-plasmid constructs have been amplified in a bacterial host, purified and administered to a mammalian host. The gene is expressed in the host and the antigen that is produced induces an immune response.
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Frontiers in Bioscience, 2006
DNA vaccines, also referred to as genetic, plasmid or polynucleotide vaccines, represent a relatively simple and economical method to exploit gene transfer for immunization against tumor associated antigens. This review discusses the potential advantages of DNA vaccines for cancer immunotherapy as compared to conventional protein vaccines and viral ...
Denise R, Shaw, Theresa V, Strong
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DNA vaccines, also referred to as genetic, plasmid or polynucleotide vaccines, represent a relatively simple and economical method to exploit gene transfer for immunization against tumor associated antigens. This review discusses the potential advantages of DNA vaccines for cancer immunotherapy as compared to conventional protein vaccines and viral ...
Denise R, Shaw, Theresa V, Strong
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2014
Multiple sclerosis (MS) is the most common inflammatory, demyelinating, and neurodegenerative disorder of the central nervous system (CNS) in humans. Although the etiology of MS remains unknown, several lines of evidence support the notion that autoimmunity against components of the myelin sheath plays a major role in susceptibility to and development ...
Nicolás, Fissolo +2 more
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Multiple sclerosis (MS) is the most common inflammatory, demyelinating, and neurodegenerative disorder of the central nervous system (CNS) in humans. Although the etiology of MS remains unknown, several lines of evidence support the notion that autoimmunity against components of the myelin sheath plays a major role in susceptibility to and development ...
Nicolás, Fissolo +2 more
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The regulation of DNA vaccines
Current Opinion in Biotechnology, 2001The framework for regulating DNA vaccines has been in place since the first clinical trial was initiated in the mid-1990s. American and European regulatory guidance has evolved on the basis of insights provided by ongoing preclinical and clinical studies.
H A, Smith, D M, Klinman
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International Journal of Technology Assessment in Health Care, 1994
AbstractIt has been 20 years since the concepts that are now embraced in the term recombinant DNA technology were first described. The technology has been used to design new vaccines, and one product — that for hepatitis B — has been in widespread use for almost a decade.
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AbstractIt has been 20 years since the concepts that are now embraced in the term recombinant DNA technology were first described. The technology has been used to design new vaccines, and one product — that for hepatitis B — has been in widespread use for almost a decade.
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2003
Vaccination has relied, in general, on two technologies for the production of antigenic material suitable for the generation of a protective immune response; live infectious agents and inactivated or subunit vaccine preparations. Live infectious agents generally are most efficacious, but there is always a risk factor when using this type of vaccine ...
S, van Drunen Littel-van den Hurk +2 more
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Vaccination has relied, in general, on two technologies for the production of antigenic material suitable for the generation of a protective immune response; live infectious agents and inactivated or subunit vaccine preparations. Live infectious agents generally are most efficacious, but there is always a risk factor when using this type of vaccine ...
S, van Drunen Littel-van den Hurk +2 more
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DNA vaccines for transplantation
Expert Opinion on Biological Therapy, 2010DNA vaccination for transplantation has been less investigated compared with DNA vaccines for infectious disease, cancer and pathological autoimmunity. However, the emerging role of transplant-induced autoimmunity in allograft rejection may lead to the development of new DNA vaccination approaches where peripheral delivery of an antigen shared by ...
Alice F, Li, Alan, Escher
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Vaccine, 2002
DNA vaccines have been the subjects of much effort over the past decade due to their ability to induce broad-based immune responses and protection in various animal models of infectious and non-infectious diseases. In particular, influenza DNA vaccines have been well studied.
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DNA vaccines have been the subjects of much effort over the past decade due to their ability to induce broad-based immune responses and protection in various animal models of infectious and non-infectious diseases. In particular, influenza DNA vaccines have been well studied.
openaire +2 more sources