Results 101 to 110 of about 4,207,382 (399)
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
A bead-based multiplex assay for the detection of DNA viruses infecting laboratory rodents. [PDF]
PLoS ONE, 2014 The Federation of European Laboratory Animal Science Association (FELASA) recommends screening of laboratory rodents and biological materials for a broad variety of bacterial agents, viruses, and parasites.
Daniela Höfler +4 more
doaj +1 more source
IMG/VR: a database of cultured and uncultured DNA Viruses and retroviruses
Nucleic Acids Res., 2016 Viruses represent the most abundant life forms on the planet. Recent experimental and computational improvements have led to a dramatic increase in the number of viral genome sequences identified primarily from metagenomic samples.
A. D. Páez-Espino +31 more
semanticscholar +1 more source
Deletion mutants of bacteriophage phiX174 [PDF]
, 1972 Mutants of bacteriophage phiX174 have been isolated that are less dense than wild-type phiX particles in CsCl. When mutant viral (+) strand DNA and wild-type complementary (-) strand DNA are hybridized, the resulting duplex molecules have single-stranded
Benbow, Robert M. +2 more
core
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Viva lavidaviruses! Five features of virophages that parasitize giant DNA viruses
PLoS Pathogens, 2019 Viruses are obligate intracellular parasites and thus cannot replicate outside a living cell. Whereas a susceptible and permissive host cell is sufficient for most viruses to produce infectious progeny, some viruses such as satellite viruses require two ...
S. Duponchel, M. Fischer
semanticscholar +1 more source
Sunlight-mediated inactivation of health-relevant microorganisms in water: a review of mechanisms and modeling approaches. [PDF]
, 2018 Health-relevant microorganisms present in natural surface waters and engineered treatment systems that are exposed to sunlight can be inactivated by a complex set of interacting mechanisms.
Boehm, Alexandria +16 more
core +1 more source
Molecular Oncology, EarlyView.Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande +11 more
wiley +1 more source
Viruses, 2016 In recent years, it has been suggested that host cells exert intrinsic mechanisms to control nuclear replicating DNA viruses. This cellular response involves nuclear antiviral factors targeting incoming viral genomes.
Tetsuro Komatsu, K. Nagata, H. Wodrich
semanticscholar +1 more source
Virus taxonomy: the database of the International Committee on Taxonomy of Viruses (ICTV) [PDF]
, 2017 The International Committee on Taxonomy of Viruses (ICTV) is charged with the task of developing, refining, and maintaining a universal virus taxonomy.
Dempsey, Donald M. +5 more
core +3 more sources