Results 181 to 190 of about 8,074 (224)
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Magnetism-Controllable Catalytic Activity of DNAzyme
Analytical Chemistry, 2022Controllable regulation of enzyme activity is an important prerequisite for the in-depth application of enzymes, especially in today's intelligent era. However, irreversible regulation and cumbersome operation make this goal difficult to achieve. Here, by adopting magnetism and a harmless, noncontact, and time- and space-controllable physical element ...
Wenxing Li +7 more
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DNAzymes and their therapeutic possibilities
Internal Medicine Journal, 2009AbstractOur increasing understanding of the regulatory mechanisms involved in the pathogenesis of disease is opening up opportunities for therapeutic intervention. To tackle the unmet disease burden, the last decade has seen the emergence of gene‐targeting small‐molecule nucleic acid‐based strategies, such as antisense oligodeoxynucleotides, ribozymes,
C W S, Chan, L M, Khachigian
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Surface-immobilized DNAzyme-type biocatalysis
Nanoscale, 2014The structure of the double helix of deoxyribonucleic acid (DNA, also called duplex-DNA) was elucidated sixty years ago by Watson, Crick, Wilkins and Franklin. Since then, DNA has continued to hold a fascination for researchers in diverse fields including medicine and nanobiotechnology.
Stefan, Loïc +4 more
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2012
The efficiency of RNA-cleaving DNAzymes depends on a large extent on complex formation with their RNA targets. We describe available prediction tools that should help in the design of efficient DNAzymes and show some experimental methods to test the predictions.
Gerhard, Steger, Julian, Victor
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The efficiency of RNA-cleaving DNAzymes depends on a large extent on complex formation with their RNA targets. We describe available prediction tools that should help in the design of efficient DNAzymes and show some experimental methods to test the predictions.
Gerhard, Steger, Julian, Victor
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Recent Advances on DNAzyme‐Based Sensing
Chemistry – An Asian Journal, 2022AbstractOwing to the high sensitivity, excellent programmability, and flexible obtainment through in vitro selection, RNA‐cleaving DNAzymes have attracted increasing interest in developing DNAzyme‐based sensors. In this review, we summarize the recent advances on DNAzyme‐based sensing applications. We initially conclude two general strategies to expand
Zhimei Huang +3 more
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DNAzymes in Environmental Sensing
Critical Reviews in Environmental Science and Technology, 2006DNAzymes are biocatalysts with a promising capacity to selectively identify charged organic and inorganic compounds at ultratrace levels in industrial waste streams, chemical emissions, environmental samples, or biological systems for a variety of applications. Combining the specificity of nano-biological recognition probes and the sensitivity of laser-
Raveender Vannela, Peter Adriaens
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pH-triggered switchable Mg2+-dependent DNAzymes
Chemical Communications, 2010The activities of Mg(2+)-dependent DNAzymes are reversibly switched by pH stimuli using the i-motif as an activating motif.
Johann, Elbaz +2 more
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DNAzyme-Mediated Silencing of Ornithine Decarboxylase
Biochemistry, 2005The value of reducing the activity of ornithine decarboxylase (ODC), a key enzyme in the biosynthesis of polyamines, is well-appreciated. Polyamines are necessary components for cell growth, and manipulation of polyamine homeostasis may be an effective strategy for the treatment of a number of disorders, including neoplastic diseases.
Joseph M, Ackermann +2 more
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A new Pb2+-specific DNAzyme by revisiting the catalytic core of 10–23 DNAzyme
Bioorganic & Medicinal Chemistry, 202010-23 DNAzyme is a catalytic DNA molecule from in vitro selection, the 15-mer catalytic core was investigated for more DNAzyme variants by block deletions. DNAzyme DZM01 was selected with metal ion dependence of Pb2+ ≫ Mn2+, with no activity in the presence of Mg2+ (20 mM), Ca2+ (20 mM), Zn2+ (20 mM, pH 6).
Yang, Li +3 more
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DNAzymes: Selected for Applications
Small Methods, 2018AbstractDNA‐based enzymes, also known as deoxyribozymes or DNAzymes, are single‐stranded DNA molecules with catalytic activity. DNAzymes do not exist in nature but can be isolated from random‐sequence DNA pools using in vitro selection. To date, many DNAzymes that collectively catalyze a diverse range of chemical transformations have been reported ...
Devon Morrison +2 more
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