Results 111 to 120 of about 3,105,790 (256)

A randomised, double-blind, controlled vaccine efficacy trial of DNA/MVA ME-TRAP against malaria infection in Gambian adults. [PDF]

, 2004
BACKGROUND: Many malaria vaccines are currently in development, although very few have been evaluated for efficacy in the field. Plasmodium falciparum multiple epitope (ME)- thrombospondin-related adhesion protein (TRAP) candidate vaccines are designed ...
Greenwood, Brian M, Pauline Kaye, Hill Adrian S. V, Kaye, Pauline, Imoukhuede, Egeruan B, Vasee S Moorthy, Moorthy Vasee S, Egeruan B Imoukhuede, Kalifa Bojang, Milligan Paul, Gilbert, Sarah C, Pinder Margaret, Walraven, Gijs, Margaret Pinder (1712), Gijs Walraven, Adrian S V Hill, Hill, Adrian SV, Egeruan B Imoukhuede (57141), Brian M Greenwood (45474), Walraven Gijs, Bojang, Kalifa, Brian M Greenwood, Vasee S Moorthy (57140), Greenwood Brian M, Sarah C Gilbert, Kalifa Bojang (57143), Paul Milligan (57142), Pauline Kaye (57145), Gijs Walraven (18413), Moorthy, Vasee S, Gilbert Sarah C, Keating, Sheila, Sarah C Gilbert (57146), Paul Milligan, Sheila Keating (57144), Milligan, Paul, Adrian S. V Hill (57147), Bojang Kalifa, Kaye Pauline, Sheila Keating, Margaret Pinder, Keating Sheila, Pinder, Margaret, Imoukhuede Egeruan B   +43 more
core   +2 more sources

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Murine nasal-associated lymphoid tissue (NALT) harbors human alphaherpesvirus 1 (HSV-1) DNA during latency, and dexamethasone triggers viral replication

Journal of Virology
Human alphaherpesvirus 1 (HSV-1) acute infection causes conjunctivitis, encephalitis, genital lesions, and herpes esophagitis. Following acute infection, HSV-1 and other alpha-herpesvirinae subfamily members establish life-long latency in neurons within ...
Kelly S. Harrison, Shannon R. Cowan, Clinton Jones   +2 more
doaj   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

The Agrobacterium tumefaciens Ti Plasmid Virulence Gene virE2 Reduces Sri Lankan Cassava Mosaic Virus Infection in Transgenic Nicotiana benthamiana Plants

Viruses, 2015
Cassava mosaic disease is a major constraint to cassava cultivation worldwide. In India, the disease is caused by Indian cassava mosaic virus (ICMV) and Sri Lankan cassava mosaic virus (SLCMV).
Thulasi Raveendrannair Resmi, Thomas Hohn, Barbara Hohn, Karuppannan Veluthambi   +3 more
doaj   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

hnRNPA2B1 recognizes RNA virus SFTSV infection through mitochondrial DNA

mBio
The heterogeneous nuclear ribonucleoprotein (hnRNPA2B1, hereafter A2B1) was identified as a novel nuclear DNA sensor that mediates antiviral immunity by recognizing viral DNA in the nucleus. However, it remains largely unclear whether A2B1 could function
Xin-bo Huang, Yue Zhang, Jing-wen Fan, Xin-yu Yu, Yun-lan Fang, Jin-xin Ren, Bin-yan Liu   +6 more
doaj   +1 more source

A mechanism for the inhibition of DNA-PK-mediated DNA sensing by a virus.

PLoS Pathogens, 2013
The innate immune system is critical in the response to infection by pathogens and it is activated by pattern recognition receptors (PRRs) binding to pathogen associated molecular patterns (PAMPs).
Nicholas E Peters, Nicholas E Peters, Brian J Ferguson, Michela Mazzon, Aodhnait S Fahy, Ewelina Krysztofinska, Raquel Arribas-Bosacoma, Laurence H Pearl, Hongwei Ren, Geoffrey L Smith   +9 more
doaj   +1 more source