Results 121 to 130 of about 1,137,951 (298)

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

Clinical Evaluation of Problems Originated after Cementing Fixed Partial Dentures

open access: yesČeská Stomatologie a Praktické Zubní Lékařství, 2006
The clinical procedures involved in fixed partial dentures, can produce variety of responses from the dental pulp, periodontal tissue, and associated anatomic structures. In this article, some of the major problems that may occur after cemention of fixed
A. Boldaji, E. Cimbura
doaj  

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

open access: yesMolecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira   +7 more
wiley   +1 more source

Methods of Vital Pulp Therapy - Direct Pulp Capping

open access: yesČeská Stomatologie a Praktické Zubní Lékařství, 2007
In this long-term, clinical study, the authors are concerned with the history, development and contemporary possibilities of vital pulp therapy. Our department has been for more than thirty years engaged in following of repair processes in the dental ...
E. Záhlavová, J. Netolický
doaj  

Revolução Cubana e documentário – 60 anos

open access: yes, 2019
Full version Versión integral Versión intégraleVersão ...
On-Line, DOC
core  

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

open access: yesMolecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh   +11 more
wiley   +1 more source

Internal Granuloma - Present State of the Problem

open access: yesČeská Stomatologie a Praktické Zubní Lékařství, 2007
It has been generally acknowledged that internal granuloma (internal resorption, granuloma internum) originates on the basis of disorder of pulp metabolism, associated with degenerative processes, which follow to chronic inflammation of tooth pulp.The ...
J. Netolický, E. Záhlavová
doaj  

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

Clinical Evaluation of Facet Materials in Fixed Prosthodontics (Part 2)

open access: yesČeská Stomatologie a Praktické Zubní Lékařství, 2006
The aim and purpose of this study was to evaluate the long-term stability of facet crowns, the changes of facet surface, marginal adaptation, cracks or breakage of material, change of shape and colour as well as gingival status and finally the search for
A. Boldaji, E. Cimbura
doaj  

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

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