Results 101 to 110 of about 171,936 (284)
, 2023 Toxoplasma gondii (T. gondii) has many intermediate hosts, obligately invades nucleated cells, and seriously threatens human and animal health due to a lack of effective drugs and vaccines.
Xiaohan Zhang +8 more
core +1 more source
Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects
Advanced Science, EarlyView.Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu +6 more
wiley +1 more source
DNA Vaccines for Emerging Infectious Diseases: What If?
Emerging Infectious Diseases, 1996 A novel and powerful method for vaccine research, colloquially known as DNA vaccines, involves the deliberate introduction into tissues of a DNA plasmid carrying an antigen-coding gene that transfects cells in vivo and results in an immune response.
Robert G. Whalen
doaj +1 more source
Progresses in DNA-based heterologous prime-boost immunization strategies
, 2020 Although recombinant DNA and recombinant viral vectors expressing HIV antigens have yielded positive outcomes in animal models, these vaccines have not been effectively translated to humans.
Jackson, Ronald +2 more
core +1 more source
Advanced Science, EarlyView.Radiotherapy‐treated tumor membranes are integrated with Mn‐MOF nanoadjuvants to generate Mn@RM, a lymph node‐draining nanovaccine that delivers radiotherapy‐remodeled antigenic components. Mn@RM enhances dendritic cell activation, amplifies T cell‐mediated antitumor immunity, and synergizes with radiotherapy and PD‐1 blockade for combination cancer ...
Yiyu Wang +8 more
wiley +1 more source
Trial watch: DNA-based vaccines for oncological indications
OncoImmunology, 2017 DNA-based vaccination is a promising approach to cancer immunotherapy. DNA-based vaccines specific for tumor-associated antigens (TAAs) are indeed relatively simple to produce, cost-efficient and well tolerated.
Stefano Pierini +7 more
doaj +1 more source
Background: Influenza remains a persistent public health challenge due to antigenic drift and shift, necessitating vaccines capable of eliciting broad and durable immunity. Hemagglutinin (HA) antigen serves as the critical target for eliciting protective
Bin Wang +14 more
core +1 more source
A cGAS-Independent STING/IRF7 Pathway Mediates the Immunogenicity of DNA Vaccines
, 2016 It has been known since the discovery of DNA vaccines > 20 y ago that DNA vaccines can function as adjuvants. Our recent study reported the involvement of Aim2 as the sensor of DNA vaccines in eliciting Ag-specific Ab responses.
Wang, Shixia +3 more
core +1 more source
Advanced Science, EarlyView.This study proposed a unified sequence‐based framework for protein binding site prediction, which adopted a tri‐track semantic multi‐source feature fusion strategy to effectively capture diverse macromolecular interaction sites and further improved the accuracy of antibody‐antigen interaction prediction.
Dongliang Hou +8 more
wiley +1 more source
, 2012 [[abstract]]Actinobacillus pleuropneumoniae can induce haemorrhagic, fibrinous and necrotic pleuropneumonia in pigs that causes critical economic losses in swine industry. A number of virulence factors have been identified in A.
Chiang, Chung-Hao; Huang, Li-Pu; Yeh, Chien-Ju; Yang, Wen-Jen
core