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The Current State of Vaccine Development for Specific Prophylactics of Arenaviral Hemorrhagic Fevers
Проблемы особо опасных инфекций, 2018 Presently, the Arenavirus genus (Arenaviridae family) includes 26 individual species of viruses. It is divided into two main groups – Old World arenaviruses and New World arenaviruses.
T. E. Sizikova +3 more
doaj +1 more source
Expression of the murine cytomegalovirus glycoprotein H by recombinant vaccinia virus [PDF]
, 1994 The sequence of the gene encoding glycoprotein H (gH) of murine cytomegalovirus (MCMV) strain Smith was determined and compared with the sequence of the gH of MCMV strain K181. Transcriptional analysis showed that gH is encoded by a large mRNA of 5.0 kb,
Koszinowski, Ulrich H. +4 more
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Liposome‐mediated DNA vaccination [PDF]
FEBS Letters, 1997 Numerous reports have indicated that intramuscular injection of antigen‐coding naked plasmid DNA can trigger humoral and cell‐mediated protective immunity against infection. This follows DNA uptake by muscle fibres, leading to the expression and extracellular release of the antigen. Here it is shown for the first time that intramuscular immunization of
Gregoriadis, Gregory +2 more
openaire +2 more sources
Toward QbD Process Understanding on DNA Vaccine Purification Using Design of Experiment
Frontiers in Bioengineering and Biotechnology, 2021 DNA vaccines, the third generation of vaccines, are a promising therapeutic option for many diseases as they offer the customization of their ability on protection and treatment with high stability.
Lalintip Hocharoen +2 more
doaj +1 more source
Immunogenicity of Candidate MERS-CoV DNA Vaccines Based on the Spike Protein
Scientific Reports, 2017 MERS-coronavirus is a novel zoonotic pathogen which spread rapidly to >25 countries since 2012. Its apparent endemicity and the wide spread of its reservoir host (dromedary camels) in the Arabian Peninsula highlight the ongoing public health threat of ...
Sawsan S. Al-amri +9 more
semanticscholar +1 more source
Population, sexual and reproductive health, rights and sustainable development: forging a common agenda. [PDF]
, 2010 This article suggests that sexual and reproductive health and rights activists seeking to influence the post-2015 international development paradigm must work with sustainable development advocates concerned with a range of issues, including climate ...
Campbell, D. M. +11 more
core +1 more source
Human Vaccines & Immunotherapeutics, 2013 Since the introduction of DNA vaccines two decades ago, this attractive strategy has been hampered by its low immunogenicity in humans. Studies conducted to improve the immunogenicity of DNA vaccines have shown that understanding the mechanism of action of DNA vaccines might be the key to successfully improving their immunogenicity.
Coban, Cevayir +4 more
openaire +2 more sources
Therapeutic DNA Vaccines for Human Papillomavirus and Associated Diseases
Human Gene Therapy, 2018 Human papillomavirus (HPV) has long been recognized as the causative agent of cervical cancer. High-risk HPV types 16 and 18 alone are responsible for over 70% of all cases of cervical cancers.
Max A. Cheng +5 more
semanticscholar +1 more source
Accelerating vaccine development and deployment: report of a Royal Society satellite meeting. [PDF]
, 2011 The Royal Society convened a meeting on the 17th and 18th November 2010 to review the current ways in which vaccines are developed and deployed, and to make recommendations as to how each of these processes might be accelerated.
Bregu, Migena +3 more
core +2 more sources
Molecular Adjuvants for DNA Vaccines.
Current Issues in Molecular Biology, 2017 Poor immunogenicity remains the single biggest obstacle to human DNA vaccines achieving their potential. Strategies to improve DNA vaccine efficacy include codon optimization, transfection reagents, electroporation, vaccine adjuvants or combination with ...
Lei Li, N. Petrovsky
semanticscholar +1 more source