Results 11 to 20 of about 2,420 (113)

A Mediterranean Diet-Based Food Mix Ameliorates Diabetes- and Obesity-Associated Liver Alterations Through Mitochondrial and Metabolic Reprogramming. [PDF]

Mol Nutr Food Res
Metabolic syndrome (MetS)-related diseases, such as type 2 diabetes (T2D) and obesity, are among the leading causes of liver damage, and their prevalence poses an increasing clinical challenge.
Mercurio G, Giacco A, Troise AD, Ledbetter M, De Pascale S, Scopigno N, Vigliotti M, Mazzola M, Riccio G, Scaloni A, Moreno M, Fiore A, Cioffi F, Silvestri E.   +13 more
europepmc   +4 more sources

Activation of AHR by ITE improves cardiac remodelling and function in rats after myocardial infarction. [PDF]

ESC Heart Fail, 2023
Abstract Aims Left ventricular remodelling subsequent to myocardial infarction (MI) constitutes a pivotal underlying cause of heart failure. Intervention with the nontoxic endogenous aryl hydrocarbon receptor (AHR) agonist 2‐(1′H‐indole‐3′‐carbonyl)‐thiazole‐4‐carboxylic acid methyl ester (ITE) in the acute phase of MI has been shown to ameliorate ...
Lin X, Liu W, Chu Y, Zhang H, Zeng L, Lin Y, Kang K, Peng F, Lin J, Huang C, Chai D.   +10 more
europepmc   +2 more sources

A Nonketotic Hyperglycinemia Mouse Shows Wide-Ranging Biochemical Consequences of Elevated Glycine, Reduced Folate One-Carbon Charging, and Serine Deficiency. [PDF]

J Inherit Metab Dis
ABSTRACT Nonketotic hyperglycinemia is a severe neonatal epileptic encephalopathy caused by deficient glycine cleavage enzyme activity, for which currently no effective treatment exists. Incomplete understanding of brain biochemistry represents a major knowledge gap to develop new treatments.
Swanson MA, Jiang H, Kolora LD, Molino R, Reisdorph R, Michel CR, Doenges KA, Leung KY, Lin X, Wong F, Lancaster S, Michael B, Snyder M, Hock DH, Stroud DA, Wood T, Binard R, Anderson-Lehman L, Christians U, Arning E, Friederich MW, Van Hove RA, MacLean KN, Greene NDE, Van Hove JLK.   +24 more
europepmc   +2 more sources

Updated safety evaluation of the food enzyme phospholipase A₂ from the genetically modified <i>Trichoderma reesei</i> strain RF8793. [PDF]

EFSA J
Abstract The food enzyme phospholipase A2 (phosphatidylcholine 2‐acylhydrolase; EC 3.1.1.4) is produced with the genetically modified Trichoderma reesei strain RF8793 by AB Enzymes GmbH. In a previous opinion, the total organic solids (TOS) values could not be calculated, which led to the inability to establish the representativeness of the batch used ...
EFSA Panel on Food Enzymes (FEZ), Zorn H, Barat Baviera JM, Bolognesi C, Catania F, Gadermaier G, Greiner R, Mayo B, Mortensen A, Roos YH, Solano M, Van Loveren H, Vernis L, Criado A, Liu Y.   +14 more
europepmc   +2 more sources

Cyclocreatine treatment ameliorates the cognitive, autistic and epileptic phenotype in a mouse model of Creatine Transporter Deficiency [PDF]

, 2020
Creatine Transporter Deficiency (CTD) is an inborn error of metabolism presenting with intellectual disability, behavioral disturbances and epilepsy. There is currently no cure for this disorder.
Alessandrì, Maria Grazia, Baroncelli, Laura, Battini, Roberta, Butt, Mark, Cacciante, Francesco, Cerri, Elisa, Cioni, Giovanni, Do, Minh-Ha T, Gennaro, Mariangela, Lupori, Leonardo, Mazziotti, Raffaele, McKew, John C, Pizzorusso, Tommaso, Putignano, Elena, Sagona, Giulia   +14 more
core   +7 more sources

Echinococcus granulosus antigen B regulates T-cell function through inhibition of signal transducer and activator of transcription 3 in experimental immune thrombocytopenia. [PDF]

Br J Haematol
During the pathological process of immune thrombocytopenia, signal transducer and activator of transcription 3 (STAT3) is activated by JAKs, leading to the production of a large number of inflammatory cytokines and promoting the activation of Th1, Th2 and Th17 cells.
Yue Y, Zhang Y, Cheng Y, Jiao H, Yan M.
europepmc   +2 more sources

The role of preclinical models in creatine transporter deficiency: Neurobiological mechanisms, biomarkers and therapeutic development [PDF]

, 2021
Creatine (Cr) Transporter Deficiency (CTD) is an X-linked metabolic disorder, mostly caused by missense mutations in the SLC6A8 gene and presenting with intellectual disability, autistic behavior, and epilepsy. There is no effective treatment for CTD and
Baroncelli L., Battini R., Calugi F., Cioni G., Di Vetta F., Ghirardini E., Palma M., Pizzorusso T., Sagona G.   +8 more
core   +2 more sources

Ferritin heavy chain Is the host factor responsible for HCV-Induced inhibition of apoB-100 production and is required for efficient viral infection [PDF]

, 2012
Hepatic fat export occurs by apolipoprotein B-100-containing lipoprotein production, whereas impaired production leads to liver steatosis. Hepatitis C virus (HCV) infection is associated to dysregulation of apoB-100 secretion and steatosis; however, the ...
AMICONE, Laura, Claudia Montaldo, Cristina Di Giacomo, Giuseppe Ippolito, Laura Santangelo, Leopoldo Paolo Pucillo, MANCONE, Carmine, Tonino Alonzi, TRIPODI, Marco, Viviana Costa   +9 more
core   +3 more sources

Antioxidant effects of ethyl acetate extract of Desmodium gangeticum root on myocardial ischemia reperfusion injury in rat hearts [PDF]

, 2010
Background This study aims to evaluate the antioxidant potential of the ethyl acetate extract of Desmodium gangeticum root for cardioprotection from ischemia reperfusion-induced oxidative stress.
Gino A Kurian, Srilalitha Suryanarayanan, Archana Raman, Jose Padikkala   +3 more
core   +2 more sources

Updated ACVIM consensus statement on leptospirosis in dogs

Journal of Veterinary Internal Medicine, Volume 37, Issue 6, Page 1966-1982, November/December 2023., 2023
Abstract Since publication of the last consensus statement on leptospirosis in dogs, there has been revision of leptospiral taxonomy and advancements in typing methods, widespread use of new diagnostic tests and vaccines, and improved understanding of the epidemiology and pathophysiology of the disease.
Jane E. Sykes, Thierry Francey, Simone Schuller, Robyn A. Stoddard, Larry D Cowgill, George E. Moore   +5 more
wiley   +1 more source