Programmable, Universal DNAzyme Amplifier Supporting Pancreatic Cancer-Related miRNAs Detection
Chemosensors, 2022 The abnormal expression of miRNA is closely related to the occurrence of pancreatic cancer. Herein, a programmable DNAzyme amplifier for the universal detection of pancreatic cancer-related miRNAs was proposed based on its programmability through the ...
Kunhan Nie +7 more
doaj +1 more source
Extra-telomeric functions of telomerase in the pathogenesis of Epstein-Barr virus-driven B-cell malignancies and potential therapeutic implications [PDF]
, 2018 The Epstein-Barr virus (EBV) is a ubiquitous human \u3b3-herpesvirus causally linked to a broad spectrum of both lymphoid and epithelial malignancies.
Celeghin, Andrea +4 more
core +1 more source
Peroxidase mimicking DNAzymes degrade graphene oxide [PDF]
Nanoscale, 2018 A DNAzyme made of guanine-rich DNA and hemin is capable of degrading graphene oxide sheets in the presence of hydrogen peroxide similarly to the natural enzyme horseradish peroxidase.
Rajendra Kurapati, Alberto Bianco
openaire +2 more sources
Combination of RCA and DNAzyme for Dual-Signal Isothermal Amplification of Exosome RNA
Molecules, 2023 The RNA contained in exosomes plays a crucial role in information transfer between cells in various life activities. The accurate detection of low-abundance exosome RNA (exRNA) is of great significance for cell function studies and the early diagnosis of
Yuqing Xia +6 more
doaj +1 more source
DNA sensing by electrocatalysis with hemoglobin [PDF]
, 2012 Electrocatalysis offers a means of electrochemical signal amplification, yet in DNA-based sensors, electrocatalysis has required high-density DNA films and strict assembly and passivation conditions.
Barton, Jacqueline K. +2 more
core +2 more sources
DNA Flap‐Mediated Control of Transcription for Programmable RNA Synthesis
Angewandte Chemie, Volume 138, Issue 18, 27 April 2026.Pyrimidine‐rich ssDNA flaps on the T7 promoter inhibit T7 RNA polymerase (T7RP) transcription. Leveraging this pyrimidine bias, we developed DNAzyme‐ and MNAzyme‐mediated flap promoter induced transcription control (D‐FIT and M‐FIT) systems. These platforms enable regulated transcription and sequence‐specific detection, highlighting the programmable ...
Eun Sung Lee +5 more
wiley +2 more sources
Scientific Reports, 2017 Integrin alpha-4 (ITGA4) is a validated therapeutic target for multiple sclerosis (MS) and Natalizumab, an antibody targeting ITGA4 is currently approved for treating MS. However, there are severe side effects related to this therapy.
Madhuri Chakravarthy +3 more
doaj +1 more source
Recent Advances on DNAzyme-Based Biosensors for Detection of Uranyl
Frontiers in Chemistry, 2022 Nuclear facilities are widely used in fields such as national defense, industry, scientific research, and medicine, which play a huge role in military and civilian use.
Yunlong Bai +5 more
doaj +1 more source
Effects of Polyethylene Glycol on DNA Adsorption and Hybridization on Gold Nanoparticles and Graphene Oxide [PDF]
, 2012 This document is the Accepted Manuscript version of a Published Work that appeared in final form in Langmuir, copyright © American Chemical Society after peer review and technical editing by publisher.
Huang, Po-Jung Jimmy +3 more
core +1 more source
Ribozymes for RNA‐Catalyzed RNA Methylation and Labeling
Angewandte Chemie International Edition, EarlyView.Ribozymes are powerful tools for site‐specific RNA modification. Their activities range from installing tags and fluorophores to generating natural RNA methylations, making them valuable tools to uncover the many functions that RNA plays in nature.
Carolin P. M. Scheitl +1 more
wiley +1 more source