ABSTRACT Background Nuclear protein in testis (NUT) carcinoma is a rare, aggressive malignancy driven by NUTM1 rearrangement, often misdiagnosed as squamous cell carcinoma, with no established standard therapy. This report describes the clinical course and treatment resistance in primary laryngeal NUT carcinoma and provides insights into potential ...
Masafumi Kanno +15 more
wiley +1 more source
Excessive Tearing and Lacrimal and Canalicular Blockage Secondary to Docetaxel in Breast Cancer Patients in the Metastatic and Adjuvant Settings. [PDF]
Pfeiffer ML, Esmaeli B.
europepmc +1 more source
Cancer-Control Outcomes of Japanese Vs. German Metastatic Hormone-Sensitive Prostate Cancer Patients: A Real-World Cross-Country Comparison of Patients Undergoing Combination Therapies. [PDF]
ABSTRACT Objectives Differences in tumor biology, ethnicities, and healthcare structures across populations may contribute to variability in oncologic outcomes. This study compared baseline characteristics and oncologic outcomes of Japanese and German metastatic hormone‐sensitive prostate cancer (mHSPC) patients.
Wenzel M +13 more
europepmc +2 more sources
ABSTRACT Background Androgen deprivation therapy (ADT) is the base of treatment for prostate cancer, and gonadotropin‐releasing hormone (GnRH) drugs are given as depot injections. Long‐acting formulations may reduce the number of injections and the drug cost, but this impact has not been quantified in real practice.
Takashi Kawahara +7 more
wiley +1 more source
Complete Response to Concurrent Triplet Therapy in Low-Volume Metastatic Hormone-Sensitive Prostate Cancer: A Case Report. [PDF]
Fujita T +4 more
europepmc +1 more source
Lactoferrin and Nanotechnology: New Insights Into Glioblastoma Therapy
Current glioblastoma multiforme (GBM) management primarily relies on surgery, chemotherapy, and radiotherapy; however, therapeutic efficacy remains limited due to tumor invasiveness and restricted drug penetration across the blood–brain barrier. Lactoferrin (LF), an iron‐binding glycoprotein with receptor‐mediated transport capability, has emerged as a
Atena Abed, Javad Amini Mahabadi
wiley +1 more source
Gemcitabine-Based Bladder Preservation in BCG-Unresponsive High-Risk NMIBC: Evidence, Limitations, and Clinical Positioning. [PDF]
Kaltsas A +9 more
europepmc +1 more source
This study prospectively evaluated the efficacy and safety of the bevacizumab, nab‐paclitaxel and platinum combination as a second‐line therapy for driver‐gene‐negative advanced non‐squamous non‐small cell lung cancer after immunochemotherapy. The confirmed objective response rate was 46.4%.
Ying Lin +12 more
wiley +1 more source
PIGL promotes the docetaxel resistance of prostate cancer and is regulated by E3 ubiquitin ligase HUWE1. [PDF]
Gao P +7 more
europepmc +1 more source
Non‐Metastatic Squamous Cell Carcinoma of the Oropharynx: Primary Surgery or (Chemo)radiotherapy?
ABSTRACT Background In patients with locally advanced, non‐metastatic oropharyngeal squamous cell carcinoma (OPSCC), surgery‐based and nonsurgical treatment approaches have not been adequately compared in randomized Phase III clinical trials. Current clinical guidelines recommend various surgical and nonsurgical strategies across disease stages for ...
Primož Strojan +12 more
wiley +1 more source

