Results 191 to 200 of about 8,074 (224)
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DNAzyme amplification of molecular beacon signal
Talanta, 2005This paper reports an improved catalytic molecular beacon. Addition of the target oligonucleotide activates a DNA enzyme (DNAzyme), which, in turn, activates multiple copies of molecular beacons (MB) and gives rise to a strong fluorescence signal.
Ye, Tian, Chengde, Mao
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Aptamer−DNAzyme Hairpins for Amplified Biosensing
Analytical Chemistry, 2009Engineered nucleic acid hairpin structures are used for the amplified analysis of low-molecular-weight substrates (adenosine monophosphate, AMP) or proteins (lysozyme). The hairpin structures consist of the anti-AMP or antilysozyme aptamer units linked to the horseradish peroxidase (HRP)-mimicking DNAzyme sequence. The HRP-mimicking DNAzyme sequence is
Carsten, Teller +2 more
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DNAzym gegen allergisches Asthma
Pneumo News, 2015Einen eleganten Weg erproben deutsche Forscher in der Asthmabekampfung: Statt Antikorper gegen Zytokine zu schmieden, setzen sie direkt an einem Transkriptionsfaktor an, der die Zytokinrezeptoren auf der Oberflache von T2-Helferzellen reguliert.
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DNAzyme Delivery Approaches in Biological Settings
Current Medicinal Chemistry, 2013DNAzymes are DNA-based catalytic molecules that have potential use in a range of disorders where the targeted gene plays an important role in disease pathogenesis. DNAzymes are at a comparatively early developmental stage as alternatives to conventional therapies.
Cecilia W S, Chan, Levon M, Khachigian
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Dnazyme-Based Therapeutics for Cancer Treatment
Future Medicinal Chemistry, 2015Gene-silencing strategies based on catalytic nucleic acids have been rapidly developed in the past decades. Ribozymes, antisense oligonucleotides and RNA interference have been actively pursued for years due to their potential application in gene inactivation.
Shujun, Fu, Lun-Quan, Sun
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Allergen Responses Modified by a GATA3 DNAzyme
New England Journal of Medicine, 2015----
CARAMORI, Gaetano +2 more
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Resurrecting DNAzymes as Sequence-Specific Therapeutics
Science Translational Medicine, 2012In a skin cancer model, intratumoral injection of an mRNA-cleaving DNA enzyme inhibited tumor growth with benign pharmacodynamics.
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Nucleic Acid Sequence Analysis Using DNAzymes
2004The sequence specificity of the "10-23" RNA-cleaving DNA enzyme can be utilized to discriminate between subtle differences in nucleic acid sequence. We examined this potential by comparing the cleavage activity of DNAzymes that target sequences derived from a relatively conserved segment of the L1 gene from different human papillomavirus (HPV ...
Murray J, Cairns, Lun-Quan, Sun
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DNAzyme-Functionalized Gold Nanoparticles for Biosensing
2013Recent progress in using DNAzyme-functionalized gold nanoparticles (AuNPs) for biosensing is summarized in this chapter. A variety of methods, including those for attaching DNA on AuNPs, detecting metal ions and small molecules by DNAzyme-functionalized AuNPs, and intracellular applications of DNAzyme-functionalized AuNPs are discussed.
Yu, Xiang +3 more
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