Results 91 to 100 of about 1,745,904 (301)
Molecular Oncology, EarlyView.Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece +18 more
wiley +1 more source
Can biochar ameliorate phosphorus deficiency and aluminium phytotoxicity in acid soils? : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy of Applied Science in Soil Science at Massey University, Palmerston North, New Zealand [PDF]
, 2015 The use of biochar as soil amendment to enhance soil functionality is being increasingly investigated, with particular attention given to its effects on the sustainable increase of crop production and carbon (C) sequestration. To date, however, limited
Shen, Qinhua
core
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Степан Зенонович Гжицький – визначний науковець і педагог [PDF]
, 2013 Стаття присвячена науковій і педагогічній діяльності визначного українського вченого-біолога, доктора біологічних наук, академіка Української академії аграрних наук, заслуженого діяча науки і техніки України С. З.
Панюс, М. В.
core
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
SHEVCHENKIANA DOCTOR 2018 – SYMBIOSIS OF SCIENCE AND CULTURE: FROM SHEVCHENKO TO THE PRESENT
Праці Наукового товариства імені Шевченка. Медичні науки, 2018 SHEVCHENKIANA DOCTOR 2018 – SYMBIOSIS OF SCIENCE AND CULTURE: FROM SHEVCHENKO TO THE ...
Olena Adamovych
doaj
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source