Results 21 to 30 of about 193,255 (148)

In Silico Insights into the Mechanism of Action of Epoxy-α-Lapachone and Epoxymethyl-Lawsone in Leishmania spp.

Molecules, 2021
Epoxy-α-lapachone (Lap) and Epoxymethyl-lawsone (Law) are oxiranes derived from Lapachol and have been shown to be promising drugs for Leishmaniases treatment.
Juliana Figueiredo Peixoto, Adriane da Silva Oliveira, Patrícia Queiroz Monteiro, Luiz Filipe Gonçalves-Oliveira, Valter Viana Andrade-Neto, Vitor Francisco Ferreira, Franklin Souza-Silva, Carlos Roberto Alves   +7 more
doaj   +1 more source

Doenças endêmicas: abordagens sociais, culturais e comportamentais [PDF]

, 2000
No mundo, cerca de meio bilhão de pessoas sofrem de enfermidades parasitárias endêmicas. Na América Latina, ainda se convive com velhas endemias como esquistossomose, malária, leshmanioses e hanseníase. A solução? Construir, de maneira solidária, o campo
Briceño-León, Roberto, Barata, Rita Barradas (org.)   +1 more
core   +2 more sources

Degron Pathways and Leishmaniasis: Debating Potential Roles of Leishmania spp. Proteases Activity on Guiding Hosts Immune Response and Their Relevance to the Development of Vaccines

Vaccines, 2023
Degrons are short peptide sequences that signalize target sites for protein degradation by proteases. Herein, we bring forth the discussion on degrons present in proteins related to the immune system of Mus musculus that are potential targets for ...
Adriane Silva Oliveira, Lara Mata Aredes-Riguetti, Bernardo Acácio Santini Pereira, Carlos Roberto Alves, Franklin Souza-Silva   +4 more
doaj   +1 more source

Recent advances in surface plasmon resonance as a powerful approach for studying Leishmania spp. and Trypanosoma cruzi parasites

Talanta Open, 2023
Leishmaniases and Chagas disease pose significant health challenges, particularly in tropical regions among impoverished communities. These conditions prevail in areas characterized by limited resources and have necessitated the continuous development of
Fatemeh Farshchi, Geovane Dias-Lopes, Luzia Monteiro Castro-Côrtes, Carlos Roberto Alves, Franklin Souza-Silva   +4 more
doaj   +1 more source

ANÁLISE ESPACIAL APLICADA NA DETERMINAÇÃO DE ÁREAS DE RISCO PARA ALGUMAS DOENÇAS ENDÊMICAS (CALAZAR, DENGUE, DIARRÉIA, D.S.T. – DOENÇAS SEXUALMENTE TRANSMISSÍVEIS E TUBERCULOSE), NO BAIRRO DE CAMPO LIMPO – FEIRA DE SANTANA (BA) [PDF]

, 2022
O presente estudo objetiva estimar áreas de risco para ocorrência de algumas doenças endêmicas no Bairro Campo Limpo, situado na periferia de Feira de Santana (BA), usando técnicas de Geoprocessamento e análise espacial.
Leal Santos, Rosângela, Oliveira Carneiro, Elisângela   +1 more
core   +1 more source

HISTOPLASMOSE CUTÂNEA EXTENSA ASSOCIADA À PÊNFIGO VULGAR EM PACIENTE IMUNOCOMPETENTE

Brazilian Journal of Infectious Diseases, 2023
A histoplasmose, causada pelo fungo Histoplasma capsulatum, é uma micose endêmica que eventualmente pode resultar em doença grave. A maioria dos pacientes que desenvolve histoplasmose severa é imunodeprimida ou está em extremos de idade.
Roberta Lestch da Silveira, Jerusa Marquardt Corazza, Fernanda Caldeira Veloso dos Santos, Thami Ellen Busanello Spanevello, Adriane Schio Pagliarini   +4 more
doaj   +1 more source

Detection of Metalloproteases and Cysteine Proteases RNA Transcripts of Leishmania (Leishmania) infantum in Ear Edge Skin of Naturally Infected Dogs

BioMed Research International, Volume 2020, Issue 1, 2020., 2020
Leishmania spp. proteases have been proposed as virulence factors contributing to adaptive success these parasites to the mammalian hosts. Since these enzymes are poorly studied in naturally infected dogs, this work aims to show the differences in metalloprotease and cysteine proteases gene expression in ear edge skin of dogs naturally infected by ...
Laura Barral Veloso, Flávia de Oliveira Cardoso, Karen dos Santos Charret, Matheus Pereira de Sá Silva, Luzia Monteiro de Castro Côrtes, Kátia da Silva Calabrese, Franklin Souza da Silva, Joel Fontes de Sousa, Marília Fonseca Rocha, Carlos Roberto Alves, Mansour El-Matbouli   +10 more
wiley   +1 more source

Serine proteases profiles of Leishmania (Viannia) braziliensis clinical isolates with distinct susceptibilities to antimony

Scientific Reports, 2021
Glucantime (SbV) is the first-line treatment against American Tegumentary Leishmaniasis. Resistance cases to this drug have been reported and related to host characteristics and parasite phenotypes.
Anabel Zabala-Peñafiel, Geovane Dias-Lopes, Léa Cysne-Finkelstein, Fátima Conceição-Silva, Luciana de Freitas Campos Miranda, Aline Fagundes, Armando de Oliveira Schubach, Maria Inês Fernandes Pimentel, Franklin Souza-Silva, Lucas de Almeida Machado, Carlos Roberto Alves   +10 more
doaj   +1 more source

Reactivity of sera from dogs living in a leishmaniasis-endemic area to the COOH-terminal region of cysteine proteinase B

Brazilian Journal of Infectious Diseases, 2020
Cysteine proteinases are well-known virulence factors of Leishmania spp. with demonstrated actions in both experimental mouse infection and human infection. However, studies on these enzymes in canine leishmaniasis are scarce.
Laura Barral-Veloso, Barbara Cristina de Albuquerque Melo, Raquel Santos-de-Souza, Léa Cysne-Finkelstein, Franklin Souza-Silva, Fernanda Nunes Santos, Joel Fontes de Sousa, Carlos Roberto Alves   +7 more
doaj   +1 more source

Overview of the organization of protease genes in the genome of Leishmania spp

Parasites & Vectors, 2014
Background The genus Leishmania includes protozoan parasites that are able to infect an array of phlebotomine and vertebrate species. Proteases are related to the capacity of these parasites to infect and survive in their hosts and are therefore ...
Mariana Silva-Almeida, Franklin Souza-Silva, Bernardo Acácio Santini Pereira, Michelle Lopes Ribeiro-Guimarães, Carlos Roberto Alves   +4 more
doaj   +1 more source