Results 21 to 30 of about 98,224 (178)

A systematic review of the effectiveness of docetaxel and mitoxantrone for the treatment of metastatic hormone-refractory prostate cancer [PDF]

, 2006
A systematic review was performed to evaluate the clinical effectiveness of docetaxel in combination with prednisolone (docetaxel is licensed in the UK for use in combination with prednisone or prednisolone for the treatment of patients with metastatic ...
Riemsma, R., Trowman, R., G Norman, E Fenwick, R Riemsma, Norman, G., Fenwick, E., Birtle, A., Collins, R., K Light, Light, K., A Birtle, Palmer, S., R Collins, S Palmer, R Trowman   +15 more
core   +1 more source

Ritonavir inhibits intratumoral docetaxel metabolism and enhances docetaxel antitumor activity in an immunocompetent mouse breast cancer model [PDF]

, 2016
Docetaxel (Taxotere(®) ) is currently used intravenously as an anticancer agent and is primarily metabolized by Cytochrome P450 3A (CYP3A). The HIV protease inhibitor ritonavir, a strong CYP3A4 inhibitor, decreased first-pass metabolism of orally ...
Schellens, Jan H M, Song, Ji Ying, Jan H.M. Schellens, Rottenberg, Sven, Beijnen, Jos H., Lagas, Jurjen S, Sven Rottenberg, Lagas, Jurjen S., Hendrikx, Jeroen J M A, Jurjen S. Lagas, Song, Ji-Ying, Pharmacoepidemiology and Clinical Pharmacology, Ji‐Ying Song, Hilde Rosing, Schinkel, Alfred H, Sub Clinical Pharmacology, Jeroen J.M.A. Hendrikx, Rosing, Hilde, Jos H. Beijnen, Beijnen, Jos H, Schinkel, Alfred H., Alfred H. Schinkel   +21 more
core   +2 more sources

Docetaxel Toxicity Optimization in Esophageal Squamous Cell Carcinoma Cell Line YM-1: A Study of Cell Cycle and Doubling Time Effect

Medical Laboratory Journal, 2021
Background and objectives: Docetaxel is a chemotherapeutic agent commonly used for treatment of many cancers, including esophageal squamous cell carcinoma. Docetaxel induces G2/M phase cell cycle arrest and ultimately cell death.
Boshra haghi, Marie Saghaeian jazi, Mahdi zarie, Ayyoob Khosravi, mahboubeh tajaldini, Jahanbakhsh Asadi   +5 more
doaj  

Formation of Docetaxel-related Substances in the Polymer Particles During Storage and Gamma-treatment

Разработка и регистрация лекарственных средств, 2020
Introduction. Docetaxel is widely used for cancer treatment. Actual issue for newly developed polymer-based Docetaxel formulations is applicability of current quality requirements.
Yu. I. Poltavets, S. V. Aleshin, V. V. Zavarzina, A. I. Murav’eva, A. A. Soboleva, I. A. Tubasheva, S. L. Kuznetsov   +6 more
doaj   +1 more source

Pharmacokinetic analysis of two different docetaxel dose levels in patients with non-small cell lung cancer treated with docetaxel as monotherapy or with concurrent radiotherapy

BMC Cancer, 2007
Background Previous pharmacokinetic studies with docetaxel have mostly used 3-weekly (75 mg/m2 and 100 mg/m2) or weekly regimens (35–40 mg/m2). The pharmacokinetics and radiosensitizing efficacy of weekly 20 mg/m2 docetaxel, has however not been well ...
Kristensen Vessela, Aamdal Steinar, Andersen Anders, Fr Brunsvig Paal, Olsen Harald   +4 more
doaj   +1 more source

Knockdown of USP8 inhibits prostate cancer cell growth, proliferation, and metastasis and promotes docetaxel’s activity by suppressing the NF-kB signaling pathway

Frontiers in Oncology, 2022
Ubiquitin-specific protease 8 (USP8) has been recently reported to be involved in tumorigenesis. Prostate cancer (PCa) is the most diagnosed malignancy among men, but USP8’s role in PCa is not yet investigated comprehensively.
Md. Tariqul Islam, Fang-Zhi Chen, Han-Chun Chen, Abdul Wahid   +3 more
doaj   +1 more source

The effects of docetaxel and/or captopril in expression of TGF-β1, MMP-1, CTGF, and PAI-1 as markers of anterior urethral stricture in an animal model

Therapeutic Advances in Urology, 2020
Background: Treatment of urethral trauma is currently done after urethral stricture occurs. Stricture therapy after occurrence gives unsatisfactory success rates. Several genes, such as transforming growth factor beta 1 (TGF-β1), matrix metalloproteinase 
Wikan Kurniawan, Marsetyawan Heparis Nur Ekandaru Soesatyo, Teguh Aryandono   +2 more
doaj   +1 more source

Study of the radiosensitization of docetaxel in human esophageal squamous carcinoma ECA109 cell line

Pakistan Journal of Pharmaceutical Sciences, 2021
The aim of this study was to determine the radio sensitization of docetaxel in human esophageal squamous carcinoma ECA109 cell line by observing the effects of docetaxel in ECA109 cell proliferation, cell cycle distribution, apoptosis rate and related ...
Li He, Liang Dong, Sujing Zhang, Yongqian Zhang, Zheng Zheng, Ying Guo, Liping Guo, Changwen Bo   +7 more
doaj   +1 more source

Combination treatment of docetaxel with caffeic acid phenethyl ester suppresses the survival and the proliferation of docetaxel-resistant prostate cancer cells via induction of apoptosis and metabolism interference

Journal of Biomedical Science, 2022
Background Docetaxel has been approved by USFDA as a first-line treatment for castration-resistant prostate cancer (CRPC) patients. Patients receiving androgen deprivation therapy along with docetaxel result in superior survival, lower serum prostate ...
Yu-Ke Fu, Bi-Juan Wang, Jen-Chih Tseng, Shih-Han Huang, Ching-Yu Lin, Ying-Yu Kuo, Tzyh-Chyuan Hour, Chih-Pin Chuu   +7 more
doaj   +1 more source

Endothelial Cells Promote Docetaxel Resistance of Prostate Cancer Cells by Inducing ERG Expression and Activating Akt/mTOR Signaling Pathway

Frontiers in Oncology, 2020
Docetaxel is a first-line chemotherapy for the treatment of patients with castration-resistant prostate cancer (CRPC). Despite the good initial response of docetaxel, drug resistance will inevitably occur.
Wenhao Zhou, Yiming Su, Yu Zhang, Bangmin Han, Haitao Liu, Xiaohai Wang   +5 more
doaj   +1 more source