Results 61 to 70 of about 1,575 (172)

Genome-wide analysis of acetivibrio cellulolyticus provides a blueprint of an elaborate cellulosome system

BMC Genomics, 2012
Background Microbial degradation of plant cell walls and its conversion to sugars and other byproducts is a key step in the carbon cycle on Earth. In order to process heterogeneous plant-derived biomass, specialized anaerobic bacteria use an elaborate ...
Dassa Bareket, Borovok Ilya, Lamed Raphael, Henrissat Bernard, Coutinho Pedro, Hemme Christopher L, Huang Yue, Zhou Jizhong, Bayer Edward A   +8 more
doaj   +1 more source

Coarse-Grained MD Simulations and Protein−Protein Interactions: The Cohesin−Dockerin System

Journal of Chemical Theory and Computation, 2009
Coarse-grained molecular dynamics (CG-MD) may be applied as part of a multiscale modeling approach to protein-protein interactions. The cohesin-dockerin interaction provides a valuable test system for evaluation of the use of CG-MD, as structural (X-ray) data indicate a dual binding mode for the cohesin-dockerin pair.
Hall, B, Sansom, M
openaire   +2 more sources

Intramolecular clasp of the cellulosomal Ruminococcus flavefaciens ScaA dockerin module confers structural stability [PDF]

FEBS Open Bio, 2013
The cellulosome is a large extracellular multi‐enzyme complex that facilitates the efficient hydrolysis and degradation of crystalline cellulosic substrates. During the course of our studies on the cellulosome of the rumen bacterium Ruminococcus flavefaciens, we focused on the critical ScaA dockerin (ScaADoc), the unique dockerin that incorporates the ...
Slutzki, Michal, Jobby, Maroor K., Chitayat, Seth, Karpol, Alon, Dassa, Bareket, Barak, Yoav, Lamed, Raphael, Smith, Steven P., Bayer, Edward A.   +8 more
openaire   +2 more sources

Artificial Enzymatic Electrochemistry

ChemElectroChem, Volume 12, Issue 21, November 3, 2025.
Artificial enzymatic electrochemistry has emerged as an effective method to extend the catalytic abilities of enzymes. This review explores the bioelectrochemical methods used to understand and optimize the structure and function of artificial enzymes.
Nya E. Black, Dara Cheng, Brandon P. Grasty, Dylan G. Boucher   +3 more
wiley   +1 more source

Unraveling essential cellulosomal components of the (Pseudo)Bacteroides cellulosolvens reveals an extensive reservoir of novel catalytic enzymes

Biotechnology for Biofuels, 2019
Background (Pseudo)Bacteroides cellulosolvens is a cellulolytic bacterium that produces the most extensive and intricate cellulosomal system known in nature. Recently, the elaborate architecture of the B.
Olga Zhivin-Nissan, Bareket Dassa, Ely Morag, Meital Kupervaser, Yishai Levin, Edward A. Bayer   +5 more
doaj   +1 more source

Structural and functional characterization of a novel type‐III dockerin from Ruminococcus flavefaciens [PDF]

FEBS Letters, 2012
ScaB cohesin binds to ScaADoc by enzyme linked immunosorbent assay (View interaction)
Karpol, Alon, Jobby, Maroor K., Slutzki, Michal, Noach, Ilit, Chitayat, Seth, Smith, Steven P., Bayer, Edward A.   +6 more
openaire   +2 more sources

Bioactive polysaccharides and their potential health benefits in reducing the risks of metabolic syndrome: A review

Food Biomacromolecules, Volume 2, Issue 3, Page 288-314, September 2025.
Abstract Metabolic syndrome (MetS) is a complex noncommunicable condition characterized by central obesity, insulin resistance, hyperlipidemia, hypertension, and hyperglycemia. Epidemiological evidence shows that MetS affects a third of the global population; however, due to its complex pathogenesis and limited drug therapy options, the increasing ...
Josiah Owuor Oyalo, Evelyne Nkirote Gikundi, Mercy Adhiambo Ndiege, Kevin Omondi Aduol   +3 more
wiley   +1 more source

Methanotrophic Flexibility of ‘Ca. Methanoperedens’ and Its Interactions With Sulphate‐Reducing Bacteria in the Sediment of Meromictic Lake Cadagno

Environmental Microbiology, Volume 27, Issue 7, July 2025.
In anoxic sediments of the meromictic freshwater Lake Cadagno ‘Ca. Methanoperedens’ and sulphate‐reducing Desulfobacterota QYQD01 co‐occur. Metagenomics revealed that ‘Ca. Methanoperedens’ genomes harbour different extracellular electron transfer pathways.
Maider J. Echeveste Medrano, Guangyi Su, Lucas A. Blattner, Pedro Leão, Irene Sánchez‐Andrea, Mike S. M. Jetten, Cornelia U. Welte, Jakob Zopfi   +7 more
wiley   +1 more source

Transcytosis in the blood–cerebrospinal fluid barrier of the mouse brain with an engineered receptor/ligand system

Molecular Therapy: Methods & Clinical Development, 2015
Crossing the blood–brain and the blood–cerebrospinal fluid barriers (BCSFB) is one of the fundamental challenges in the development of new therapeutic molecules for brain disorders because these barriers prevent entry of most drugs from the blood ...
Héctor R Méndez-Gómez, Albert Galera-Prat, Craig Meyers, Weijun Chen, Jasbir Singh, Mariano Carrión-Vázquez, Nicholas Muzyczka   +6 more
doaj   +1 more source

Crucial Roles of Single Residues in Binding Affinity, Specificity, and Promiscuity in the Cellulosomal Cohesin-Dockerin Interface*

Journal of Biological Chemistry, 2015
Background: Cellulosomal cohesin-dockerin interactions show intraspecies promiscuity but interspecies specificity. Results: A combination of computations and experiments reveals single cohesin residue mutations with dramatic effects not only on binding ...
Michal Slutzki, D. Reshef, Yoav Barak, R. Haimovitz, Shahar Rotem-Bamberger, R. Lamed, E. Bayer, Ora Schueler‐Furman   +7 more
semanticscholar   +1 more source