Results 101 to 110 of about 1,137,951 (298)
Finding aid for personal papers of Madison County, Kentucky fiddler and recording artist, Doc Roberts in the Berea College Southern Appalachian Archives.
Doc Roberts
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
, 1965 Photograph of Bill Monroe and Doc Watson performing on stage at Roanoke Bluegrass Festival, at Cantrells Horse Farm in Fincastle ...
Monroe, Bill; Watson, Arthel 'Doc', 3/3/1923- ;
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Resorption of Augmenting Materials Used in Sinus Lift Operation
Česká Stomatologie a Praktické Zubní Lékařství, 2006 In certain cases conditions in oral cavity for introducing dental implants should be prepared before the operation. In lateral section of upper jaw the augmenting sinus lift procedure is almost an indispensable part of implantological therapy. The aim of
T. Brázda +4 more
doaj
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Representação de comunidades e identidade cultural [PDF]
Presentation of issue 37 of the DOC On-line magazine.Presentación del número 37 de la revista DOC On-line.Présentation du numéro 37 du magazine DOC On-line.Apresentação da edição 37 da revista DOC On ...
Penafria, Manuela, Freire, Marcius
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source