Results 1 to 10 of about 248 (58)

Tumor Necrosis Factor Is a Therapeutic Target for Immunological Unbalance and Cardiac Abnormalities in Chronic Experimental Chagas’ Heart Disease

Mediators of Inflammation, 2014
Background. Chagas disease (CD) is characterized by parasite persistence and immunological unbalance favoring systemic inflammatory profile. Chronic chagasic cardiomyopathy, the main manifestation of CD, occurs in a TNF-enriched milieu and frequently ...
Isabela Resende Pereira, Glaucia Vilar-Pereira, Andrea Alice Silva, Otacilio Cruz Moreira, Constança Britto, Ellen Diana Marinho Sarmento, Joseli Lannes-Vieira   +6 more
doaj   +2 more sources

Suppression of TGF‐β/Smad2 signaling by GW788388 enhances DENV‐2 clearance in macrophages

Journal of Medical Virology, Volume 94, Issue 9, Page 4359-4368, September 2022., 2022
Abstract Dengue fever, caused by the dengue virus (DENV‐1, −2, −3, and −4), affects millions of people in the tropical and subtropical regions worldwide. Severe dengue is correlated with high viraemia and cytokine storm, such as high levels of transforming growth factor‐β1 (TGF‐β1) in the patient's serum.
Gabrielly Sbano Teixeira, Audrien Alves Andrade, Lauana Ribas Torres, Dinair Couto‐Lima, Otacilio C. Moreira, Rayane Abreu, Mariana Caldas Waghabi, Elen Mello de Souza   +7 more
wiley   +1 more source

Epoxy-α-lapachone (2,2-Dimethyl-3,4-dihydro-spiro[2H-naphtho[2,3-b]pyran-10,2′-oxirane]-5(10H)-one): a promising molecule to control infections caused by protozoan parasites

Brazilian Journal of Infectious Diseases, 2023
Natural products and their derivatives have been sources of search and research for new drugs for the treatment of neglected diseases. Naphthoquinones, a special group of quinones, are products of natural metabolites with a wide spectrum of biological ...
Juliana Figueiredo Peixoto, Adriane da Silva Oliveira, Luiz Filipe Gonçalves - Oliveira, Franklin Souza - Silva, Carlos Roberto Alves   +4 more
doaj   +1 more source

Combining Well‐Tempered Metadynamics Simulation and SPR Assays to Characterize the Binding Mechanism of the Universal T‐Lymphocyte Tetanus Toxin Epitope TT830‐843

BioMed Research International, Volume 2021, Issue 1, 2021., 2021
Peptide TT830‐843 from the tetanus toxin is a universal T‐cell epitope. It helps in vaccination and induces T‐cell activation. However, the fine molecular interaction between this antigen and the major histocompatibility complex (MHC) remains unknown.
Artur A. M. L. Brandt, Rodrigo N. Rodrigues-da-Silva, Josué C. Lima-Junior, Carlos R. Alves, Franklin de Souza-Silva, Sebastien Fiorucci   +5 more
wiley   +1 more source

In Silico Insights into the Mechanism of Action of Epoxy-α-Lapachone and Epoxymethyl-Lawsone in Leishmania spp.

Molecules, 2021
Epoxy-α-lapachone (Lap) and Epoxymethyl-lawsone (Law) are oxiranes derived from Lapachol and have been shown to be promising drugs for Leishmaniases treatment.
Juliana Figueiredo Peixoto, Adriane da Silva Oliveira, Patrícia Queiroz Monteiro, Luiz Filipe Gonçalves-Oliveira, Valter Viana Andrade-Neto, Vitor Francisco Ferreira, Franklin Souza-Silva, Carlos Roberto Alves   +7 more
doaj   +1 more source

Degron Pathways and Leishmaniasis: Debating Potential Roles of Leishmania spp. Proteases Activity on Guiding Hosts Immune Response and Their Relevance to the Development of Vaccines

Vaccines, 2023
Degrons are short peptide sequences that signalize target sites for protein degradation by proteases. Herein, we bring forth the discussion on degrons present in proteins related to the immune system of Mus musculus that are potential targets for ...
Adriane Silva Oliveira, Lara Mata Aredes-Riguetti, Bernardo Acácio Santini Pereira, Carlos Roberto Alves, Franklin Souza-Silva   +4 more
doaj   +1 more source

Recent advances in surface plasmon resonance as a powerful approach for studying Leishmania spp. and Trypanosoma cruzi parasites

Talanta Open, 2023
Leishmaniases and Chagas disease pose significant health challenges, particularly in tropical regions among impoverished communities. These conditions prevail in areas characterized by limited resources and have necessitated the continuous development of
Fatemeh Farshchi, Geovane Dias-Lopes, Luzia Monteiro Castro-Côrtes, Carlos Roberto Alves, Franklin Souza-Silva   +4 more
doaj   +1 more source

HISTOPLASMOSE CUTÂNEA EXTENSA ASSOCIADA À PÊNFIGO VULGAR EM PACIENTE IMUNOCOMPETENTE

Brazilian Journal of Infectious Diseases, 2023
A histoplasmose, causada pelo fungo Histoplasma capsulatum, é uma micose endêmica que eventualmente pode resultar em doença grave. A maioria dos pacientes que desenvolve histoplasmose severa é imunodeprimida ou está em extremos de idade.
Roberta Lestch da Silveira, Jerusa Marquardt Corazza, Fernanda Caldeira Veloso dos Santos, Thami Ellen Busanello Spanevello, Adriane Schio Pagliarini   +4 more
doaj   +1 more source

Detection of Metalloproteases and Cysteine Proteases RNA Transcripts of Leishmania (Leishmania) infantum in Ear Edge Skin of Naturally Infected Dogs

BioMed Research International, Volume 2020, Issue 1, 2020., 2020
Leishmania spp. proteases have been proposed as virulence factors contributing to adaptive success these parasites to the mammalian hosts. Since these enzymes are poorly studied in naturally infected dogs, this work aims to show the differences in metalloprotease and cysteine proteases gene expression in ear edge skin of dogs naturally infected by ...
Laura Barral Veloso, Flávia de Oliveira Cardoso, Karen dos Santos Charret, Matheus Pereira de Sá Silva, Luzia Monteiro de Castro Côrtes, Kátia da Silva Calabrese, Franklin Souza da Silva, Joel Fontes de Sousa, Marília Fonseca Rocha, Carlos Roberto Alves, Mansour El-Matbouli   +10 more
wiley   +1 more source

Serine proteases profiles of Leishmania (Viannia) braziliensis clinical isolates with distinct susceptibilities to antimony

Scientific Reports, 2021
Glucantime (SbV) is the first-line treatment against American Tegumentary Leishmaniasis. Resistance cases to this drug have been reported and related to host characteristics and parasite phenotypes.
Anabel Zabala-Peñafiel, Geovane Dias-Lopes, Léa Cysne-Finkelstein, Fátima Conceição-Silva, Luciana de Freitas Campos Miranda, Aline Fagundes, Armando de Oliveira Schubach, Maria Inês Fernandes Pimentel, Franklin Souza-Silva, Lucas de Almeida Machado, Carlos Roberto Alves   +10 more
doaj   +1 more source