Results 31 to 40 of about 133,738 (306)

Antinociceptive Activity of Macaranga denticulata Muell. Arg. (Family: Euphorbiaceae): In Vivo and In Silico Studies

Medicines, 2017
Background: The present study was conducted to investigate the antinociceptive activity of methanol extract of Macaranga denticulata (Met.MD) in an animal model, followed by molecular docking analysis.
Abul Hasanat, Tanvir Ahmad Chowdhury, Mohammad Shah Hafez Kabir, Mohammed Sohel Chowdhury, Md. Nazim Uddin Chy, Jackie Barua, Nishan Chakrabarty, Arkajyoti Paul   +7 more
doaj   +1 more source

A perception-action strategy for hummingbirds [PDF]

, 2010
Many human and animal tasks are thought to be controlled with the tau informational variable. It is widely accepted that controlling the rate of change of tau during decelerative tasks, such as when braking or landing, is one common perceptual control ...
Delafield-Butt, Jonathan, Galler, Andreas, Lee, David, Schögler, Benjaman   +3 more
core   +2 more sources

Cellulose acetate phthalate, a common pharmaceutical excipient, inactivates HIV-1 and blocks the coreceptor binding site on the virus envelope glycoprotein gp120 [PDF]

, 2001
BACKGROUND: Cellulose acetate phthalate (CAP), a pharmaceutical excipient used for enteric film coating of capsules and tablets, was shown to inhibit infection by the human immunodeficiency virus type 1 (HIV-1) and several herpesviruses. CAP formulations
A Boyum, A Robert Neurath, A Trkola, A Trkola, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AR Neurath, Asim K Debnath, CD Rizzuto, CK Lapham, CM Javan, DR Burton, DR Littman, EA Berger, F Cocchi, G Alkhatib, H Choe, H Deng, J Bilello, JA Este, JC Lee, K Javaherian, KH Manson, L Wu, L Xiao, M Baba, M Baba, M Moulard, M Thali, MA Skinner, MC Peitsch, Nathan Strick, P Greenhead, PD Kwong, RA Anderson, RA Maguire, RF Speck, RJ Shattock, S Harada, S Laal, S Matsushita, S Rusconi, S Shaunak, T Dragic, T Gyotoku, T Kawamura, T Muster, TN Hart, WR Melander, Y Feng, YI Rumyantseva, Yun-Yao Li   +55 more
core   +3 more sources

Exploring anti-nonalcoholic fatty liver disease mechanism of Gardeniae Fructus by combining an animal model with network pharmacology and molecular docking [PDF]

, 2020
Abstract Background Gardeniae Fructus (GF), a traditional Chinese medicine in clinic for the treatment of nonalcoholic fatty liver disease (NAFLD). However, the mechanisms of action of GF was still margin. To explore the efficacy and mechanism of action of GF for the treatment of NAFLD, we proposed a strategy combined in vivo efficacy ...
Lin Li, Lihua Lu, Zhong-yan Tang, Zhengxiang Xia   +3 more
openaire   +1 more source

Lamb behaviour during and shortly after tail-docking

South African Journal of Animal Science
Routine husbandry procedures for lambs are increasingly scrutinised for their animal welfare implications. One such procedure is tail-docking, which is commonly performed to prevent breech blowfly strike.
M Teubes, AJ Scholtz, K Dzama, SWP Cloete   +3 more
doaj   +1 more source

Multiple functional neurosteroid binding sites on GABAA receptors [PDF]

, 2019
Neurosteroids are endogenous modulators of neuronal excitability and nervous system development and are being developed as anesthetic agents and treatments for psychiatric diseases.
Akk, Gustav, Bracamontes, John R, Budelier, Melissa M, Chen, Zi-Wei, Cheng, Wayland W. L., Covey, Douglas F, Evers, Alex S, Germann, Allison L, Kathiresan, Krishnan, Manion, Brad, Qian, Ming-Xing, Reichert, David E, Shin, Daniel J   +12 more
core   +3 more sources

Does tail docking prevent Cochliomyia hominivorax myiasis in sheep? A six-year retrospective cohort study

Animal Welfare
Tail docking is a husbandry practice widely incorporated in sheep farms around the world. It is an irreversible mutilation that impairs animal welfare, both immediately and in the longer term.
Giuliano Pereira de Barros, Maria José Hötzel, Marceli Carvalho da Silva, Laura Lívia Arias Avilés, Patrizia Ana Bricarello   +4 more
doaj   +1 more source

Circulating microRNA profiles are associated with acute pain and stress in castrated and tail docked lambs

Veterinary and Animal Science
Maintaining animal welfare is an essential component of animal production systems. However, multiple measurements are required to inform an animal's welfare state as there are currently no universal measurement tools.
Ryan J. Farr, Christopher Cowled, Carlos Rodrigues, Christina L. Rootes, Dana L.M. Campbell, Caroline Lee, Cameron R. Stewart, Danila Marini   +7 more
doaj   +1 more source

A Smo/Gli multitarget hedgehog pathway inhibitor impairs tumor growth [PDF]

, 2019
Pharmacological Hedgehog (Hh) pathway inhibition has emerged as a valuable anticancer strategy. A number of small molecules able to block the pathway at the upstream receptor Smoothened (Smo) or the downstream effector glioma-associated oncogene 1 (Gli1)
Balducci, Silvia, BASILI, IRENE, Botta, Bruno, Bufalieri, Francesca, Caimano, Miriam, Di Marcotullio, Lucia, Ghirga, Francesca, Infante, Paola, LORICCHIO, ELENA, LOSPINOSO SEVERINI, LUDOVICA, Maroder, Marella, Moretti, Marta, Mori, Mattia, Quaglio, Deborah, ROMEO, ISABELLA   +14 more
core   +1 more source

Long-Lasting Anti-Inflammatory and Antinociceptive Effects of Acute Ammonium Glycyrrhizinate Administration: Pharmacological, Biochemical, and Docking Studies

Molecules, 2019
The object of the study was to estimate the long-lasting effects induced by ammonium glycyrrhizinate (AG) after a single administration in mice using animal models of pain and inflammation together with biochemical and docking studies.
Francesco Maione, Paola Minosi, Amalia Di Giannuario, Federica Raucci, Maria Giovanna Chini, Simona De Vita, Giuseppe Bifulco, Nicola Mascolo, Stefano Pieretti   +8 more
doaj   +1 more source