Results 71 to 80 of about 3,160,114 (308)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem   +9 more
wiley   +1 more source

Biodegradable 3D‐Printable and Coatable Antifouling Composites for Marine Applications

open access: yesAdvanced Functional Materials, EarlyView.
Marine biofouling damages submerged surfaces and raises greenhouse gas emissions. Biodegradable antifouling biocomposites were developed by hot‐mixing beeswax, Tween 80, and calcium stearate or stearic acid. Adjusting the component ratio enables processing via hot‐pressing, 3D‐printing, or dip‐coating.
Gabriele Corigliano   +17 more
wiley   +1 more source

GPU Accelerated Molecular Docking Simulation with Genetic Algorithms [PDF]

open access: yes, 2016
Receptor-Ligand Molecular Docking is a very computationally expensive process used to predict possible drug candidates for many diseases. A faster docking technique would help life scientists to discover better therapeutics with less effort and time. The requirement of long execution times may mean using a less accurate evaluation of drug candidates ...
Altuntaş, Serkan   +3 more
openaire   +3 more sources

Hardware-in-the-loop Rendezvous Simulation using a Vision Based Sensor [PDF]

open access: yes, 2011
One of the critical issues of a satellite On-Orbit Servicing (OOS) mission is to ensure a safe and reliable Rendezvous and Docking (RvD) process. This most risky part of the mission must be carefully analyzed, simulated and verified before the mission ...
Boge , Toralf   +2 more
core  

NeuroVisio SyncPatch: A Skin‐Conformal Multimodal EMG–Motion Sensing Platform for Quantitative Neuromuscular Rehabilitation and Performance Monitoring

open access: yesAdvanced Healthcare Materials, EarlyView.
NeuroVisio SyncPatch integrates skin‐conformal electromyography (EMG) electrodes with camera‐tracked markers to jointly assess muscle activity and three‐dimensional knee kinematics during rehabilitation. Parallel feedback pathways provide real‐time kinematic guidance during movement and post‐trial neuromuscular feedback.
Bohyung Choi   +11 more
wiley   +1 more source

EPOS – Using Robotics for RvD Simulation of On-Orbit Servicing Missions [PDF]

open access: yes, 2010
Increasing complexity and costs of satellite missions promote the idea of extending the operational lifetime or improving functionalities/performance of a satellite in orbit instead of simply replacing it by a new one.
Ou Ma   +7 more
core   +1 more source

Biomass DNA: An Emerging Building Block for Advanced Materials

open access: yesAdvanced Materials, EarlyView.
Biomass DNA is rapidly emerging from its traditional role as a genetic blueprint to serve as a versatile abundant, highly programmable polymeric building block. This review highlights the transformation of macroscopic bulk biomass DNA into next generation of functional materials, spanning from dynamic hydrogels, sustainable bioplastics, and high ...
Yuwei Hu, Itamar Willner, Li Niu
wiley   +1 more source

Budget Message of Governor George Docking to the Legislature of Kansas, 1958

open access: yes, 1958
application/pdf January 14, 1958. Includes Message of Governor George Docking to the Special Session of the Kansas Legislature, April 21 ...
Kansas. Governor (1957-1961 : Docking)
core   +1 more source

Marine Longilenes, Oxasqualenoids with Ser-Thr Protein Phosphatase 2A Inhibition Activity

open access: yesMarine Drugs, 2018
The red seaweed Laurencia viridis is a rich source of oxygenated secondary metabolites that were derived from squalene. We report here the structures of three novel compounds, (+)-longilene peroxide (1), longilene (2), and (+)-prelongilene (3) that were ...
Francisco Cen-Pacheco   +5 more
doaj   +1 more source

Results of direct docking simulation experiments.

open access: yes, 2018
Results of direct docking simulation experiments.
Antonio Varriale (297193)   +4 more
core   +1 more source

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