Results 41 to 50 of about 31,499 (264)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Transformations of the human communities in the eastern part of the Carpathian Basin between the middle of the 5th and 7th century

Dissertationes Archaeologicae: Ex Instituto Archaeologico Universitatis de Rolando Eötvös Nominatae, 2019
of PhD thesis submitted in 2018 to the Archaeology Doctoral Programme, Doctoral School of History, Eötvös Loránd University, Budapest under the supervision of Tivadar Vida.
Alpár Dobos
doaj   +1 more source

Assessing and Strengthening African Universities' Capacity for Doctoral Programmes [PDF]

PLoS Medicine, 2011
Imelda Bates y sus colegas desarrollaron y validaron una herramienta basada en la evidencia para evaluar programas de doctorado en universidades africanas.
Imelda Bates, Richard Odame Phillips, Ruby Martin-Peprah, Gibson Kibiki, Oumar Gaye, Kamija S. Phiri, Harry Tagbor, Sue Purnell   +7 more
openaire   +5 more sources

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Complex, household-based analysis of the stone tools of Polgár-Csőszhalom

Dissertationes Archaeologicae: Ex Instituto Archaeologico Universitatis de Rolando Eötvös Nominatae, 2020
of PhD thesis submitted in 2019 to the Archaeology Doctoral Programme, Doctoral School of History, Eötvös Loránd University, Budapest under the supervision of Pál Raczky and Zsolt Mester.
Norbert Faragó
doaj   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Late groups of the Alföld Linear Pottery culture in north-eastern Hungary. New results of the research in Borsod-Abaúj-Zemplén County

Dissertationes Archaeologicae: Ex Instituto Archaeologico Universitatis de Rolando Eötvös Nominatae, 2015
of PhD thesis submitted in 2014 to the Archaeology Doctoral Programme, Doctoral School of History, Eötvös Loránd University, Budapest under the supervision of Pál Raczky.
Piroska Csengeri
doaj   +1 more source

‘...circa Danubium...’ from the Late Avar Age until the Early Árpádian Age: 8th–11th-Century Settlements in the Region of the Central Part of the Hungarian Little Plain and the Danube Bend

Dissertationes Archaeologicae: Ex Instituto Archaeologico Universitatis de Rolando Eötvös Nominatae, 2020
and further consideration of the PhD thesis submitted in the winter of 2018 to the Archaeology Doctoral Programme, Doctoral School of History, Eötvös Loránd University, Budapest under the supervision of Miklós Takács.
Szabina Merva
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source