Results 241 to 250 of about 171,936 (284)

Degradable Nanocarriers Capable of Gene Delivery Derived from pH‐Responsive Polyester: RROP Copolymerization Between Cyclic Ketene Acetals

Macromolecular Rapid Communications, EarlyView.
Polyesters with inherent pH‐sensitivity are prepared through radical ring‐opening polymerization between cyclic ketene acetals. These polyesters demonstrate great potential as alternatives to conventional polycations for fabricating hybrid nanoparticles.
Yiyi Deng, Jonas Debbeler, Anja Traeger, Jens Gaitzsch   +3 more
wiley   +1 more source

Co-immunization with DNA vaccines encoding yidR and IL-17 augments host immune response against Klebsiella pneumoniae infection in mouse model. [PDF]

Virulence
Lv Z, Zhang X, Zhao K, Du L, Wang X, Chu Y, Huang T.   +6 more
europepmc   +1 more source

Humoral and Cellular Immune Responses Induced by Bivalent DNA Vaccines Expressing Fusion Capsid Proteins of Porcine Circovirus Genotypes 2a and 2b. [PDF]

Vaccines (Basel)
Meas S, Chaimongkolnukul K, Narkpuk J, Mekvichitsaeng P, Poomputsa K, Wanasen N, Roshorm YM.   +6 more
europepmc   +1 more source

DNA vaccines

Seminars in Immunology, 1997
DNA vaccines use eukaryotic expression vectors to produce immunizing proteins in the vaccinated host. Popular methods of delivery are intramuscular and intradermal saline injections of DNA and gene gun bombardment of skin with DNA-coated gold beads.
Harriet L Robinson
exaly   +12 more sources

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DNA Vaccines

New England Journal of Medicine, 1996
Immunization with plasmid DNA encoding antigenic proteins elicits both antibody and cell-mediated immune responses. This method of producing the protein antigens of interest directly in host cells can provide appropriate tertiary structure for the induction of conformationally specific antibodies, and also facilitates the induction of cellular immune ...
W M Mcdonnell
exaly   +11 more sources

DNA vaccines for biodefence

Advanced Drug Delivery Reviews, 2005
The advantages associated with DNA vaccines include the speed with which they may be constructed and produced at large-scale, the ability to produce a broad spectrum of immune responses, and the ability for delivery using non-invasive means. In addition, DNA vaccines may be manipulated to express multiple antigens and may be tailored for the induction ...
Helen S, Garmory, Stuart D, Perkins, Robert J, Phillpotts, Richard W, Titball   +3 more
openaire   +3 more sources

The regulation of DNA vaccines

Current Opinion in Biotechnology, 2001
The framework for regulating DNA vaccines has been in place since the first clinical trial was initiated in the mid-1990s. American and European regulatory guidance has evolved on the basis of insights provided by ongoing preclinical and clinical studies.
D M Klinman
exaly   +3 more sources

HPV DNA vaccines

Frontiers in Bioscience, 2003
Human papillomaviruses (HPV), particularly HPV type 16, are the primary etiologic agent of cervical cancer. Thus, HPV-associated cervical malignancies might be prevented or treated by induction of the appropriate virus-specific immune responses in patients.
Michelle, Moniz, Morris, Ling, Chien-Fu, Hung, T-C, Wu   +3 more
openaire   +2 more sources

DNA vaccination in the avian

Veterinary Immunology and Immunopathology, 2002
Inoculation of naked DNA represents a novel approach to vaccine and immune therapeutic development. DNA vaccines or genetic immunization offers several advantages over the conventional vaccines for specific immune activation. Although a large number of vaccines have been made and are being used in the poultry industry, there have been no major advances
G L, Oshop, S, Elankumaran, R A, Heckert
openaire   +2 more sources

DNA Vaccines and Intradermal Vaccination by DNA Tattooing

2010
Over the past two decades, DNA vaccination has been developed as a method for the induction of immune responses. However, in spite of high expectations based on their efficacy in preclinical models, immunogenicity of first generation DNA vaccines in clinical trials was shown to be poor, and no DNA vaccines have yet been licensed for human use.
K, Oosterhuis, J H, van den Berg, T N, Schumacher, J B A G, Haanen   +3 more
openaire   +2 more sources