Results 41 to 50 of about 8,074 (224)
Biophysically inspired rational design of structured chimeric substrates for DNAzyme cascade engineering. [PDF]
PLoS ONE, 2014 The development of large-scale molecular computational networks is a promising approach to implementing logical decision making at the nanoscale, analogous to cellular signaling and regulatory cascades.
Matthew R Lakin +6 more
doaj +1 more source
Fluorescent sensors using DNA-functionalized graphene oxide [PDF]
, 2014 The final publication is available at Springer via http://dx.doi.org/10.1007/s00216-014-7888-3In the past few years, graphene oxide (GO) has emerged as a unique platform for developing DNA-based biosensors, given the DNA adsorption and fluorescence ...
Ding, Jinsong +3 more
core +1 more source
Detection of Vibrio vulnificus in Seafood With a DNAzyme-Based Biosensor
Frontiers in Microbiology, 2021 Vibrio vulnificus is an important pathogenic bacterium that is often associated with seafood-borne illnesses. Therefore, to detect this pathogen in aquatic products, a DNAzyme-based fluorescent sensor was developed for the in vitro detection of V ...
Shihui Fan +29 more
doaj +1 more source
Searching for a DNAzyme version of the leadzyme [PDF]
, 2015 The final publication is available at Springer via http://dx.doi.org/10.1007/s00239-015-9702-zThe leadzyme refers to a small ribozyme that cleaves a RNA substrate in the presence of Pb2+. In an optimized form, the enzyme strand contains only two unpaired
Chen, Qingyun +2 more
core +1 more source
Alkyltransferase Ribozyme for Site‐Specific N4‐Cytidine Alkylation
Angewandte Chemie, EarlyView.CSAR is the first ribozyme that catalyzes direct alkylation of an exocyclic amino group of an RNA nucleobase. The ribozyme was isolated as a self‐labeling catalyst from an in vitro selection library and engineered into a trans‐active ribozyme that catalyzes the transfer of a benzyl group from an O6‐modifed guanine to the N4 amino group of a specific ...
Evgeniia Dorinova +2 more
wiley +2 more sources
Science and Technology of Advanced Materials, 2016 Deoxyribozymes (DNAzymes) having RNA-cleaving activity have widely been explored as tools for therapeutic and diagnostic purposes. Both the chemical cleaving step and the turnover step should be improved for enhancing overall activity of DNAzymes.
Ken Saito +2 more
doaj +1 more source
Two Pb2+-specific DNAzymes with opposite trends in split-site-dependent activity [PDF]
, 2014 By splitting the catalytic core of DNAzymes into two halves, two Pb2+-specific DNAzymes retain partial activity, while they show opposite trends of activity as a function of the split site, revealing important nucleotides for catalysis and metal binding ...
Huang, Po-Jung Jimmy, Liu, Juewen
core +1 more source
Biosensors, 2022 Biological water contamination detection-based assays are essential to test water quality; however, these assays are prone to false-positive results and inaccuracies, are time-consuming, and use complicated procedures to test large water samples. Herein,
Sakandar Rauf +6 more
doaj +1 more source
Electrochemical detection of miRNAs [PDF]
, 2014 The recent progress made in the development of electrochemical methods for microRNA (miRNA) detection is presented. This progress is conceived to be largely due to the invention of novel assay methodologies and the use of various bioreagents and ...
Gyurcsányi, Ervin Róbert +1 more
core +1 more source
Detection of Bacteria Using Fluorogenic DNAzymes [PDF]
Journal of Visualized Experiments, 2012 Outbreaks linked to food-borne and hospital-acquired pathogens account for millions of deaths and hospitalizations as well as colossal economic losses each and every year. Prevention of such outbreaks and minimization of the impact of an ongoing epidemic place an ever-increasing demand for analytical methods that can accurately identify culprit ...
Aguirre, Sergio D. +3 more
openaire +2 more sources