Results 41 to 50 of about 3,025,811 (189)
Human Vaccines & Immunotherapeutics, 2017 We previously developed optimized DNA vaccines against both Lassa fever and Ebola hemorrhagic fever viruses and demonstrated that they were protective individually in guinea pig and nonhuman primate models.
Kathleen A. Cashman +8 more
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Have mRNA vaccines sentenced DNA vaccines to death?
Expert Review of Vaccines, 2023 Introduction After receiving emergency approval during the COVID-19 pandemic, mRNA vaccines have taken center stage in the quest to enhance future vaccination strategies for both infectious diseases and cancer.
Alberto Cagigi, Bruno Douradinha
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Human Vaccines & Immunotherapeutics, 2018 HIV-specific T-cell responses play a key role in controlling HIV infection, and therapeutic vaccines for HIV that aim to improve viral control will likely need to improve on the T-cell responses induced by infection.
Paul Munson +8 more
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A Review of DNA Vaccines Against Influenza
Frontiers in Immunology, 2018 The challenges of effective vaccination against influenza are gaining more mainstream attention, as recent influenza seasons have reported low efficacy in annual vaccination programs worldwide.
L. Lee, L. Izzard, A. Hurt
semanticscholar +1 more source
Therapeutic DNA Vaccines for Human Papillomavirus and Associated Diseases
Human Gene Therapy, 2018 Human papillomavirus (HPV) has long been recognized as the causative agent of cervical cancer. High-risk HPV types 16 and 18 alone are responsible for over 70% of all cases of cervical cancers.
Max A. Cheng +5 more
semanticscholar +1 more source
Tick-Tattoo: DNA Vaccination Against B. burgdorferi or Ixodes scapularis Tick Proteins
Frontiers in Immunology, 2021 IntroductionBorrelia burgdorferi sensu lato (sl) is the causative agent of Lyme borreliosis. Currently there is no human vaccine against Lyme borreliosis, and most research focuses on recombinant protein vaccines. DNA tattoo vaccination with B.
Michelle J. Klouwens +10 more
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Liposome‐mediated DNA vaccination [PDF]
FEBS Letters, 1997 Numerous reports have indicated that intramuscular injection of antigen‐coding naked plasmid DNA can trigger humoral and cell‐mediated protective immunity against infection. This follows DNA uptake by muscle fibres, leading to the expression and extracellular release of the antigen. Here it is shown for the first time that intramuscular immunization of
Gregoriadis, Gregory +2 more
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The Current State of Vaccine Development for Specific Prophylactics of Arenaviral Hemorrhagic Fevers
Проблемы особо опасных инфекций, 2018 Presently, the Arenavirus genus (Arenaviridae family) includes 26 individual species of viruses. It is divided into two main groups – Old World arenaviruses and New World arenaviruses.
T. E. Sizikova +3 more
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Human Vaccines & Immunotherapeutics, 2013 Since the introduction of DNA vaccines two decades ago, this attractive strategy has been hampered by its low immunogenicity in humans. Studies conducted to improve the immunogenicity of DNA vaccines have shown that understanding the mechanism of action of DNA vaccines might be the key to successfully improving their immunogenicity.
Coban, Cevayir +4 more
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Immunogenicity of Candidate MERS-CoV DNA Vaccines Based on the Spike Protein
Scientific Reports, 2017 MERS-coronavirus is a novel zoonotic pathogen which spread rapidly to >25 countries since 2012. Its apparent endemicity and the wide spread of its reservoir host (dromedary camels) in the Arabian Peninsula highlight the ongoing public health threat of ...
Sawsan S. Al-amri +9 more
semanticscholar +1 more source