Results 31 to 40 of about 2,947,274 (350)

Utilizing network pharmacology, molecular docking, and animal models to explore the therapeutic potential of the WenYang FuYuan recipe for cerebral ischemia-reperfusion injury through AGE-RAGE and NF-κB/p38MAPK signaling pathway modulation

Experimental Gerontology
Stroke is a debilitating condition with high morbidity, disability, and mortality that significantly affects the quality of life of patients. In China, the WenYang FuYuan recipe is widely used to treat ischemic stroke. However, the underlying mechanism remains unknown, so exploring the potential mechanism of action of this formula is of great practical
Ding Zhang, Hongling Qin, Wei Chen, Junjun Xiang, Minghe Jiang, Ling Zhang, Keqing Zhou, Yueqiang Hu   +7 more
openalex   +4 more sources

Long-Lasting Anti-Inflammatory and Antinociceptive Effects of Acute Ammonium Glycyrrhizinate Administration: Pharmacological, Biochemical, and Docking Studies

Molecules, 2019
The object of the study was to estimate the long-lasting effects induced by ammonium glycyrrhizinate (AG) after a single administration in mice using animal models of pain and inflammation together with biochemical and docking studies.
Francesco Maione, Paola Minosi, Amalia Di Giannuario, Federica Raucci, Maria Giovanna Chini, Simona De Vita, Giuseppe Bifulco, Nicola Mascolo, Stefano Pieretti   +8 more
doaj   +2 more sources

Integrating network pharmacology, molecular docking, and animal studies to investigate the protective effect of astragalus polysaccharide on fluoride-induced renal injury in rats

Ecotoxicology and Environmental Safety
Fluoride is an essential trace element required for normal physiological functions and holds significant importance for human health. However, excessive fluoride intake can lead to renal damage, for which effective prevention and therapeutic strategies remain scarce.
Xiaoyue Zhang, Qiang Yan, Yuanyuan Xiao, Xin Du, Xuehua Zhang, Didong Lou, Fang Peng, Daiyong Chen, Wenchao Tang   +8 more
openalex   +4 more sources

Preparatory work for the future development of animal based measures for assessing the welfare of pig ‐ Report 2: Preparatory work for the future development of animal based measures for assessing the welfare of weaned, growing and fattening pigs including aspects related to space allowance, floor types, tail biting and need for tail docking [PDF]

EFSA Supporting Publications, 2011
The EFSA Animal Health and Welfare panel is requested to develop several scientific opinions concerning animal based measures to assess the welfare of livestock animals. Before this work can start, it is important that conclusions and recommendations of the EFSA scientific opinions are ...
H.A.M. Spoolder, M.B.M. Bracke, Christine Mueller‐Graf, S.A. Edwards   +3 more
openalex   +3 more sources

Mechanism of Bazhen decoction in the treatment of colorectal cancer based on network pharmacology, molecular docking, and experimental validation

Frontiers in Immunology, 2023
Objective Bazhen Decoction (BZD) is a common adjuvant therapy drug for colorectal cancer (CRC), although its anti-tumor mechanism is unknown. This study aims to explore the core components, key targets, and potential mechanisms of BZD treatment for CRC ...
Shuai Lu, Xibo Sun, Zhongbao Zhou, Huazhen Tang, Ruixue Xiao, Qingchen Lv, Bing Wang, Jinxiu Qu, Jinxuan Yu, Fang Sun, Zhuoya Deng, Yuying Tian, Cong Li, Zhenpeng Yang, Penghui Yang, Benqiang Rao   +15 more
semanticscholar   +1 more source

Neuroprotective Effect of Methanolic Ajwa Seed Extract on Lipopolysaccharide-Induced Memory Dysfunction and Neuroinflammation: In Vivo, Molecular Docking and Dynamics Studies

Plants, 2023
Islamic literature has indicated that daily consumption of Ajwa dates heals a variety of chronic diseases and disorders. The current research investigates the neuroprotective effect of methanolic Ajwa seed extract (MASE) on lipopolysaccharide (LPS ...
V. Mani, Minhajul Arfeen, D. Dhaked, H. Mohammed, P. Amirthalingam, Hossam A Elsisi   +5 more
semanticscholar   +1 more source

Structural Insights into Neonicotinoids and N-Unsubstituted Metabolites on Human nAChRs by Molecular Docking, Dynamics Simulations, and Calcium Imaging

International Journal of Molecular Sciences, 2023
Neonicotinoid pesticides were initially designed in order to achieve species selectivity on insect nicotinic acetylcholine receptors (nAChRs). However, concerns arose when agonistic effects were also detected in human cells expressing nAChRs.
Karin Grillberger, Eike Cöllen, C. I. Trivisani, J. Blum, M. Leist, G. Ecker   +5 more
semanticscholar   +1 more source

Synthesis, antimycobacterial evaluation, and molecular docking study of 1,2,4-triazole derivatives

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Fifteen 1,2,4-triazole derivatives were synthesised in this study and their MIC values against Mycobacterium tuberculosis (Mtb) ranged from 2 to 32 μg/mL.
Meng‐Yu Xia, Yunyao Cai, Jun-Xian Chen, Xin Zhao, Hongtao Dong, Zai-Chang Yang   +5 more
semanticscholar   +1 more source

An integrative reverse vaccinology, immunoinformatic, docking and simulation approaches towards designing of multi-epitopes based vaccine against monkeypox virus

Journal of Biomolecular Structure and Dynamics, 2022
Monkeypox is a viral zoonotic disease that is caused by the monkeypox virus (MPXV) and is mainly transmitted to human through close contact with an infected person, animal, or fomites which is contaminated by the virus.
Asad Ullah, Farah Shahid, M. Haq, Muhammad Tahir ul Qamar, Muhammad Irfan, Bilal Shaker, Sajjad Ahmad, Faris A Alrumaihi, Khaled S. Allemailem, A. Almatroudi   +9 more
semanticscholar   +1 more source

Biological Effect of Quercetin in Repairing Brain Damage and Cerebral Changes in Rats: Molecular Docking and In Vivo Studies

BioMed Research International, 2022
This study examined the protective effect of quercetin against high-altitude-induced brain damage in rats. A molecular docking study was performed to investigate the potential effect of quercetin in reducing brain damages through its ability to target ...
Ahmed B. M. Mehany, A. Belal, Eman Y. Santali, S. Shaaban, Mohammad A S Abourehab, Ola A. El-Feky, Mahmoud Diab, F. M. Abou Galala, E. Elkaeed, Ghada Abdelhamid   +9 more
semanticscholar   +1 more source