Results 101 to 110 of about 8,074 (224)
Multifunctional targeting micelle nanocarriers with both imaging and therapeutic potential for bladder cancer. [PDF]
, 2012 BackgroundWe previously developed a bladder cancer-specific ligand (PLZ4) that can specifically bind to both human and dog bladder cancer cells in vitro and in vivo. We have also developed a micelle nanocarrier drug-delivery system.
de Vere White, Ralph +8 more
core +2 more sources
Endogenously Triggered DNAzyme‐Based Nanostructures for Gene‐Combined Therapy
Advanced NanoBiomed ResearchTherapeutic DNAzyme, often activated by catalytic cofactors in its central catalytic domain, has been extensively explored for the treatment of diverse diseases, primarily through mechanisms involving free release, notably within gene therapy frameworks.
Theoneste Muyizere +4 more
doaj +1 more source
International Journal of Electrochemical Science, 2017 We developed a simple, label-free, DNAzyme-based electrochemical impedance sensor for highly sensitive detection of Cu2+ ions in aqueous solution. A complex of Cu2+-dependent DNAzyme and its corresponding substrate was immobilized on the gold electrode ...
Jikui Wu +4 more
doaj +1 more source
Hitting bacteria at the heart of the central dogma: sequence-specific inhibition [PDF]
, 2007 An important objective in developing new drugs is the achievement of high specificity to maximize curing effect and minimize side-effects, and high specificity is an integral part of the antisense approach.
Louise Rasmussen +2 more
core +2 more sources
Journal of Analytical Science and TechnologyAberrant expression of microRNAs (miRNAs) has been shown to be linked to several crucial biological processes, including as carcinogenesis, metastasis, and progression.
Yanyan Pan, Yehong Xu
doaj +1 more source
Nanomaterials, 2018 Silver, a very common heavy metal, has been employed in electronics, medicine, jewelry, and catalysis due to its excellent chemical and physical characteristics. Silver-containing wastes can cause environmental pollution, so it is vital to monitor the Ag(
Hui Wang, Yang Liu, Gang Liu
doaj +1 more source
G-quadruplex DNA aptamers and their ligands: Structure, function and application [PDF]
, 2012 Highly specific and tight-binding nucleic acid aptamers have been selected against a variety of molecular targets for over 20 years. A significant proportion of these oligonucleotides display G-quadruplex structures, particularly for DNA aptamers, that ...
Shum, KT, Tanner, JA, Tucker, WO
core +1 more source
Hemin/G-quadruplex DNAzyme for Designing of Electrochemical Sensors
International Journal of Electrochemical Science, 2015 Guanine-rich nucleic acid sequence can fold into guanine quadruplex (G-quadruplex) that is found to complex tightly with hemin to form the hemin/G-quadruplex.
Guo-Cheng Han +2 more
doaj +1 more source
Molecularly targeted therapies for asthma: current development, challenges and potential clinical translation [PDF]
, 2016 Extensive research into the therapeutics of asthma has yielded numerous effective interventions over the past few decades. However, adverse effects and ineffectiveness of most of these medications especially in the management of steroid resistant severe ...
Lim, Jonathan Chee Woei +3 more
core +1 more source
Recent advances in cytokine detection by immunosensing [PDF]
, 2016 not availableGuozhen Liu, Meng Qi, Mark R.
Goldys, E. +4 more
core +1 more source