Results 171 to 180 of about 617,524 (203)
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Unstable DNA synthesized by polyoma virus-infected cells
Virology, 1966Confluent mouse embryo monolayer cultures are induced by infection with polyoma virus to synthesize DNA which behaves on columns of methylated albumin and upon band centrifugation like cellular DNA. “Pulse-chase” experiments revealed that this DNA, in contrast to normal cellular DNA, is degraded in the infected cultures to a molecular weight ...
T, Ben-Porat, C, Coto, A S, Kaplan
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Polysomes and Protein Synthesis in Cells Infected with a DNA Virus
Science, 1966In HEp-2 cells infected with herpes simplex virus the rate of protein synthesis at first decline, is stimulated between 4 and 8 hours after infection, and progressively and irreversibly declines from 9 to 16 hours later. The increase and decrease in rates coincide with corresponding changes in the amounts of cytoplasmic polysomes and amounts of labeled
R J, Sydiskis, B, Roizman
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Infectivities of native and cloned DNA of cauliflower mosaic virus
Gene, 1980Infectivity assays on turnips reveal that (i) cauliflower mosaic virus (CaMV) DNA, whether circular or linear, is as infectious as the complete virus; (ii) linear DNA obtained with restriction enzymes from the native CaMV DNA has the same specific infectivity as when first cloned in plasmid (pBR322) or bacteriophage (lambda gtWES) vectors and then ...
G, Lebeurier, L, Hirth, T, Hohn, B, Hohn
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RNA recognition by PKR during DNA virus infection
Journal of Medical VirologyAbstract Protein kinase R (PKR) is a double‐stranded RNA (dsRNA) binding protein that plays a crucial role in innate immunity during viral infection and can restrict both DNA and RNA viruses. The potency of its antiviral function is further reflected by the large number of viral‐encoded PKR antagonists.
Ruilin, Zhang, John, Karijolich
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Mitochondrial DNA Role in Zika Virus Infection
2022Zika virus (ZIKV) is a member of the Flavivirus family. ZIKV infection ranges from asymptomatic to a mild disease in adults. However, in 2015, ZIKV infection became a public health emergency in the Americas associated with neurological alterations such as Guillain-Barré syndrome (GBS) in adults and congenital zika syndrome (CZS). By blocking type I IFN
Fabiana Rabe Carvalho +2 more
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Negatively supercoiled DNA from plants infected with a single-stranded DNA virus
Biochemical and Biophysical Research Communications, 1984A method for isolating covalently closed circular double-stranded DNA from plants infected with the geminivirus, tomato golden mosaic virus, is described. Ethidium bromide titration showed this DNA to be negatively supercoiled with a superhelical density of -0.062.
G, Sunter, R H, Coutts, K W, Buck
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Prevalence and Persistence of TT Virus DNA in HIV1-Infected Individuals
Infection, 2003TT virus (TTV) is a recently discovered virus with a high DNA prevalence in different populations. Its role in pathogenesis is uncertain, particularly in immunocompromised patients.Prevalence of TTV-DNA was evaluated in a cohort of HIV-infected patients and in blood donors by nested PCR, using two different primer sets: T primers, derived from the open
D, Rey +5 more
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Analysis of transcriptional control in DNA virus infections
1999Abstract Transcriptional control in DNA viruses is highly regulated, showing a high degree of both tissue-specificity and temporal control of gene expression. During the replication of DNA viruses, transcription occurs first from the immediate-early (if applicable) and early genes, followed by the late genes, with these two phases of ...
S K Thomas, D S Latchman
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A DNA vaccine for the prevention of Ebola virus infection.
Current opinion in molecular therapeutics, 2008The NIH and Vical Inc are developing an intramuscular needle-free DNA vaccine containing plasmids encoding the envelope glycoprotein of Ebola virus (EBOV) from the Sudan and Zaire strains, and the nucleoprotein of EBOV Zaire strain. A phase I clinical trial demonstrated a good safety profile, with most adverse events limited to the site of injection ...
Markalain, Dery, Daniel G, Bausch
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Diagnosis of pseudorabies virus infection in pigs with specific dna probes
Research in Veterinary Science, 1987Two DNA probes directed against pseudorabies virus DNA were developed for use in a dot hybridisation to detect the presence of pseudorabies virus in infected tissues. The specificity of the probes and their sensitivity were analysed. There was a strong correlation between the results obtained by dot hybridisation and those obtained by conventional ...
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