Results 101 to 110 of about 1,806,959 (282)
DNA Vaccines for Emerging Infectious Diseases: What If?
Emerging Infectious Diseases, 1996 A novel and powerful method for vaccine research, colloquially known as DNA vaccines, involves the deliberate introduction into tissues of a DNA plasmid carrying an antigen-coding gene that transfects cells in vivo and results in an immune response.
Robert G. Whalen
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Immunogenicity of DNA vaccines in humans: It takes two to tango
, 2008 Two recently completed phase I clinical trials with candidate HIV-1 vaccines demonstrated that DNA vaccines are, indeed, immunogenic in humans, even when administered through routine needle injections.
Shan Lu, Lu, Shan
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Advanced Science, EarlyView.Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon +27 more
wiley +1 more source
Trial watch: DNA-based vaccines for oncological indications
OncoImmunology, 2017 DNA-based vaccination is a promising approach to cancer immunotherapy. DNA-based vaccines specific for tumor-associated antigens (TAAs) are indeed relatively simple to produce, cost-efficient and well tolerated.
Stefano Pierini +7 more
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In vitro transcribed RNA-based platform vaccines : past, present, and future
, 2023 mRNA was discovered in 1961, but it was not used as a vaccine until after three decades. Recently, the development of mRNA vaccine technology gained great impetus from the pursuit of vaccines against COVID-19.
Perenkov, Alexey D. +7 more
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Advanced Science, EarlyView.ADORA2A activation suppresses NFκB‐dependent CCL5 production in cNK cells during chronic HBV infection, disrupting intrahepatic DC recruitment and HBV‐specific CD8+ T‐cell differentiation and function. Targeting the ADORA2A/NFκB/CCL5 axis restores antiviral immunity and facilitates HBV clearance.
Ailu Yang +9 more
wiley +1 more source
The next-generation DNA vaccine platforms and delivery systems: advances, challenges and prospects
Frontiers in ImmunologyVaccines have proven effective in the treatment and prevention of numerous diseases. However, traditional attenuated and inactivated vaccines suffer from certain drawbacks such as complex preparation, limited efficacy, potential risks and others.
Bowen Lu +15 more
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Identification of Aim2 as a sensor for DNA vaccines
, 2015 Recent human study data have re-established the value of DNA vaccines, especially in priming high-level Ag-specific Ab responses, but also raised questions about the mechanisms responsible for such effects. Whereas previous reports have shown involvement
Wang, Shixia +3 more
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Advanced Science, EarlyView.MPXV infection leads to persistent viral replication and severe local inflammation, while existing treatments cannot simultaneously remove viruses and repair injured tissue. This study constructs Polymer@mPDA@Gel hydrogel via a two‐step hierarchical assembly method: mPDA anchors photothermal polymers to form antiviral photothermal subunits, which are ...
Ming Zhang +7 more
wiley +1 more source
, 2012 [[abstract]]Actinobacillus pleuropneumoniae can induce haemorrhagic, fibrinous and necrotic pleuropneumonia in pigs that causes critical economic losses in swine industry. A number of virulence factors have been identified in A.
Chiang, Chung-Hao; Huang, Li-Pu; Yeh, Chien-Ju; Yang, Wen-Jen
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