Results 1 to 10 of about 13,341 (153)

Lack of Genetic Differentiation of Five Triatomine Species Belonging to the Triatoma rubrovaria Subcomplex (Hemiptera, Reduviidae) [PDF]

Insects
The Triatoma rubrovaria subcomplex, comprising several triatomine species, plays a significant role in the transmission of Chagas disease in southern Brazil.
Amanda R. Caetano, Lucas B. Mosmann, Thaiane Verly, Stephanie Costa, Jader Oliveira, Constança Britto, Márcio G. Pavan   +6 more
doaj   +2 more sources

Tumor Necrosis Factor Is a Therapeutic Target for Immunological Unbalance and Cardiac Abnormalities in Chronic Experimental Chagas’ Heart Disease

Mediators of Inflammation, 2014
Background. Chagas disease (CD) is characterized by parasite persistence and immunological unbalance favoring systemic inflammatory profile. Chronic chagasic cardiomyopathy, the main manifestation of CD, occurs in a TNF-enriched milieu and frequently ...
Isabela Resende Pereira, Glaucia Vilar-Pereira, Andrea Alice Silva, Otacilio Cruz Moreira, Constança Britto, Ellen Diana Marinho Sarmento, Joseli Lannes-Vieira   +6 more
doaj   +2 more sources

Ecological Perspectives on Leishmaniasis Parasitism Patterns: Evidence of Possible Alternative Vectors for Leishmania (Leishmania) infantum (syn. L. chagasi) and Leishmania (Viannia) braziliensis in Piauí, Brazil [PDF]

Pathogens
Leishmaniasis is difficult to control due to clinical and vector diversity associated with the complex life cycle of Leishmania parasites, which are transmitted by sandflies.
Raimundo Leoberto Torres de Sousa, Thais Araujo-Pereira, Silvia Alcântara Vasconcelos, Simone Mousinho Freire, Oriana Bezerra Lima, Jacenir Reis dos Santos-Mallet, Mauricío Luiz Vilela, Victor Manoel de Sousa Vasconcelos, Etielle Barroso de Andrade, Régis Gomes, Clarissa Teixeira, Bruno Moreira Carvalho, Daniela Pita-Pereira, Constança Britto   +13 more
doaj   +2 more sources

Efficacy of the treatment using a microemulsion loaded with epoxy-α-lapachone in combination with meglumine antimoniate against murine infection by Leishmania (Leishmania) amazonensis [PDF]

International Journal for Parasitology: Drugs and Drug Resistance
Leishmaniasis is a disease caused by Leishmania spp., affecting millions of people around the world. For decades, its treatment has been based on pentavalent antimonials, which notoriously cause toxic side effects in patients.
Juliana Figueiredo Peixoto, Luiz Filipe Gonçalves-Oliveira, Franklin Souza-Silva, Luzia Monteiro de Castro Côrtes, Léa Cysne Finkelstein, Geovane Dias-Lopes, Beatriz Ferreira de Carvalho Patricio, Carolina Guimarães de Souza Lima, Helvécio Vinícius Antunes Rocha, Fernando de Carvalho da Silva, Vitor Francisco Ferreira, Bernardo Acácio Santini Pereira, Carlos Roberto Alves   +12 more
doaj   +2 more sources

Suppression of TGF‐β/Smad2 signaling by GW788388 enhances DENV‐2 clearance in macrophages

Journal of Medical Virology, Volume 94, Issue 9, Page 4359-4368, September 2022., 2022
Abstract Dengue fever, caused by the dengue virus (DENV‐1, −2, −3, and −4), affects millions of people in the tropical and subtropical regions worldwide. Severe dengue is correlated with high viraemia and cytokine storm, such as high levels of transforming growth factor‐β1 (TGF‐β1) in the patient's serum.
Gabrielly Sbano Teixeira, Audrien Alves Andrade, Lauana Ribas Torres, Dinair Couto‐Lima, Otacilio C. Moreira, Rayane Abreu, Mariana Caldas Waghabi, Elen Mello de Souza   +7 more
wiley   +1 more source

Epoxy-α-lapachone (2,2-Dimethyl-3,4-dihydro-spiro[2H-naphtho[2,3-b]pyran-10,2′-oxirane]-5(10H)-one): a promising molecule to control infections caused by protozoan parasites

Brazilian Journal of Infectious Diseases, 2023
Natural products and their derivatives have been sources of search and research for new drugs for the treatment of neglected diseases. Naphthoquinones, a special group of quinones, are products of natural metabolites with a wide spectrum of biological ...
Juliana Figueiredo Peixoto, Adriane da Silva Oliveira, Luiz Filipe Gonçalves - Oliveira, Franklin Souza - Silva, Carlos Roberto Alves   +4 more
doaj   +1 more source

Combining Well‐Tempered Metadynamics Simulation and SPR Assays to Characterize the Binding Mechanism of the Universal T‐Lymphocyte Tetanus Toxin Epitope TT830‐843

BioMed Research International, Volume 2021, Issue 1, 2021., 2021
Peptide TT830‐843 from the tetanus toxin is a universal T‐cell epitope. It helps in vaccination and induces T‐cell activation. However, the fine molecular interaction between this antigen and the major histocompatibility complex (MHC) remains unknown.
Artur A. M. L. Brandt, Rodrigo N. Rodrigues-da-Silva, Josué C. Lima-Junior, Carlos R. Alves, Franklin de Souza-Silva, Sebastien Fiorucci   +5 more
wiley   +1 more source

In Silico Insights into the Mechanism of Action of Epoxy-α-Lapachone and Epoxymethyl-Lawsone in Leishmania spp.

Molecules, 2021
Epoxy-α-lapachone (Lap) and Epoxymethyl-lawsone (Law) are oxiranes derived from Lapachol and have been shown to be promising drugs for Leishmaniases treatment.
Juliana Figueiredo Peixoto, Adriane da Silva Oliveira, Patrícia Queiroz Monteiro, Luiz Filipe Gonçalves-Oliveira, Valter Viana Andrade-Neto, Vitor Francisco Ferreira, Franklin Souza-Silva, Carlos Roberto Alves   +7 more
doaj   +1 more source

Degron Pathways and Leishmaniasis: Debating Potential Roles of Leishmania spp. Proteases Activity on Guiding Hosts Immune Response and Their Relevance to the Development of Vaccines

Vaccines, 2023
Degrons are short peptide sequences that signalize target sites for protein degradation by proteases. Herein, we bring forth the discussion on degrons present in proteins related to the immune system of Mus musculus that are potential targets for ...
Adriane Silva Oliveira, Lara Mata Aredes-Riguetti, Bernardo Acácio Santini Pereira, Carlos Roberto Alves, Franklin Souza-Silva   +4 more
doaj   +1 more source

Recent advances in surface plasmon resonance as a powerful approach for studying Leishmania spp. and Trypanosoma cruzi parasites

Talanta Open, 2023
Leishmaniases and Chagas disease pose significant health challenges, particularly in tropical regions among impoverished communities. These conditions prevail in areas characterized by limited resources and have necessitated the continuous development of
Fatemeh Farshchi, Geovane Dias-Lopes, Luzia Monteiro Castro-Côrtes, Carlos Roberto Alves, Franklin Souza-Silva   +4 more
doaj   +1 more source