The 8-17 DNAzyme can operate in a single active structure regardless of metal ion cofactor
Nature CommunicationsDNAzymes – synthetic enzymes made of DNA — have long attracted attention as RNA-targeting therapeutic agents. Yet, as of now, no DNAzyme-based drug has been approved, partially due to our lacking understanding of their molecular mode of action.
Julia Wieruszewska +5 more
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International Journal of Nanomedicine, 2021 Yang J, Zhang J, Xing J, Shi Z, Han H, Li Q. Int J Nanomedicine. 2019;14:6371– 6385. The authors have advised that during the assembly of subfigures in the preparation stage of the manuscript, two images in each of the Figure S8 and Figure S9 were ...
Yang J +5 more
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Chemosensors, 2022 Calprotectin (CP) is an established biomarker that allows the noninvasive evaluation of inflammation levels in the gastrointestinal tract of patients with inflammatory bowel disease and is helpful for the diagnosis and management of the disease.
Jingyi Si +5 more
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Label-Free, Highly Sensitive Electrochemical Aptasensors Using Polymer-Modified Reduced Graphene Oxide for Cardiac Biomarker Detection [PDF]
, 2020 Acute myocardial infarction (AMI), also recognized as a ???heart attack,??? is one leading cause of death globally, and cardiac myoglobin (cMb), an important cardiac biomarker, is used for the early assessment of AMI.
Bhardwaj, Jyoti +2 more
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The 10–23 DNAzyme in Biosensing and Diagnostics: Applications, Challenges, and Future Directions
Angewandte Chemie, Volume 138, Issue 18, 27 April 2026.This review focuses on the 10–23 DNAzyme in diagnostics, spanning unregulated and regulated target‐recognition modes, and their functionalization across colorimetric, fluorescent, electrochemical, electrochemiluminescent, and intracellular biosensing strategies.
Connor Nurmi +5 more
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DNAzyme conjugated nanomaterials for biosensing applications
Reviews in Analytical Chemistry, 2014 DNAzymes are a series of functional oligonucleotides obtained through in vitro selection and able to catalyze the reaction of substrates with the help of some special cofactors such as metal ions, L-histidine and hemin.
Gong Liang +5 more
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Spiropyran modified micro-fluidic chip channels as photonically controlled self-indicating system for metal ion accumulation and release [PDF]
, 2009 In this paper, we show how through integrating the beneficial characteristics of micro-fluidic devices and spiropyrans dyes, a simple and very innovative chip configured as an on-line photonically controlled self-indicating system for metal ion ...
Attia +51 more
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Molecular diversity and high virulence of Legionella pneumophila strains isolated from biofilms developed within a warm spring of a thermal spa. [PDF]
, 2013 International audienceABSTRACT: BACKGROUND: Several cases of legionellosis have been diagnosed in the same French thermal spa in 1986, 1994 and 1997. L.
Atlan, Danièle +6 more
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First DNAzyme Structure Obtained [PDF]
C&EN Global Enterprise, 2016 For about two decades, chemists have been synthesizing libraries of single-stranded DNAs and screening them for ones that can catalyze specific reactions.
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A general approach to high-yield biosynthesis of chimeric RNAs bearing various types of functional small RNAs for broad applications. [PDF]
, 2015 RNA research and therapy relies primarily on synthetic RNAs. We employed recombinant RNA technology toward large-scale production of pre-miRNA agents in bacteria, but found the majority of target RNAs were not or negligibly expressed. We thus developed a
Chen, Qiu-Xia +4 more
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