Results 221 to 230 of about 431,774 (259)

DNA-PK senses DNA virus infection in human cells

The Journal of Immunology, 2021
Abstract The type I interferon (IFN-I) response to virus infection is initiated by the detection of nucleic acids by intracellular pattern recognition receptors (PRRs). The sensing of DNA viruses by PRRs is carried out by a number of DNA-binding PRRs that signal via the adaptor protein stimulator of interferon genes (STING) to drive IFN ...
Brian J Ferguson, Dayana Hristova, Marisa Oliveira, Emma Wagner   +3 more
openaire   +1 more source

Chemotherapy of DNA virus infections

1999
Abstract In recent years there have been considerable advances in the development of effective antiviral drugs. Much of this progress has been driven by the need to combat human immunodeficiency virus (HIV) infection, but there are currently nearly thirty antiviral agents in clinical development or licensed for use in humans against ...
Patricia A Cane, Deenan Pillay
openaire   +1 more source

Synthesis of DNA and Protein in Cells infected with Vaccinia Virus

Nature, 1966
THE study of DNA and protein synthesis in cells infected with vaccinia virus has previously led to contradictory results. Both increase1,2 and decrease3–5 of DNA and protein synthesis have been demonstrated. This may be due to the use of different cell strains and stages of virus infection.
V M, Zhdanov, I A, Kozlova, L A, Melnikova, O P, Peterson   +3 more
openaire   +2 more sources

Virus DNA and host DNA in polyoma virus-infected cells at high temperature

Virology, 1972
Abstract Incubation of mouse kidney (MK) cells at 41.6 ± 0.1° led to a rapid inhibition of DNA synthesis. Infection with the SP 2 mutant of polyoma virus (PV) at 41.6° induced the cells to synthesize DNA again. However, production of infectious SP 2 DNA or infectious virions was reduced under these conditions.
openaire   +2 more sources

Control of DNA synthesis in cells infected with polyoma virus

Virology, 1968
Abstract It had previously been established that cell DNA synthesis is inhibited in growing mouse embryo cells productively infected at high multiplicity with polyoma TSP1. In the present study it was found that cell DNA was stimulated in the same cell-virus system, but infected at low multiplicity ( Branton and Sheinin, 1968 ).
P E, Branton, R, Sheinin
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DNA vaccination against respiratory influenza virus infection

Vaccine, 2001
DNA vaccination using plasmid encoding the hemagglutinin (HA) gene of influenza A/PR/8/34 virus to induce long-lasting protective immunity against respiratory infection was evaluated in this study. Using liposomes as carriers, the efficacy of DNA vaccines was determined using a lethal influenza infection model in mice.
J P, Wong, M A, Zabielski, F L, Schmaltz, G G, Brownlee, L A, Bussey, K, Marshall, T, Borralho, L P, Nagata   +7 more
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Polysomes and Protein Synthesis in Cells Infected with a DNA Virus

Science, 1966
In HEp-2 cells infected with herpes simplex virus the rate of protein synthesis at first decline, is stimulated between 4 and 8 hours after infection, and progressively and irreversibly declines from 9 to 16 hours later. The increase and decrease in rates coincide with corresponding changes in the amounts of cytoplasmic polysomes and amounts of labeled
R J, Sydiskis, B, Roizman
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Unstable DNA synthesized by polyoma virus-infected cells

Virology, 1966
Confluent mouse embryo monolayer cultures are induced by infection with polyoma virus to synthesize DNA which behaves on columns of methylated albumin and upon band centrifugation like cellular DNA. “Pulse-chase” experiments revealed that this DNA, in contrast to normal cellular DNA, is degraded in the infected cultures to a molecular weight ...
T, Ben-Porat, C, Coto, A S, Kaplan
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Infectivities of native and cloned DNA of cauliflower mosaic virus

Gene, 1980
Infectivity assays on turnips reveal that (i) cauliflower mosaic virus (CaMV) DNA, whether circular or linear, is as infectious as the complete virus; (ii) linear DNA obtained with restriction enzymes from the native CaMV DNA has the same specific infectivity as when first cloned in plasmid (pBR322) or bacteriophage (lambda gtWES) vectors and then ...
G, Lebeurier, L, Hirth, T, Hohn, B, Hohn
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RNA recognition by PKR during DNA virus infection

Journal of Medical Virology
Abstract Protein kinase R (PKR) is a double‐stranded RNA (dsRNA) binding protein that plays a crucial role in innate immunity during viral infection and can restrict both DNA and RNA viruses. The potency of its antiviral function is further reflected by the large number of viral‐encoded PKR antagonists.
Ruilin, Zhang, John, Karijolich
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