Results 1 to 10 of about 133,738 (306)

Integrated Network Pharmacology, Molecular Docking and Animal Experiment to Explore the Efficacy and Potential Mechanism of Baiyu Decoction Against Ulcerative Colitis by Enema

Drug Design, Development and Therapy, 2023
Yuan Cui,1,2 Jingyi Hu,2 Yanan Li,1,2 Ryan Au,1,2 Yulai Fang,2 Cheng Cheng,1 Feng Xu,1,2 Weiyang Li,1,2 Yuguang Wu,1,2 Lei Zhu,2 Hong Shen2 1Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China; 2Affiliated Hospital of Nanjing ...
Cui Y, Hu J, Li Y, Au R, Fang Y, Cheng C, Xu F, Li W, Wu Y, Zhu L, Shen H   +10 more
doaj   +3 more sources

From AI-Assisted In Silico Computational Design to Preclinical In Vivo Models: A Multi-Platform Approach to Small Molecule Anti-IBD Drug Discovery [PDF]

Pharmaceuticals
Background: Inflammatory Bowel Disease (IBD), including Ulcerative Colitis and Crohn’s Disease, is a multifactorial inflammatory condition of the intestinal tract driven by a complex interplay of genetic factors, immune system dysfunction, and gut ...
Joya Datta Ripa, Sarfaraz Ali, Matt Field, John Smithson, Phurpa Wangchuk   +4 more
doaj   +2 more sources

Dynamics of Biochemical Parameters, Inflammatory and Stress Markers in Lambs Undergoing Caudectomy Using Two Different Methods [PDF]

Animals
Zootechnical practices such as tail docking are still in use in dairy sheep farming, performed in the first week of life, mainly by rubber ring and only rarely by surgical methods.
Giovannantonio Pilo, Giuseppe Tedde, Angelo Peli, Pier Attilio Accorsi, Gavina Carta, Loredana Secchi, Giulia Franzoni, Paola Nicolussi   +7 more
doaj   +2 more sources

Why are most EU pigs tail docked? Economic and ethical analysis of four pig housing and management scenarios in the light of EU legislation and animal welfare outcomes

Animal, 2016
To limit tail biting incidence, most pig producers in Europe tail dock their piglets. This is despite EU Council Directive 2008/120/EC banning routine tail docking and allowing it only as a last resort.
R.B. D’Eath, J.K. Niemi, B. Vosough Ahmadi, K.M.D. Rutherford, S.H. Ison, S.P. Turner, H.T. Anker, T. Jensen, M.E. Busch, K.K. Jensen, A.B. Lawrence, P. Sandøe   +11 more
doaj   +6 more sources

Molecular docking, simulations of animal peptides against the envelope protein of Dengue virus

Journal of Biomolecular Structure and Dynamics, 2023
Peptides are biologically active, small molecules with high specificity in its mode of action that can be effective at nanomolar concentrations. Peptide-based antiviral medicines have already been licensed and used to treat human immunodeficiency virus (HIV), influenza virus and hepatitis C virus. So far, no peptide drug has been approved for antiviral
Reena, Guntamadugu, Ranjani, Ramakrishnan, Gowtham, Darala, Sangeetha, Kothandan   +3 more
openaire   +2 more sources

SARS-CoV-2 prevalence in domestic and wildlife animals: A genomic and docking based structural comprehensive review

Heliyon, 2023
The SARS-CoV-2 virus has been identified as the infectious agent that led to the COVID-19 pandemic, which the world has seen very recently. Researchers have linked the SARS-CoV-2 outbreak to bats for the zoonotic spread of the virus to humans. Coronaviruses have a crown-like shape and positive-sense RNA nucleic acid.
Tuhin Das, Suranjana Sikdar, Md. Helal Uddin Chowdhury, Khandakar Jannatul Nyma, Md. Adnan   +4 more
openaire   +3 more sources

Nelumbo nucifera Gaertn. leaves: network pharmacology and molecular docking analysis of active ingredients and their mechanisms of action in treating atherosclerosis

Biotechnology & Biotechnological Equipment, 2022
Atherosclerosis is the pathological basis of cardiovascular and cerebrovascular diseases. Nelumbo nucifera Gaertn. leaves are edible, an effective traditional Chinese medicine in the treatment of atherosclerosis, but its mechanisms of action remain ...
Linhai Wang, Zhuoji Guan, Shaodong Li, Xin Dong, Jialin Jiang, Lingjun Wang, Shaoxiang Xian   +6 more
doaj   +1 more source

Whey-derived peptides interactions with ACE by molecular docking as a potential predictive tool of natural ACE inhibitors [PDF]

, 2020
Several milk/whey derived peptides possess high in vitro angiotensin I-converting enzyme (ACE) inhibitory activity. However, in some cases, poor correlation between the in vitro ACE inhibitory activity and the in vivo antihypertensive activity has been ...
Chamata, Yara, Jauregi, Paula, Watson, Kimberly A.   +2 more
core   +1 more source

Improving survival, growth rate, and animal welfare in piglets by avoiding teeth shortening and tail docking [PDF]

Journal of Veterinary Behavior, 2012
Piglets are subjected to several painful procedures during their first week of life, including ear tagging, teeth clipping or grinding (although routinely prohibited in Europe), tail docking (although routinely prohibited in Europe), needle injections (vaccination and iron injection), and castration might be performed for male piglets.
Van Beirendonck, Sanne, Driessen, Bert, Verbeke, Geert, Permentier, Liesbet, Van de Perre, Vincent, Geers, Rony   +5 more
openaire   +2 more sources

Molecular docking and anti-ulcerative potential of Cucumis (L. Inodorous) on ibuprofen induced gastric ulceration in male wistar animals

Biomedicine & Pharmacotherapy, 2023
The use of NSAIDs have caused stomach injury by inhibiting endogenous mucosal prostaglandin production. Cucumis melo is reported to possess antiulcer potential. This study investigates the mechanism underlying the antiulcer potentials of Cucumis melo (CUM).Thirty-five male Wistar rat were randomly assigned to each of seven groups; A(control given water
Grace, Adebayo-Gege, Zainab Shehu, Uthman, Moses Dele, Adams, Tarfa, Florence, Danazumi Umar, Haruna, Ngabea Murtala, Audu, Hamidu Jabba, Lawan, Ozegbe, Queen, Onwuchekwa, Chinedu, Ajibola, Meraiyebu, Ojo, Kafaru   +10 more
openaire   +2 more sources