Results 201 to 210 of about 2,926,121 (366)

PJA2 Suppresses Colorectal Cancer Progression by Controlling HDAC2 Degradation and Stability

Advanced Science, Volume 12, Issue 13, April 3, 2025.
PJA2, an E3 ubiquitin‐protein ligase, actively restrains colorectal cancer (CRC) progression. It targets histone deacetylase 2 (HDAC2) for degradation, which in turn activates the interferon‐induced protein with tetratricopeptide repeats (IFIT) family, effectively hindering tumor growth and promoting apoptosis.
Zhihao Chen, Chaofan Peng, Chi Jin, Ye Wang, Tuo Wang, Peng Yang, Wen Peng, Qingyang Sun, Hengjie Xu, Hongxu Nie, Xiaowei Wang, Junwei Tang, Yueming Sun, Yifei Feng   +13 more
wiley   +1 more source

PoseX: AI Defeats Physics Approaches on Protein-Ligand Cross Docking [PDF]

arXiv
Recently, significant progress has been made in protein-ligand docking, especially in modern deep learning methods, and some benchmarks were proposed, e.g., PoseBench, Plinder. However, these benchmarks suffer from less practical evaluation setups (e.g., blind docking, self docking), or heavy framework that involves training, raising challenges to ...
arxiv  

Excessive MYC Orchestrates Macrophages induced Chromatin Remodeling to Sustain Micropapillary‐Patterned Malignancy in Lung Adenocarcinoma

Advanced Science, Volume 12, Issue 12, March 27, 2025.
Song et al. integrates an evaluating system to characterize malignancy of micropapillary (MP)‐pattern lung adenocarcinoma in vivo or in vitro. They have discovered that intrinsic MYC redundancy expression combined with extrinsic M2‐like macrophage jointly mediate MP‐pattern malignancy.
Xuming Song, Zehao Pan, Yi Zhang, Wenmin Yang, Te Zhang, Hui Wang, Yuzhong Chen, Xinnian Yu, Hanlin Ding, Rutao Li, Pengfei Ge, Lin Xu, Gaochao Dong, Feng Jiang   +13 more
wiley   +1 more source

Blockade of ZMIZ1‐GATA4 Axis Regulation Restores Youthfulness to Aged Cartilage

Advanced Science, Volume 12, Issue 16, April 24, 2025.
The blockade of ZMIZ1‐GATA axis can be an effective therapeutic approach for treating OA. Functional inhibition of the ZMIZ1‐GATA axis through K‐7174 has the effect of suppressing cartilage damage and cellular senescence at the chondrocyte and cartilage tissue levels.
Jiho Nam, Hyunmin Woo, Jihye Yang, Seok Jung Kim, Kwang Pyo Lee, Ji Hoon Yu, Tae Joo Park, Seong‐il Eyun, Siyoung Yang   +8 more
wiley   +1 more source

Huanglian-Hongqu herb pair improves nonalcoholic fatty liver disease via NF-κB/NLRP3 pathway in mice: network pharmacology, molecular docking and experimental validation

Hereditas
The Huanglian-Hongqu herb pair (HH) is a carefully crafted traditional Chinese herbal compound designed to address disorders related to glucose and lipid metabolism. Its primary application lies in treating hyperlipidemia and fatty liver conditions. This
Zheng Wang, Hairong Qiu, Yang Yang, Yueyu Zhang, Taiguo Mou, Xiaobo Zhang, Yong Zhang   +6 more
doaj   +1 more source

FUS Selectively Facilitates circRNAs Packing into Small Extracellular Vesicles within Hypoxia Neuron

Advanced Science, EarlyView.
This study aimed to unravel the role of FUS in the loading of functional circRNAs into neuronal sEVs under hypoxic conditions, which involves their aggregations in SGs and specific interaction between the FUS Zf_RanBP domain to regulate circRNA sorting in sEVs.
Jiankun Zang, Yousheng Wu, Xuanlin Su, Kaiwei Cai, Man Ke, Niu He, Huili Zhu, Zefeng Tan, Jielin Zhu, Wensheng He, Min Peng, Shiqing Zhang, Hongcheng Mai, Anding Xu, Dan Lu   +14 more
wiley   +1 more source

Ribonuclease 1 Induces T‐Cell Dysfunction and Impairs CD8+ T‐Cell Cytotoxicity to Benefit Tumor Growth through Hijacking STAT1

Advanced Science, Volume 12, Issue 13, April 3, 2025.
T‐cell immunotherapy eliminates cancer growth by activating T cells, but immunosuppressive factors hinders their effectiveness, resulting in treatment failure. Here, ribonuclease 1 (RNase1) causes T‐cell dysfunction and promotes exhausted T‐cell signatures in cancers.
Wen‐Hao Yang, Bao‐Yue Huang, Hsing‐Yu Rao, Peng Ye, Bi Chen, Hao‐Ching Wang, Chih‐Hung Chung, Heng‐Hsiung Wu, Hung‐Rong Yen, Shao‐Chun Wang, Jong‐Ho Cha, Xiuwen Yan, Muh‐Hwa Yang, Mien‐Chie Hung   +13 more
wiley   +1 more source

Sini San ameliorates lipid metabolism in hyperprolactinemia rat with liver-depression

Current Research in Food Science
Sini San (SNS) is used to treat liver depression and is applied in both food and herbal medicine. Hyperprolactinemia (HPRL) is a common endocrine disorder, and patients with HPRL are usually associated with depressive symptoms.
Weidong Xu, Shasha Tian, Guanqun Mao, Yu Li, Hua Qian, Wenhua Tao   +5 more
doaj  

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source

Pharmacological Dissection Identifies Retatrutide Overcomes the Therapeutic Barrier of Obese TNBC Treatments through Suppressing the Interplay between Glycosylation and Ubiquitylation of YAP

Advanced Science, Volume 12, Issue 11, March 20, 2025.
This study reveals that obesity‐driven metabolic dysfunction enhances YAP O‐GlcNAcylation, facilitating its stabilization by preventing ubiquitylation and degradation via EIF3H, thereby driving TNBC progression and chemoresistance. Retatrutide disrupts this axis by suppressing O‐GlcNAcylation, restoring YAP ubiquitylation, and enhancing degradation ...
Xin Cui, Yueming Zhu, Lidan Zeng, Mengyuan Zhang, Amad Uddin, Theresa W. Gillespie, Lauren E. McCullough, Shaying Zhao, Mylin A. Torres, Yong Wan   +9 more
wiley   +1 more source