Results 51 to 60 of about 2,443,850 (303)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

LETTRE D’INFORMATION SUR LE PORTFOLIO DE THÈSE

, 2021
Paris, le 17 février 2021 Lors de la dernière réunion du Collège doctoral (instance qui regroupe la direction de l’Institut de formation doctoral et les directeurs·trices des ED) du 20 janvier dernier, un document intitulé « Déployer l’approche ...
Collectif Doctoral
core  

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Transformations of the human communities in the eastern part of the Carpathian Basin between the middle of the 5th and 7th century

Dissertationes Archaeologicae: Ex Instituto Archaeologico Universitatis de Rolando Eötvös Nominatae, 2019
of PhD thesis submitted in 2018 to the Archaeology Doctoral Programme, Doctoral School of History, Eötvös Loránd University, Budapest under the supervision of Tivadar Vida.
Alpár Dobos
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Responsive public health doctoral education: experiences and reflections from a School of Public Health in South Africa

BMJ Global Health
Institutional capacity for doctoral training is key to addressing the complex challenges facing the global south. In the context of the need for skilled knowledge workers in health systems and growing demand for doctoral places, we reflect on the ...
Helen Schneider, Brian van Wyk, Uta Lehmann, Woldekidan Amde, Corinne Carolissen   +4 more
doaj   +1 more source

Complex, household-based analysis of the stone tools of Polgár-Csőszhalom

Dissertationes Archaeologicae: Ex Instituto Archaeologico Universitatis de Rolando Eötvös Nominatae, 2020
of PhD thesis submitted in 2019 to the Archaeology Doctoral Programme, Doctoral School of History, Eötvös Loránd University, Budapest under the supervision of Pál Raczky and Zsolt Mester.
Norbert Faragó
doaj   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Late groups of the Alföld Linear Pottery culture in north-eastern Hungary. New results of the research in Borsod-Abaúj-Zemplén County

Dissertationes Archaeologicae: Ex Instituto Archaeologico Universitatis de Rolando Eötvös Nominatae, 2015
of PhD thesis submitted in 2014 to the Archaeology Doctoral Programme, Doctoral School of History, Eötvös Loránd University, Budapest under the supervision of Pál Raczky.
Piroska Csengeri
doaj   +1 more source

Programme doctoral « Études méditerranéennes » 2022-2023

Sociétés en mutation en Méditerranée, 2023
L’Institut Sociétés en Mutation en Méditerranée (SoMuM) propose une offre de formation accessible aux doctorants appartenant aux écoles doctorales « Espaces, Cultures, Sociétés » (ED 355), « Sciences juridiques et politiques » (ED 67), « Langues, Lettres et Art (ED 354) d’Aix-Marseille Université, et rattachées aux douze laboratoires du périmètre de l ...
openaire   +2 more sources